Pancreatic beta cell function 2024 GWAS: European ancestry

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Publication

Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology.
Madsen AL, Bonàs-Guarch S, et al.
Nat Metab. 2024 Oct 17. doi: 10.1038/s42255-024-01140-6.
PMID:  39420167

Phenotypes

• BIGTT acute insulin response
• Corrected insulin response (CIR)
• Disposition index calculated by BIGTT-AIR and BIGTT-S
• Disposition index calculated by modified insulinogenic and Matsuda insulin sensitivity indexes
• HOMA-B
• Insulinogenic index
• Modified insulinogenic index
• Stumvoll first-phase secretion

Experiment summary

This study analyzed genetic associations for pancreatic beta cell function phenotypes in up to 26,356 subjects of European ancestry.