GoT2D (Genetics of Type 2 Diabetes) Consortium

GoT2D logo

The GoT2D consortium aims to understand the allelic architecture of type 2 diabetes through whole-genome sequencing, high-density SNP genotyping, and imputation. The reference panel based on this work is intended as a comprehensive inventory of low-frequency variants in Europeans, including SNPs, small insertions and deletions, and structural variants.

The GoT2D consortium has contributed to these datasets in the T2D Knowledge Portal:

  • 13K exome sequence analysis
  • GoT2D exome chip analysis
  • GoT2D WGS
  • GoT2D WGS + replication
  • AMP T2D-GENES exome sequence analysis
  • AMP T2D-GENES quantitative trait exome sequence analysis

GoT2D Cohorts

Cohort Total participants T2D cases Controls Ancestry Principal investigator
University of Michigan/Finnish (METSIM, FUSION, Finrisk, D2D, Dr's Extra) 15,369 4,731 10,638 European Markku Laakso (METSIM)
Lori Bonnycastle (FUSION)
Erkki Vartiainen (Finrisk)
Johan Erikssson (D2D)
Rainer Rauramaa (Dr's Extra)
Broad-Finnish DIREVA/PPP 7,638 3,472 4,166 European Leif Groop (DIREVA)
Tiinamaija Tuomi (PPP)
Broad/PMB-Swedish/ANDIS/SDR 11,131 6,108 5,023 European Leif Groop
Pedersen/Denmark 16,000 5,000 11,000 European Oluf Pedersen
BC58 6,000 0 6,000 European Panos Deloukas
Mark McCarthy
Umeå/Franks 2,000 1,000 1,000 European Paul Franks
KORA 5,000 2,500 2,500 European Thomas Meitinger
Exeter 2,913 1,446 1,567 European Timothy Frayling
EGCUT 4,000 2,000 2,000 European Andres Metspalu
Frank Hu et al. 6,000 3,000< 3,000 European Frank Hu
Nick Wareham et al. 2,500 900 1,600 European Nicholas J Wareham
EPIC Norfolk 1,000 1,000 0 European Nicholas J Wareham
FUSION 958 472 486 European Lori Bonnycastle
KORA-gen 187 97 90 European Thomas Meitinger
UKT2D Consortium 642 322 320 European Mark McCarthy
Timothy Spector
PPP-Malmo-Botnia Study 921 478 443 European Leif Groop
Peter Nilsson
Tiinamaija Tuomi

GoT2D Consortium Members

Broad Institute Jason Flannick
Alisa Manning
Christopher Hartl
Vineeta Agarwala
Pierre Fontanillas
Todd Green
Eric Banks
Mark DePristo
Ryan Poplin
Khalid Shakir
Timothy Fennell
Pål R. Njølstad (Bergen)
Noël Burtt
Stacey Gabriel
David Altshuler
FUSION (Finland-United States Investigation of NIDDM Genetics) Christian Fuchsberger
Hyun Min Kang
Xueling Sim
Clement Ma
Adam Locke
Thomas Blackwell
Anne Jackson
Tanya Teslovich
Heather Stringham
Peter Chines
Phoenix Kwan
Jeroen Huyghe
Adrian Tan
Goo Jun
Michael Stitzel
Richard N. Bergman
Lori Bonnycastle
Jaakko Tuomilehto
Francis S. Collins
Laura Scott
Karen Mohlke
Gonçalo Abecasis
Michael Boehnke
Helmholtz München/KORA Tim Strom
Christian Gieger
Martina Müller-Nurasyid
Harald Grallert
Jennifer Kriebel
Janina Ried
Martin Hrabé de Angelis
Cornelia Huth
Christa Meisinger
Annette Peters
Wolfgang Rathmann
Konstantin Strauch
Thomas Meitinger
Lund University Jasmina Kravic
Peter Algren
Claes Ladenvall
Tiinamaija Toumi
Bo Isomaa
Leif Groop
University of Oxford/UK Kyle Gaulton
Loukas Moutsianas
Manny Rivas
Richard Pearson
Anubha Mahajan
Inga Prokopenko
Ashish Kumar
John Perry
Bryan Howie (Chicago)
Martijn van de Bunt
Kerrin Small (Kings)
Cecilia Lindgren
Gerton Lunter
Neil Robertson
Will Rayner
Andrew Morris
David Buck
Andrew Hattersley (Exeter)
Tim Spector (Kings)
Gil McVean
Tim Frayling (Exeter)
Peter Donnelly
Mark McCarthy