The Accelerating Medicines Partnership® in Common Metabolic Diseases (AMP-CMD) is a public-private partnership to identify drivers of common metabolic diseases, including nonalcoholic steatohepatitis, chronic kidney disease, obesity, atherosclerotic cardiovascular disease, heart failure, type 2 diabetes/prediabetes, autoimmune diabetes, and inflammation. AMP-CMD supports the generation and analysis of genetic association results, epigenomic annotations, and functional studies, and the representation of these results in the open-access Common Metabolic Diseases Knowledge Portal.
The current 5-year AMP-CMD award includes funding for an annual opportunity pool (OP) to support projects to address research directions that would further consortium goals but are not currently ongoing in the consortium. The OP comprises $500,000 total cost for each of the 5 years of the AMP-CMD award. The OP funds are allocated from the NIDDK limited competition award (UM1DK105554), and OP project awards are administered by the Broad Institute. In this round (Summer 2023), applications for year 4 are being considered.
While we welcome proposals from AMP-CMD members, we are also soliciting applications directly from external researchers. Consortium members are encouraged to include external partners as collaborators in proposed OP projects, and external partners are encouraged to consult with and/or include Consortium members as collaborators in proposed OP projects.
AMP-CMD now invites proposals for projects to be supported in year 4 of the OP.
This FOA seeks novel approaches to work with the consortium to identify the functional mechanisms underlying associations for cardiometabolic diseases and related traits. Topics of interest include, but are not limited to
- Novel computational tools to better identify effector transcripts
- Improved cell models to analyze gene function
- Improved cell assays to analyze effector transcript functions in cardiometabolic cell types (adipocytes, myocytes, etc)
This is a two-year project period with a budget cap of $250,000 total (direct and F&A) cost. Details on the four parts of the application, due September 5, 2023, and how to apply are available in the Opportunity Pool Handbook. Please direct any inquiries to "amp-cmd-opportunity-pool(at)broadinstitute.org".