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Publications
Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.
Li JH, Brenner L, Kaur V, et al.
Diabetologia. 2023 Jul;66(7):1260-1272. doi: 10.1007/s00125-023-05922-7.
PMID: 37233759
Phenotypes
SULFONYLUREA RESPONSE:
- Glucose at 30 min at V1
- Glucose at 60 min at V1
- Glucose at 90 min at V1
- Glucose at 120 min at V1
- Glucose at 180 min at V1
- Glucose at 240 min at V1
- Log (fasting glucose at V1 - trough glucose) over (time to glucose trough)
- Log (glucose at 240 min - trough glucose) over (time to glucose trough)
- Log of insulin at 30 min at V1
- Log of insulin at 60 min at V1
- Log of insulin at 90 min at V1
- Log of insulin at 120 min at V1
- Log of insulin at 180 min at V1
- Log of insulin at 240 min at V1
- Log of peak insulin at V1
- Glucose minimum after glipizide treament
- Time to insulin peak after glipizide treatment
- Time to glucose minimum after glipizide treatment
METFORMIN RESPONSE:
- Fasting glucose at V2
- Fasting glucose at V2 minus fasting glucose at V1
- Glucose at 30 min at V2
- Glucose at 60 min at V2
- Glucose at 120 min at V2
- Log of fasting insulin at V2
- Fasting insulin at V2 minus fasting insulin at V1
- Log of insulin at 30 min at V2
- Log of insulin at 60 min at V2
- Log of insulin at 120 min at V2
- Area under the curve of insulin at V2 adj fasting insulin at V2
- HOMA-B at V2 minus HOMA-B at V1
- HOMA-IR at V2 minus HOMA-IR at V1
Project
The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH) is a pharmacogenetic study in which 890 individuals of diverse ancestries who were naive to type 2 diabetes (T2D) medications received a single-dose glipizide challenge and a short course of metformin, with the goal of comprehensively identifying novel genetic predictors of acute metformin and glipizide response in individuals at risk of T2D but naive to these medications.