Variant_ID	Trait	Gene	Cohort	Codon_change	Variant_consequence	ClinVar_classification	Effect_size	Minor_allele_count	gnomAD_minor_allele_frequency	Variant_identifier
1:55043896:C:A	LDL-C	PCSK9	UKBB	c.261C>A (p.His87Gln)	missense_variant	Uncertain Significance	20.45 [30.46] mg/dL	1	NA	NA
1:55043925:G:A	LDL-C	PCSK9	FOURIER	c.290G>A (p.Arg97His)	missense_variant	Conflicting	41.95 [19.37] mg/dL	2	1.39E-04	rs376385276
1:55043933:G:A	LDL-C	PCSK9	UKBB	c.298G>A (p.Ala100Thr)	missense_variant	Uncertain Significance	27.09 [21.54] mg/dL	2	2.79E-05	rs564681731
1:55046617:G:T	LDL-C	PCSK9	UKBB	c.494G>T (p.Arg165Leu)	missense_variant	Uncertain Significance	50.53 [30.46] mg/dL	1	1.99E-05	rs372165281
1:55052411:G:A	LDL-C	PCSK9	UKBB	c.657G>A (p.Gln219=)	synonymous_variant	Uncertain Significance	22.12 [30.46] mg/dL	1	NA	rs1431852989
1:55052650:G:A	LDL-C	PCSK9	UKBB	c.658G>A (p.Ala220Thr)	missense_variant	Uncertain Significance	45.51 [21.54] mg/dL	2	1.20E-05	rs768795323
1:55052771:C:T	LDL-C	PCSK9	UKBB	c.779C>T (p.Thr260Met)	missense_variant	Uncertain Significance	18.64 [21.54] mg/dL	2	1.61E-05	rs777111934
1:55056154:G:A	LDL-C	PCSK9	UKBB	c.961G>A (p.Asp321Asn)	missense_variant	Uncertain Significance	24.2 [30.46] mg/dL	1	NA	rs780509319
1:55057433:G:C	LDL-C	PCSK9	UKBB	c.1099G>C (p.Asp367His)	missense_variant	Conflicting	38.44 [12.44] mg/dL	6	2.31E-04	rs141867978
1:55058131:G:A	LDL-C	PCSK9	UKBB	c.1276G>A (p.Glu426Lys)	missense_variant	Uncertain Significance	23.06 [21.54] mg/dL	2	NA	rs1207777134
1:55058158:G:T	LDL-C	PCSK9	UKBB	c.1303G>T (p.Val435Leu)	missense_variant	Uncertain Significance	19.22 [11.51] mg/dL	7	1.99E-05	rs780948835
1:55058630:C:T	LDL-C	PCSK9	UKBB	c.1486C>T (p.Arg496Trp)	missense_variant	Conflicting	33.19 [6.99] mg/dL	19	4.44E-05	rs374603772
1:55058647:G:A	LDL-C	PCSK9	UKBB	c.1503G>A (p.Glu501=)	synonymous_variant	Uncertain Significance	22.78 [30.46] mg/dL	1	4.17E-06	rs986151799
1:55059522:G:A	LDL-C	PCSK9	UKBB	c.1540G>A (p.Ala514Thr)	missense_variant	Uncertain Significance	53.49 [30.46] mg/dL	1	5.75E-06	rs1447116791
1:55059529:G:T	LDL-C	PCSK9	UKBB	c.1547G>T (p.Gly516Val)	missense_variant	Uncertain Significance	98.27 [23.69] mg/dL	2	NA	rs891322948
1:55059603:C:T	LDL-C	PCSK9	UKBB	c.1621C>T (p.Pro541Ser)	missense_variant	Uncertain Significance	96.55 [30.46] mg/dL	1	6.33E-06	rs369996097
1:55061426:T:A	LDL-C	PCSK9	UKBB	c.1733T>A (p.Val578Glu)	missense_variant	Uncertain Significance	20.98 [21.56] mg/dL	2	3.30E-05	rs765583923
1:55061428:C:A	LDL-C	PCSK9	UKBB	c.1735C>A (p.Leu579Met)	missense_variant	Uncertain Significance	53.09 [30.47] mg/dL	1	4.13E-06	rs751217094
1:55061449:A:G	LDL-C	PCSK9	UKBB	c.1756A>G (p.Asn586Asp)	missense_variant	Uncertain Significance	23.41 [15.89] mg/dL	4	4.18E-06	rs146035580
1:55061458:G:A	LDL-C	PCSK9	FOURIER	c.1765G>A (p.Val589Met)	missense_variant	Uncertain Significance	29.93 [27.22] mg/dL	1	NA	rs372586224
11:2445453:G:C	QTc	KCNQ1	UKBB	c.355G>C (p.Gly119Arg)	missense_variant	Conflicting	46.52 [23.07] ms	1	NA	rs1325525794
11:2527978:A:G	QTc	KCNQ1	TOPMed	c.437A>G (p.Glu146Gly)	missense_variant	Conflicting	19.85 [15.8] ms	2	3.98E-06	rs914460959
11:2570634:G:A	QTc	KCNQ1	UKBB	c.484G>A (p.Val162Met)	missense_variant	Uncertain Significance	21.34 [23.08] ms	1	1.60E-05	rs199472692
11:2570664:G:A	QTc	KCNQ1	TOPMed	c.133G>A (p.Val45Met)	missense_variant	Conflicting	24.15 [21.77] ms	1	5.21E-05	rs199472694
11:2570685:G:A	QTc	KCNQ1	TOPMed	c.535G>A (p.Gly179Ser)	missense_variant	Conflicting	30.04 [22.27] ms	1	NA	rs199473394
11:2571391:C:T	QTc	KCNQ1	TOPMed	c.290C>T (p.Thr97Met)	missense_variant	Conflicting	22.82 [4.75] ms	23	4.02E-06	rs199472706
11:2572050:G:A	QTc	KCNQ1	UKBB	c.340G>A (p.Val114Ile)	missense_variant	Uncertain Significance	13.61 [23.07] ms	1	1.20E-05	rs199956744
11:2572942:C:T	QTc	KCNQ1	UKBB	c.496C>T (p.Arg166Cys)	missense_variant	Conflicting	20 [11.53] ms	4	3.60E-05	rs199472737
11:2572943:G:A	QTc	KCNQ1	UKBB	c.497G>A (p.Arg166His)	missense_variant	Conflicting	19.98 [23.08] ms	1	1.60E-05	rs199473465
11:2572963:G:A	QTc	KCNQ1	UKBB	c.517G>A (p.Ala173Thr)	missense_variant	Conflicting	33.63 [16.43] ms	2	4.80E-05	rs120074187
11:2572963:G:A	QTc	KCNQ1	TOPMed	c.517G>A (p.Ala173Thr)	missense_variant	Conflicting	20.18 [15.53] ms	2	4.80E-05	rs120074187
11:2572965:A:C	QTc	KCNQ1	UKBB	c.900A>C (p.Ala300=)	synonymous_variant	Conflicting	16.44 [9.42] ms	6	0.000104	rs727504769
11:2572965:A:C	QTc	KCNQ1	TOPMed	c.900A>C (p.Ala300=)	synonymous_variant	Conflicting	22.26 [12.99] ms	3	0.000104	rs727504769
11:2587603:G:A	QTc	KCNQ1	UKBB	c.1162G>A (p.Asp388Asn)	missense_variant	Uncertain Significance	44.11 [23.06] ms	1	7.96E-06	rs537637760
11:2587618:A:G	QTc	KCNQ1	UKBB	c.1177A>G (p.Lys393Glu)	missense_variant	Uncertain Significance	20.45 [23.06] ms	1	NA	NA
11:2587630:C:T	QTc	KCNQ1	TOPMed	c.808C>T (p.Arg270Trp)	missense_variant	Conflicting	12.32 [7.41] ms	9	1.99E-04	rs199472776
11:2587679:A:G	QTc	KCNQ1	TOPMed	c.1238A>G (p.Lys413Arg)	missense_variant	Uncertain Significance	12.68 [9.78] ms	5	7.96E-06	rs1351149628
11:2587679:A:G	QTc	KCNQ1	UKBB	c.1238A>G (p.Lys413Arg)	missense_variant	Uncertain Significance	16.52 [23.07] ms	1	7.96E-06	rs1351149628
11:2587687:G:A	QTc	KCNQ1	UKBB	c.1246G>A (p.Val416Met)	missense_variant	Uncertain Significance	12.63 [23.06] ms	1	1.19E-05	rs777546418
11:2588804:C:A	QTc	KCNQ1	UKBB	c.962C>A (p.Pro321Gln)	missense_variant	Uncertain Significance	14.02 [16.32] ms	2	7.19E-05	rs12720449
11:2588815:C:T	QTc	KCNQ1	TOPMed	c.973C>T (p.Arg325Trp)	missense_variant	Conflicting	21.21 [6.24] ms	13	8.01E-05	rs140452381
11:2588815:C:T	QTc	KCNQ1	UKBB	c.973C>T (p.Arg325Trp)	missense_variant	Conflicting	15.2 [23.07] ms	1	8.01E-05	rs140452381
11:2588836:G:A	QTc	KCNQ1	TOPMed	c.994G>A (p.Asp332Asn)	missense_variant	Conflicting	14.66 [12.72] ms	3	3.61E-05	rs747704276
11:2588840:G:A	QTc	KCNQ1	TOPMed	c.1379G>A (p.Gly460Asp)	missense_variant	Uncertain Significance	19.29 [21.7] ms	1	1.20E-05	rs770410327
11:2588849:G:C	QTc	KCNQ1	UKBB	c.1007G>C (p.Ser336Thr)	missense_variant	Uncertain Significance	25.39 [23.09] ms	1	3.62E-05	rs184636161
11:2662065:A:G	QTc	KCNQ1	UKBB	c.1498A>G (p.Ile500Val)	missense_variant	Uncertain Significance	15.24 [23.07] ms	1	3.98E-06	rs189794855
11:2768849:G:A	QTc	KCNQ1	TOPMed	c.1139G>A (p.Arg380Gln)	missense_variant	Uncertain Significance	28.15 [15.79] ms	2	4.77E-05	rs369571296
11:2768861:G:A	QTc	KCNQ1	UKBB	c.1151G>A (p.Arg384Gln)	missense_variant	Uncertain Significance	26.3 [23.06] ms	1	7.96E-06	rs753962384
11:2768881:C:T	QTc	KCNQ1	UKBB	c.1552C>T (p.Arg518Ter)	stop_gained	Conflicting	45.45 [6.96] ms	11	1.03E-04	rs17215500
11:2768881:C:T	QTc	KCNQ1	TOPMed	c.1552C>T (p.Arg518Ter)	stop_gained	Conflicting	66.53 [22.29] ms	1	1.03E-04	rs17215500
11:2768905:A:G	QTc	KCNQ1	TOPMed	c.1195A>G (p.Lys399Glu)	missense_variant	Uncertain Significance	91.16 [21.78] ms	1	7.96E-06	rs199472792
11:2777026:G:A	QTc	KCNQ1	TOPMed	c.1726G>A (p.Val576Ile)	missense_variant	Conflicting	14.57 [15.45] ms	2	6.37E-05	rs750409379
12:120989027:C:T	HbA1c	HNF1A	UKBB	c.521C>T (p.Ala174Val)	missense_variant	Uncertain Significance	0.34 [0.18] (%)	7	2.00E-04	rs201934320
12:120994373:C:T	HbA1c	HNF1A	UKBB	c.923C>T (p.Pro308Leu)	missense_variant	Uncertain Significance	0.31 [0.49] (%)	1	2.81E-05	rs754306821
17:37710624:G:A	HbA1c	HNF1B	FOURIER	c.1085C>T (p.Ser362Phe)	missense_variant	Uncertain Significance	2.71 [0.89] (%)	1	NA	rs1024639436
17:37731615:G:A	HbA1c	HNF1B	FOURIER	c.1025C>T (p.Ser342Phe)	missense_variant	Conflicting	0.48 [0.63] (%)	2	3.22E-05	rs780035561
17:37731712:G:A	HbA1c	HNF1B	UKBB	c.928C>T (p.Arg310Trp)	missense_variant	Uncertain Significance	0.34 [0.49] (%)	1	NA	rs988279557
17:37733616:G:A	HbA1c	HNF1B	FOURIER	c.750C>T (p.Tyr250=)	synonymous_variant	Conflicting	0.64 [0.89] (%)	1	9.15E-05	rs144249535
19:11100236:C:G	LDL-C	LDLR	FOURIER	c.81C>G (p.Cys27Trp)	missense_variant	Conflicting	16.99 [8.27] mg/dL	9	1.60E-05	rs2228671
19:11100236:C:G	LDL-C	LDLR	UKBB	c.81C>G (p.Cys27Trp)	missense_variant	Conflicting	53.69 [21.54] mg/dL	2	1.60E-05	rs2228671
19:11100237:G:A	LDL-C	LDLR	UKBB	c.82G>A (p.Glu28Lys)	missense_variant	Conflicting	37.68 [30.46] mg/dL	1	3.15E-04	rs551747280
19:11100246:G:A	LDL-C	LDLR	UKBB	c.91G>A (p.Glu31Lys)	missense_variant	Conflicting	20.25 [10.15] mg/dL	9	2.39E-05	rs776421777
19:11100294:G:A	LDL-C	LDLR	UKBB	c.139G>A (p.Asp47Asn)	missense_variant	Conflicting	21.2 [12.37] mg/dL	6	1.59E-05	rs778284147
19:11100303:G:A	LDL-C	LDLR	FOURIER	c.148G>A (p.Ala50Thr)	missense_variant	Conflicting	17.46 [12.25] mg/dL	5	6.77E-05	rs137853960
19:11100308:G:C	LDL-C	LDLR	UKBB	c.153G>C (p.Glu51Asp)	missense_variant	Uncertain Significance	22.73 [15.23] mg/dL	4	3.98E-06	rs772188884
19:11102684:G:A	LDL-C	LDLR	UKBB	c.211G>A (p.Gly71Arg)	missense_variant	Conflicting	19.08 [17.59] mg/dL	3	2.39E-05	rs766903209
19:11102699:G:T	LDL-C	LDLR	UKBB	c.226G>T (p.Gly76Trp)	missense_variant	Conflicting	37.84 [17.59] mg/dL	3	NA	rs574337291
19:11102714:C:T	LDL-C	LDLR	UKBB	c.241C>T (p.Arg81Cys)	missense_variant	Conflicting	63.66 [17.84] mg/dL	3	7.95E-06	rs730882078
19:11102741:G:A	LDL-C	LDLR	UKBB	c.268G>A (p.Asp90Asn)	missense_variant	Conflicting	21.5 [12.43] mg/dL	6	5.57E-05	rs749038326
19:11102786:C:T	LDL-C	LDLR	UKBB	c.313C>T (p.Pro105Ser)	missense_variant	Conflicting	17.07 [21.54] mg/dL	2	7.95E-05	rs13306510
19:11102787:G:A	LDL-C	LDLR	UKBB	c.313+1G>A	splice_donor_variant	Conflicting	74.78 [13.62] mg/dL	5	2.78E-05	rs112029328
19:11102787:G:A	LDL-C	LDLR	FOURIER	c.313+1G>A	splice_donor_variant	Conflicting	115.08 [19.28] mg/dL	2	2.78E-05	rs112029328
19:11102788:T:C	LDL-C	LDLR	FOURIER	c.313+2T>C	splice_donor_variant	Conflicting	22.38 [19.2] mg/dL	2	NA	rs793888517
19:11105243:G:A	LDL-C	LDLR	UKBB	c.337G>A (p.Glu113Lys)	missense_variant	Conflicting	30.63 [8.44] mg/dL	13	2.79E-05	rs769383881
19:11105243:G:A	LDL-C	LDLR	FOURIER	c.337G>A (p.Glu113Lys)	missense_variant	Conflicting	17.56 [19.11] mg/dL	2	2.79E-05	rs769383881
19:11105249:C:T	LDL-C	LDLR	UKBB	c.343C>T (p.Arg115Cys)	missense_variant	Conflicting	19.7 [21.54] mg/dL	2	2.79E-05	rs774723292
19:11105357:G:C	LDL-C	LDLR	FOURIER	c.451G>C (p.Ala151Pro)	missense_variant	Uncertain Significance	33.34 [27.3] mg/dL	1	1.19E-05	rs763233960
19:11105470:C:T	LDL-C	LDLR	FOURIER	c.564C>T (p.Tyr188=)	synonymous_variant	Conflicting	27.02 [27.46] mg/dL	1	8.75E-05	rs121908034
19:11105538:A:T	LDL-C	LDLR	FOURIER	c.632A>T (p.His211Leu)	missense_variant	Conflicting	44.53 [27.39] mg/dL	1	NA	rs879254603
19:11106588:G:A	LDL-C	LDLR	UKBB	c.718G>A (p.Glu240Lys)	missense_variant	Conflicting	31.21 [6.49] mg/dL	22	2.78E-05	rs768563000
19:11106601:C:G	LDL-C	LDLR	UKBB	c.731C>G (p.Ser244Cys)	missense_variant	Uncertain Significance	68.28 [21.54] mg/dL	2	NA	rs1208667598
19:11106668:T:A	LDL-C	LDLR	FOURIER	c.798T>A (p.Asp266Glu)	missense_variant	Conflicting	23.41 [7.07] mg/dL	15	3.18E-05	rs139043155
19:11107432:C:A	LDL-C	LDLR	UKBB	c.858C>A (p.Ser286Arg)	missense_variant	Conflicting	92.05 [21.51] mg/dL	2	2.78E-05	rs140241383
19:11107432:C:A	LDL-C	LDLR	FOURIER	c.858C>A (p.Ser286Arg)	missense_variant	Conflicting	83.53 [27.39] mg/dL	1	2.78E-05	rs140241383
19:11107436:G:A	LDL-C	LDLR	UKBB	c.862G>A (p.Glu288Lys)	missense_variant	Conflicting	36.14 [15.23] mg/dL	4	3.98E-05	rs368657165
19:11107445:A:C	LDL-C	LDLR	UKBB	c.871A>C (p.Thr291Pro)	missense_variant	Uncertain Significance	32.67 [30.46] mg/dL	1	3.98E-06	rs766754788
19:11107472:A:G	LDL-C	LDLR	UKBB	c.898A>G (p.Arg300Gly)	missense_variant	Conflicting	69.27 [21.54] mg/dL	2	1.19E-05	rs767618089
19:11107506:A:G	LDL-C	LDLR	FOURIER	c.932A>G (p.Lys311Arg)	missense_variant	Conflicting	44.82 [15.75] mg/dL	3	NA	rs761765254
19:11107513:C:G	LDL-C	LDLR	FOURIER	c.939C>G (p.Cys313Trp)	missense_variant	Conflicting	44.82 [15.75] mg/dL	3	3.99E-06	rs13306512
19:11110681:G:T	LDL-C	LDLR	UKBB	c.970G>T (p.Gly324Cys)	missense_variant	Uncertain Significance	38.07 [30.47] mg/dL	1	NA	NA
19:11110690:C:T	LDL-C	LDLR	UKBB	c.979C>T (p.His327Tyr)	missense_variant	Conflicting	50.43 [12.43] mg/dL	6	5.98E-05	rs747507019
19:11110697:G:A	LDL-C	LDLR	FOURIER	c.986G>A (p.Cys329Tyr)	missense_variant	Conflicting	65.61 [26.89] mg/dL	1	1.59E-05	rs761954844
19:11110735:G:A	LDL-C	LDLR	FOURIER	c.1024G>A (p.Asp342Asn)	missense_variant	Conflicting	41.27 [27.34] mg/dL	1	4.54E-04	rs139361635
19:11110738:G:A	LDL-C	LDLR	UKBB	c.1027G>A (p.Gly343Ser)	missense_variant	Conflicting	21.58 [10.15] mg/dL	9	2.79E-05	rs730882096
19:11110738:G:A	LDL-C	LDLR	FOURIER	c.1027G>A (p.Gly343Ser)	missense_variant	Conflicting	17.4 [15.75] mg/dL	3	2.79E-05	rs730882096
19:11110760:G:C	LDL-C	LDLR	UKBB	c.1049G>C (p.Arg350Pro)	missense_variant	Conflicting	41.9 [13.48] mg/dL	5	NA	rs875989914
19:11111518:C:G	LDL-C	LDLR	UKBB	c.1065C>G (p.Ile355Met)	missense_variant	Uncertain Significance	35.11 [30.46] mg/dL	1	7.96E-06	rs960032925
19:11111609:G:T	LDL-C	LDLR	UKBB	c.1156G>T (p.Asp386Tyr)	missense_variant	Uncertain Significance	19.81 [12.39] mg/dL	6	3.98E-06	rs1402951356
19:11111611:C:G	LDL-C	LDLR	FOURIER	c.1158C>G (p.Asp386Glu)	missense_variant	Conflicting	102.58 [27.66] mg/dL	1	NA	rs879254810
19:11111619:C:T	LDL-C	LDLR	UKBB	c.1166C>T (p.Thr389Met)	missense_variant	Conflicting	18.29 [10.15] mg/dL	9	1.99E-05	rs149227308
19:11113280:T:C	LDL-C	LDLR	UKBB	c.1189T>C (p.Ser397Pro)	missense_variant	Uncertain Significance	21.02 [30.46] mg/dL	1	NA	NA
19:11113292:CTCT:C	LDL-C	LDLR	UKBB	c.1204_1206TTC[1] (p.Phe403del)	inframe_deletion	Conflicting	41.83 [30.46] mg/dL	1	NA	rs879254830
19:11113308:G:A	LDL-C	LDLR	UKBB	c.1217G>A (p.Arg406Gln)	missense_variant	Conflicting	34.93 [17.58] mg/dL	3	1.59E-05	rs552422789
19:11113329:C:T	LDL-C	LDLR	UKBB	c.1238C>T (p.Thr413Met)	missense_variant	Conflicting	33.45 [6.81] mg/dL	20	2.79E-05	rs368562025
19:11113329:C:T	LDL-C	LDLR	FOURIER	c.1238C>T (p.Thr413Met)	missense_variant	Conflicting	24.3 [27.64] mg/dL	1	2.79E-05	rs368562025
19:11113398:T:C	LDL-C	LDLR	FOURIER	c.1307T>C (p.Val436Ala)	missense_variant	Conflicting	20.14 [15.83] mg/dL	3	1.19E-05	rs779732323
19:11113419:G:C	LDL-C	LDLR	UKBB	c.1328G>C (p.Trp443Ser)	missense_variant	Conflicting	51.57 [30.46] mg/dL	1	NA	rs879254866
19:11113426:C:G	LDL-C	LDLR	UKBB	c.1335C>G (p.Asp445Glu)	missense_variant	Uncertain Significance	27.67 [10.77] mg/dL	8	NA	rs749780672
19:11113560:G:A	LDL-C	LDLR	UKBB	c.1384G>A (p.Val462Ile)	missense_variant	Conflicting	31.47 [15.23] mg/dL	4	5.58E-05	rs750363970
19:11113590:G:A	LDL-C	LDLR	UKBB	c.1414G>A (p.Asp472Asn)	missense_variant	Conflicting	42.78 [17.66] mg/dL	3	NA	rs730882102
19:11113590:G:T	LDL-C	LDLR	UKBB	c.1414G>T (p.Asp472Tyr)	missense_variant	Conflicting	29.97 [10.77] mg/dL	8	5.57E-05	rs730882102
19:11113605:G:A	LDL-C	LDLR	UKBB	c.1429G>A (p.Asp477Asn)	missense_variant	Uncertain Significance	23.75 [30.47] mg/dL	1	3.98E-06	rs780316072
19:11113605:G:A	LDL-C	LDLR	FOURIER	c.1429G>A (p.Asp477Asn)	missense_variant	Uncertain Significance	26.92 [27.27] mg/dL	1	3.98E-06	rs780316072
19:11113608:G:A	LDL-C	LDLR	UKBB	c.1432G>A (p.Gly478Arg)	missense_variant	Conflicting	20.3 [21.54] mg/dL	2	2.79E-05	rs144614838
19:11113608:G:A	LDL-C	LDLR	FOURIER	c.1432G>A (p.Gly478Arg)	missense_variant	Conflicting	472.8 [27.21] mg/dL	1	2.79E-05	rs144614838
19:11113636:A:G	LDL-C	LDLR	FOURIER	c.1460A>G (p.Asn487Ser)	missense_variant	Conflicting	18.86 [27.53] mg/dL	1	NA	rs879254912
19:11113679:G:A	LDL-C	LDLR	UKBB	c.1503G>A (p.Ala501=)	synonymous_variant	Conflicting	28.88 [17.35] mg/dL	3	3.18E-05	rs368889457
19:11116197:A:G	LDL-C	LDLR	FOURIER	c.1690A>G (p.Asn564Asp)	missense_variant	Conflicting	54.47 [27.19] mg/dL	1	NA	rs397509365
19:11116873:C:T	LDL-C	LDLR	UKBB	c.1720C>T (p.Arg574Cys)	missense_variant	Conflicting	26.12 [15.15] mg/dL	4	3.18E-05	rs185098634
19:11116874:G:T	LDL-C	LDLR	UKBB	c.1721G>T (p.Arg574Leu)	missense_variant	Conflicting	50.84 [30.46] mg/dL	1	1.59E-05	rs777188764
19:11116900:C:T	LDL-C	LDLR	UKBB	c.1747C>T (p.His583Tyr)	missense_variant	Conflicting	21.12 [13.64] mg/dL	5	1.07E-04	rs730882109
19:11116918:G:A	LDL-C	LDLR	UKBB	c.1765G>A (p.Asp589Asn)	missense_variant	Uncertain Significance	27.02 [17.57] mg/dL	3	8.35E-05	rs201971888
19:11116936:C:T	LDL-C	LDLR	UKBB	c.1783C>T (p.Arg595Trp)	missense_variant	Conflicting	44.31 [10.77] mg/dL	8	3.98E-06	rs373371572
19:11116937:G:A	LDL-C	LDLR	UKBB	c.1784G>A (p.Arg595Gln)	missense_variant	Conflicting	42.86 [21.54] mg/dL	2	3.98E-05	rs201102492
19:11116949:T:C	LDL-C	LDLR	UKBB	c.1796T>C (p.Leu599Ser)	missense_variant	Conflicting	68.31 [15.23] mg/dL	4	NA	rs879255025
19:11116969:G:A	LDL-C	LDLR	UKBB	c.1816G>A (p.Ala606Thr)	missense_variant	Conflicting	58.57 [30.5] mg/dL	1	3.58E-05	rs72658865
19:11120101:T:C	LDL-C	LDLR	UKBB	c.1855T>C (p.Phe619Leu)	missense_variant	Conflicting	30.44 [30.46] mg/dL	1	3.98E-06	rs747134711
19:11120114:T:C	LDL-C	LDLR	UKBB	c.1868T>C (p.Ile623Thr)	missense_variant	Uncertain Significance	19.63 [7.61] mg/dL	16	1.59E-05	rs141155833
19:11120158:G:A	LDL-C	LDLR	UKBB	c.1912G>A (p.Asp638Asn)	missense_variant	Uncertain Significance	23.95 [21.54] mg/dL	2	1.59E-05	rs757672647
19:11120212:C:A	LDL-C	LDLR	UKBB	c.1966C>A (p.His656Asn)	missense_variant	Conflicting	19.47 [11.51] mg/dL	7	1.19E-05	rs762815611
19:11120212:C:A	LDL-C	LDLR	FOURIER	c.1966C>A (p.His656Asn)	missense_variant	Conflicting	25.75 [27.27] mg/dL	1	1.19E-05	rs762815611
19:11120441:A:T	LDL-C	LDLR	UKBB	c.2059A>T (p.Ile687Phe)	missense_variant	Uncertain Significance	45.67 [13.62] mg/dL	5	3.98E-06	rs1060499932
19:11120454:C:T	LDL-C	LDLR	UKBB	c.2072C>T (p.Ser691Leu)	missense_variant	Uncertain Significance	34.61 [13.62] mg/dL	5	2.79E-05	rs369943481
19:11120478:C:T	LDL-C	LDLR	UKBB	c.2096C>T (p.Pro699Leu)	missense_variant	Conflicting	27.87 [17.59] mg/dL	3	1.99E-05	rs201573863
19:11120480:G:A	LDL-C	LDLR	UKBB	c.2098G>A (p.Asp700Asn)	missense_variant	Uncertain Significance	40.18 [10.76] mg/dL	8	1.99E-05	rs375009082
19:11123315:C:T	LDL-C	LDLR	UKBB	c.2282C>T (p.Thr761Met)	missense_variant	Conflicting	20.22 [7.7] mg/dL	16	5.17E-05	rs138477254
19:11128008:C:T	LDL-C	LDLR	UKBB	c.2312C>T (p.Ala771Val)	missense_variant	Conflicting	24.87 [30.42] mg/dL	1	3.18E-05	rs113972139
19:11128019:G:A	LDL-C	LDLR	UKBB	c.2323G>A (p.Val775Ile)	missense_variant	Uncertain Significance	36.26 [17.59] mg/dL	3	2.78E-05	rs199766976
19:11128085:G:A	LDL-C	LDLR	UKBB	c.2389G>A (p.Val797Met)	missense_variant	Conflicting	83.76 [30.46] mg/dL	1	7.96E-06	rs750518671
19:11128085:G:T	LDL-C	LDLR	FOURIER	c.2389G>T (p.Val797Leu)	missense_variant	Conflicting	89.14 [19.34] mg/dL	2	NA	rs750518671
19:11129534:T:TG	LDL-C	LDLR	UKBB	c.2416dup (p.Val806fs)	frameshift_variant	Conflicting	28.31 [30.46] mg/dL	1	2.39E-05	rs773618064
19:11129534:T:TG	LDL-C	LDLR	FOURIER	c.2416dup (p.Val806fs)	frameshift_variant	Conflicting	133.9 [27.61] mg/dL	1	2.39E-05	rs773618064
19:11129635:A:G	LDL-C	LDLR	UKBB	c.2512A>G (p.Ile838Val)	missense_variant	Uncertain Significance	17.07 [30.46] mg/dL	1	NA	rs1600765567
19:11129670:G:A	LDL-C	LDLR	UKBB	c.2547G>A (p.Ser849=)	synonymous_variant	Uncertain Significance	26.56 [21.54] mg/dL	2	3.98E-06	rs1249903899
2:21004403:C:T	LDL-C	APOB	UKBB	c.11953G>A (p.Asp3985Asn)	missense_variant	Uncertain Significance	26.27 [11.51] mg/dL	7	5.97E-05	rs772544842
2:21004610:G:A	LDL-C	APOB	UKBB	c.11854C>T (p.Arg3952Cys)	missense_variant	Uncertain Significance	24.62 [10.15] mg/dL	9	1.59E-05	rs535121944
2:21005124:G:A	LDL-C	APOB	UKBB	c.11744C>T (p.Ser3915Phe)	missense_variant	Uncertain Significance	19.2 [21.55] mg/dL	2	1.99E-05	rs201990496
2:21005293:C:T	LDL-C	APOB	FOURIER	c.11575G>A (p.Glu3859Lys)	missense_variant	Uncertain Significance	19.91 [27.39] mg/dL	1	3.98E-06	rs1378283331
2:21005583:T:G	LDL-C	APOB	UKBB	c.11285A>C (p.Lys3762Thr)	missense_variant	Uncertain Significance	44.52 [30.46] mg/dL	1	2.39E-05	rs753541880
2:21005858:C:G	LDL-C	APOB	UKBB	c.11010G>C (p.Arg3670Ser)	missense_variant	Uncertain Significance	72.93 [30.46] mg/dL	1	3.19E-05	rs148127628
2:21005943:C:T	LDL-C	APOB	UKBB	c.10925G>A (p.Gly3642Glu)	missense_variant	Uncertain Significance	17.74 [15.23] mg/dL	4	NA	NA
2:21005994:T:C	LDL-C	APOB	FOURIER	c.10874A>G (p.Asn3625Ser)	missense_variant	Uncertain Significance	36.6 [27.24] mg/dL	1	NA	NA
2:21006129:T:C	LDL-C	APOB	UKBB	c.10739A>G (p.Asn3580Ser)	missense_variant	Conflicting	23.72 [13.54] mg/dL	5	1.59E-05	rs762028704
2:21006288:C:T	LDL-C	APOB	UKBB	c.10580G>A (p.Arg3527Gln)	missense_variant	Conflicting	51.92 [2.67] mg/dL	131	2.75E-04	rs5742904
2:21006289:G:A	LDL-C	APOB	UKBB	c.10579C>T (p.Arg3527Trp)	missense_variant	Conflicting	20.84 [12.41] mg/dL	6	1.72E-04	rs144467873
2:21006289:G:A	LDL-C	APOB	FOURIER	c.10579C>T (p.Arg3527Trp)	missense_variant	Conflicting	42.51 [15.68] mg/dL	3	1.72E-04	rs144467873
2:21006297:T:G	LDL-C	APOB	UKBB	c.10571A>C (p.Lys3524Thr)	missense_variant	Uncertain Significance	39.29 [11.77] mg/dL	7	3.99E-06	rs750035232
2:21006357:A:G	LDL-C	APOB	UKBB	c.10511T>C (p.Val3504Ala)	missense_variant	Uncertain Significance	25.95 [30.46] mg/dL	1	NA	NA
2:21006382:T:C	LDL-C	APOB	UKBB	c.10486A>G (p.Thr3496Ala)	missense_variant	Uncertain Significance	28.11 [17.46] mg/dL	3	1.99E-05	rs754800464
2:21006382:T:C	LDL-C	APOB	FOURIER	c.10486A>G (p.Thr3496Ala)	missense_variant	Uncertain Significance	93.65 [27.22] mg/dL	1	1.99E-05	rs754800464
2:21006385:A:T	LDL-C	APOB	UKBB	c.10483T>A (p.Ser3495Thr)	missense_variant	Uncertain Significance	40.21 [30.46] mg/dL	1	1.99E-05	rs535977033
2:21006498:G:C	LDL-C	APOB	UKBB	c.10370C>G (p.Ser3457Cys)	missense_variant	Uncertain Significance	19.46 [30.46] mg/dL	1	2.39E-05	rs778985735
2:21006831:C:A	LDL-C	APOB	UKBB	c.10037G>T (p.Ser3346Ile)	missense_variant	Conflicting	43.11 [21.52] mg/dL	2	1.59E-05	rs373190270
2:21006843:G:A	LDL-C	APOB	UKBB	c.10025C>T (p.Ser3342Phe)	missense_variant	Uncertain Significance	17.24 [15.23] mg/dL	4	8.77E-05	rs267599180
2:21007053:T:C	LDL-C	APOB	UKBB	c.9815A>G (p.Tyr3272Cys)	missense_variant	Uncertain Significance	23.47 [29.5] mg/dL	1	1.59E-05	rs1220960430
2:21007153:G:A	LDL-C	APOB	UKBB	c.9715C>T (p.His3239Tyr)	missense_variant	Uncertain Significance	34.76 [21.56] mg/dL	2	3.98E-06	rs755547544
2:21007155:G:A	LDL-C	APOB	UKBB	c.9713C>T (p.Ser3238Phe)	missense_variant	Uncertain Significance	35.04 [30.46] mg/dL	1	1.20E-05	rs777546847
2:21007174:T:C	LDL-C	APOB	UKBB	c.9694A>G (p.Lys3232Glu)	missense_variant	Conflicting	22.44 [11.51] mg/dL	7	1.24E-04	rs544521341
2:21007366:A:T	LDL-C	APOB	UKBB	c.9502T>A (p.Ser3168Thr)	missense_variant	Uncertain Significance	34.76 [21.56] mg/dL	2	3.98E-06	rs761382742
2:21007401:G:T	LDL-C	APOB	UKBB	c.9467C>A (p.Thr3156Lys)	missense_variant	Uncertain Significance	27.37 [17.58] mg/dL	3	3.98E-06	rs747569141
2:21007411:A:G	LDL-C	APOB	UKBB	c.9457T>C (p.Trp3153Arg)	missense_variant	Uncertain Significance	18.16 [21.54] mg/dL	2	7.97E-06	rs761484953
2:21007461:C:T	LDL-C	APOB	UKBB	c.9407G>A (p.Arg3136His)	missense_variant	Uncertain Significance	30.89 [10.71] mg/dL	8	5.18E-05	rs199590149
2:21007629:G:T	LDL-C	APOB	UKBB	c.9239C>A (p.Pro3080His)	missense_variant	Uncertain Significance	23.33 [21.54] mg/dL	2	7.97E-06	rs1429705510
2:21007647:T:C	LDL-C	APOB	FOURIER	c.9221A>G (p.Tyr3074Cys)	missense_variant	Uncertain Significance	23.16 [27.25] mg/dL	1	1.99E-05	rs372902533
2:21007693:G:A	LDL-C	APOB	UKBB	c.9175C>T (p.Arg3059Cys)	missense_variant	Conflicting	72.22 [30.42] mg/dL	1	7.97E-06	rs146377316
2:21007719:G:A	LDL-C	APOB	UKBB	c.9149C>T (p.Thr3050Ile)	missense_variant	Uncertain Significance	74.21 [30.46] mg/dL	1	NA	rs766404863
2:21007773:G:T	LDL-C	APOB	UKBB	c.9095C>A (p.Thr3032Asn)	missense_variant	Uncertain Significance	28.53 [30.46] mg/dL	1	1.99E-05	rs754332101
2:21007788:C:T	LDL-C	APOB	UKBB	c.9080G>A (p.Gly3027Glu)	missense_variant	Uncertain Significance	52.4 [23.91] mg/dL	2	3.98E-06	rs757895045
2:21008090:T:G	LDL-C	APOB	FOURIER	c.8778A>C (p.Lys2926Asn)	missense_variant	Uncertain Significance	28.37 [27.2] mg/dL	1	NA	rs925427080
2:21008148:C:T	LDL-C	APOB	FOURIER	c.8720G>A (p.Arg2907His)	missense_variant	Conflicting	24.26 [13.76] mg/dL	4	5.57E-05	rs751437976
2:21008166:G:C	LDL-C	APOB	UKBB	c.8702C>G (p.Ser2901Cys)	missense_variant	Uncertain Significance	57.44 [30.4] mg/dL	1	NA	NA
2:21008175:A:G	LDL-C	APOB	FOURIER	c.8693T>C (p.Leu2898Pro)	missense_variant	Uncertain Significance	49.26 [27.41] mg/dL	1	2.39E-05	rs376974746
2:21008401:C:A	LDL-C	APOB	UKBB	c.8467G>T (p.Ala2823Ser)	missense_variant	Uncertain Significance	23.01 [13.59] mg/dL	5	3.98E-06	rs1378244531
2:21008474:C:A	LDL-C	APOB	UKBB	c.8394G>T (p.Glu2798Asp)	missense_variant	Uncertain Significance	37.06 [21.54] mg/dL	2	3.98E-06	rs760517113
2:21008625:T:C	LDL-C	APOB	UKBB	c.8243A>G (p.His2748Arg)	missense_variant	Uncertain Significance	20.64 [21.54] mg/dL	2	NA	rs1049705142
2:21008642:C:A	LDL-C	APOB	FOURIER	c.8226G>T (p.Gln2742His)	missense_variant	Uncertain Significance	33.46 [27.3] mg/dL	1	7.97E-06	rs376773500
2:21008734:G:A	LDL-C	APOB	FOURIER	c.8134C>T (p.Arg2712Cys)	missense_variant	Uncertain Significance	21.75 [12.26] mg/dL	5	1.27E-04	rs372245645
2:21008739:T:A	LDL-C	APOB	UKBB	c.8129A>T (p.Asp2710Val)	missense_variant	Uncertain Significance	18.38 [11.58] mg/dL	7	7.96E-06	rs771882254
2:21008806:C:T	LDL-C	APOB	UKBB	c.8062G>A (p.Val2688Ile)	missense_variant	Uncertain Significance	18.36 [12.43] mg/dL	6	1.99E-05	rs756791670
2:21008821:C:G	LDL-C	APOB	FOURIER	c.8047G>C (p.Glu2683Gln)	missense_variant	Uncertain Significance	51.37 [27.38] mg/dL	1	3.98E-06	rs373846203
2:21009091:T:C	LDL-C	APOB	UKBB	c.7777A>G (p.Ile2593Val)	missense_variant	Uncertain Significance	51.96 [30.47] mg/dL	1	7.98E-06	rs758579572
2:21009170:C:G	LDL-C	APOB	UKBB	c.7698G>C (p.Glu2566Asp)	missense_variant	Conflicting	21.95 [9.65] mg/dL	10	1.12E-04	rs149306841
2:21009279:T:G	LDL-C	APOB	UKBB	c.7589A>C (p.Gln2530Pro)	missense_variant	Uncertain Significance	56.41 [21.55] mg/dL	2	3.98E-06	rs1489058435
2:21009298:A:G	LDL-C	APOB	FOURIER	c.7570T>C (p.Tyr2524His)	missense_variant	Uncertain Significance	20.6 [27.45] mg/dL	1	3.98E-06	rs933777198
2:21009469:T:G	LDL-C	APOB	UKBB	c.7399A>C (p.Lys2467Gln)	missense_variant	Uncertain Significance	50.99 [30.46] mg/dL	1	3.98E-06	rs1440285761
2:21009627:T:A	LDL-C	APOB	UKBB	c.7241A>T (p.Glu2414Val)	missense_variant	Uncertain Significance	17.04 [30.47] mg/dL	1	1.60E-05	rs200759464
2:21009659:C:A	LDL-C	APOB	UKBB	c.7209G>T (p.Lys2403Asn)	missense_variant	Uncertain Significance	23.35 [17.58] mg/dL	3	4.01E-06	rs777497625
2:21009993:A:G	LDL-C	APOB	FOURIER	c.6875T>C (p.Ile2292Thr)	missense_variant	Conflicting	28.54 [19.36] mg/dL	2	3.98E-05	rs145977507
2:21009997:C:T	LDL-C	APOB	FOURIER	c.6871G>A (p.Ala2291Thr)	missense_variant	Uncertain Significance	33.81 [27.44] mg/dL	1	NA	NA
2:21010296:A:G	LDL-C	APOB	UKBB	c.6572T>C (p.Leu2191Ser)	missense_variant	Uncertain Significance	25.36 [13.62] mg/dL	5	4.91E-06	rs766444813
2:21010401:A:G	LDL-C	APOB	UKBB	c.6467T>C (p.Ile2156Thr)	missense_variant	Uncertain Significance	64.67 [17.58] mg/dL	3	NA	rs1232529396
2:21010614:C:T	LDL-C	APOB	UKBB	c.6254G>A (p.Arg2085Gln)	missense_variant	Uncertain Significance	18.86 [30.46] mg/dL	1	7.96E-06	rs376782361
2:21010616:A:T	LDL-C	APOB	FOURIER	c.6252T>A (p.Asn2084Lys)	missense_variant	Uncertain Significance	39.25 [27.54] mg/dL	1	NA	NA
2:21010707:A:C	LDL-C	APOB	UKBB	c.6161T>G (p.Ile2054Ser)	missense_variant	Uncertain Significance	59.2 [30.41] mg/dL	1	3.98E-06	rs538245770
2:21010850:G:A	LDL-C	APOB	UKBB	c.6018C>T (p.Gly2006=)	synonymous_variant	Conflicting	35.56 [13.62] mg/dL	5	1.99E-05	rs368422207
2:21010850:G:A	LDL-C	APOB	FOURIER	c.6018C>T (p.Gly2006=)	synonymous_variant	Conflicting	30.86 [27.16] mg/dL	1	1.99E-05	rs368422207
2:21011134:T:A	LDL-C	APOB	FOURIER	c.5734A>T (p.Asn1912Tyr)	missense_variant	Uncertain Significance	26.47 [27.16] mg/dL	1	3.58E-05	rs186480094
2:21011260:T:C	LDL-C	APOB	UKBB	c.5608A>G (p.Thr1870Ala)	missense_variant	Uncertain Significance	17.41 [17.59] mg/dL	3	1.59E-05	rs375985550
2:21011274:C:G	LDL-C	APOB	UKBB	c.5594G>C (p.Ser1865Thr)	missense_variant	Uncertain Significance	19.62 [30.46] mg/dL	1	3.98E-06	rs1451325201
2:21011434:C:A	LDL-C	APOB	UKBB	c.5434G>T (p.Gly1812Trp)	missense_variant	Uncertain Significance	27.55 [30.46] mg/dL	1	1.19E-05	rs140174653
2:21011481:G:C	LDL-C	APOB	FOURIER	c.5387C>G (p.Thr1796Ser)	missense_variant	Uncertain Significance	17.98 [19.33] mg/dL	2	5.17E-05	rs529168934
2:21011803:G:A	LDL-C	APOB	FOURIER	c.5065C>T (p.Arg1689Cys)	missense_variant	Uncertain Significance	24.87 [27.55] mg/dL	1	2.39E-05	rs780820172
2:21011939:C:T	LDL-C	APOB	FOURIER	c.4929G>A (p.Ala1643=)	synonymous_variant	Conflicting	23.33 [11.14] mg/dL	6	7.21E-05	rs200623857
2:21012072:C:T	LDL-C	APOB	UKBB	c.4796G>A (p.Arg1599His)	missense_variant	Conflicting	18.54 [10.77] mg/dL	8	1.40E-04	rs746414462
2:21012073:G:A	LDL-C	APOB	UKBB	c.4795C>T (p.Arg1599Cys)	missense_variant	Uncertain Significance	35.32 [30.46] mg/dL	1	1.20E-05	rs191145848
2:21012210:C:T	LDL-C	APOB	UKBB	c.4658G>A (p.Gly1553Asp)	missense_variant	Uncertain Significance	17.15 [30.46] mg/dL	1	NA	NA
2:21012324:T:C	LDL-C	APOB	UKBB	c.4544A>G (p.Asn1515Ser)	missense_variant	Uncertain Significance	18.46 [30.46] mg/dL	1	NA	rs1572785504
2:21012502:C:T	LDL-C	APOB	UKBB	c.4366G>A (p.Asp1456Asn)	missense_variant	Uncertain Significance	21.32 [10.73] mg/dL	8	1.51E-04	rs147759262
2:21013213:C:T	LDL-C	APOB	FOURIER	c.4163G>A (p.Arg1388His)	missense_variant	Conflicting	17.85 [10.39] mg/dL	7	1.91E-03	rs13306187
2:21013234:T:C	LDL-C	APOB	UKBB	c.4142A>G (p.Asp1381Gly)	missense_variant	Uncertain Significance	51.68 [30.47] mg/dL	1	NA	rs1328748832
2:21013237:G:A	LDL-C	APOB	UKBB	c.4139C>T (p.Thr1380Ile)	missense_variant	Uncertain Significance	19.2 [30.46] mg/dL	1	3.98E-06	rs752474043
2:21013349:G:A	LDL-C	APOB	FOURIER	c.4027C>T (p.Pro1343Ser)	missense_variant	Uncertain Significance	31.41 [27.18] mg/dL	1	2.39E-05	rs374427541
2:21013379:G:C	LDL-C	APOB	UKBB	c.3997C>G (p.Arg1333Gly)	missense_variant	Uncertain Significance	18.47 [21.54] mg/dL	2	7.95E-06	rs121918383
2:21013441:A:G	LDL-C	APOB	UKBB	c.3935T>C (p.Met1312Thr)	missense_variant	Uncertain Significance	18.81 [17.61] mg/dL	3	1.99E-05	rs763989940
2:21013507:T:G	LDL-C	APOB	UKBB	c.3869A>C (p.Asn1290Thr)	missense_variant	Uncertain Significance	21.21 [21.54] mg/dL	2	3.98E-06	rs749608934
2:21014462:G:T	LDL-C	APOB	FOURIER	c.3828C>A (p.Asn1276Lys)	missense_variant	Uncertain Significance	24.74 [27.47] mg/dL	1	5.17E-05	rs199966747
2:21014495:G:C	LDL-C	APOB	UKBB	c.3795C>G (p.Asn1265Lys)	missense_variant	Uncertain Significance	24.45 [30.46] mg/dL	1	NA	rs886055590
2:21014573:C:A	LDL-C	APOB	FOURIER	c.3717G>T (p.Gln1239His)	missense_variant	Uncertain Significance	73.9 [27.64] mg/dL	1	NA	rs756559649
2:21016626:T:C	LDL-C	APOB	UKBB	c.3145A>G (p.Met1049Val)	missense_variant	Uncertain Significance	16.99 [30.46] mg/dL	1	7.95E-06	rs1470970950
2:21019732:C:T	LDL-C	APOB	UKBB	c.2990G>A (p.Gly997Glu)	missense_variant	Uncertain Significance	59.26 [30.46] mg/dL	1	NA	rs1558568864
2:21019754:C:T	LDL-C	APOB	FOURIER	c.2968G>A (p.Ala990Thr)	missense_variant	Conflicting	132.38 [27.39] mg/dL	1	4.78E-05	rs139434026
2:21019859:G:A	LDL-C	APOB	UKBB	c.2863C>T (p.Pro955Ser)	missense_variant	Conflicting	30.93 [15.26] mg/dL	4	2.11E-04	rs13306206
2:21022907:G:A	LDL-C	APOB	UKBB	c.2740C>T (p.His914Tyr)	missense_variant	Uncertain Significance	24.15 [30.47] mg/dL	1	3.58E-05	rs775976285
2:21023005:A:G	LDL-C	APOB	UKBB	c.2642T>C (p.Val881Ala)	missense_variant	Uncertain Significance	24.47 [15.23] mg/dL	4	7.96E-06	rs781511068
2:21023593:A:T	LDL-C	APOB	FOURIER	c.2536T>A (p.Leu846Met)	missense_variant	Uncertain Significance	30.82 [19.43] mg/dL	2	1.99E-05	rs189880634
2:21026793:C:T	LDL-C	APOB	FOURIER	c.2239G>A (p.Glu747Lys)	missense_variant	Uncertain Significance	64.8 [27.48] mg/dL	1	3.98E-06	rs756379920
2:21026909:T:C	LDL-C	APOB	FOURIER	c.2123A>G (p.Gln708Arg)	missense_variant	Uncertain Significance	50.71 [27.43] mg/dL	1	8.35E-05	rs371190827
2:21029968:G:A	LDL-C	APOB	FOURIER	c.1400C>T (p.Ala467Val)	missense_variant	Uncertain Significance	146.4 [27.37] mg/dL	1	NA	NA
2:21029968:G:A	LDL-C	APOB	UKBB	c.1400C>T (p.Ala467Val)	missense_variant	Uncertain Significance	19.1 [30.46] mg/dL	1	NA	NA
2:21032397:G:A	LDL-C	APOB	UKBB	c.1309C>T (p.Arg437Cys)	missense_variant	Uncertain Significance	21.4 [21.54] mg/dL	2	7.97E-06	rs776786681
2:21034831:G:A	LDL-C	APOB	UKBB	c.889C>T (p.Arg297Cys)	missense_variant	Uncertain Significance	35.61 [13.62] mg/dL	5	9.94E-05	rs766376456
2:21035683:C:T	LDL-C	APOB	UKBB	c.719G>A (p.Ser240Asn)	missense_variant	Uncertain Significance	64.06 [30.46] mg/dL	1	3.98E-06	rs1275483212
2:21037104:C:T	LDL-C	APOB	UKBB	c.689G>A (p.Gly230Asp)	missense_variant	Uncertain Significance	27.23 [21.54] mg/dL	2	7.95E-06	rs755661819
2:21037138:G:A	LDL-C	APOB	UKBB	c.655C>T (p.Arg219Cys)	missense_variant	Uncertain Significance	36.81 [13.62] mg/dL	5	3.18E-05	rs145661815
2:21037224:A:G	LDL-C	APOB	UKBB	c.569T>C (p.Phe190Ser)	missense_variant	Uncertain Significance	18.18 [7.86] mg/dL	15	7.95E-06	rs1004490491
2:21037987:T:A	LDL-C	APOB	FOURIER	c.508A>T (p.Thr170Ser)	missense_variant	Uncertain Significance	51.43 [27.38] mg/dL	1	3.98E-06	rs370493370
2:21038092:T:C	LDL-C	APOB	UKBB	c.403A>G (p.Ile135Val)	missense_variant	Conflicting	17.56 [17.59] mg/dL	3	3.98E-05	rs769296548
2:21038092:T:C	LDL-C	APOB	FOURIER	c.403A>G (p.Ile135Val)	missense_variant	Conflicting	59.23 [27.38] mg/dL	1	3.98E-05	rs769296548
2:21038095:C:A	LDL-C	APOB	FOURIER	c.400G>T (p.Ala134Ser)	missense_variant	Conflicting	24.84 [27.5] mg/dL	1	1.71E-04	rs368321279
2:21038095:C:T	LDL-C	APOB	UKBB	c.400G>A (p.Ala134Thr)	missense_variant	Uncertain Significance	39.42 [15.23] mg/dL	4	NA	rs368321279
2:21041001:G:A	LDL-C	APOB	UKBB	c.320C>T (p.Pro107Leu)	missense_variant	Uncertain Significance	31.25 [12.43] mg/dL	6	3.98E-06	rs1270615687
2:21041003:G:C	LDL-C	APOB	UKBB	c.318C>G (p.Asn106Lys)	missense_variant	Uncertain Significance	39.45 [21.54] mg/dL	2	1.59E-05	rs371662800
20:44414561:A:G	HbA1c	HNF4A	FOURIER	c.481A>G (p.Ser161Gly)	missense_variant	Uncertain Significance	0.68 [0.51] (%)	3	1.59E-05	rs779555087
20:44424117:G:A	HbA1c	HNF4A	UKBB	c.926G>A (p.Arg309His)	missense_variant	Uncertain Significance	0.54 [0.49] (%)	1	4.02E-06	rs369429452
20:44424123:G:A	HbA1c	HNF4A	UKBB	c.998G>A (p.Arg333His)	missense_variant	Conflicting	0.42 [0.49] (%)	1	4.02E-06	rs1375557127
3:38550348:C:T	QTc	SCN5A	TOPMed	c.6024G>A (p.Pro2008=)	synonymous_variant	Uncertain Significance	17.56 [22.05] ms	1	5.18E-06	rs765024596
3:38550368:C:T	QTc	SCN5A	UKBB	c.6001G>A (p.Ala2001Thr)	missense_variant	Uncertain Significance	15.65 [23.07] ms	1	3.07E-05	rs771018427
3:38550369:G:A	QTc	SCN5A	TOPMed	c.6000C>T (p.Leu2000=)	synonymous_variant	Conflicting	19.93 [12.89] ms	3	0.0005935	rs538707712
3:38550401:G:A	QTc	SCN5A	UKBB	c.5971C>T (p.Arg1991Trp)	missense_variant	Uncertain Significance	26.06 [22.75] ms	1	1.37E-05	rs371308670
3:38550409:A:C	QTc	SCN5A	TOPMed	c.5963T>G (p.Leu1988Arg)	missense_variant	Conflicting	15.51 [15.5] ms	2	2.40E-04	rs145009013
3:38550409:A:C	QTc	SCN5A	UKBB	c.5963T>G (p.Leu1988Arg)	missense_variant	Conflicting	15.19 [23.12] ms	1	2.40E-04	rs145009013
3:38550411:G:T	QTc	SCN5A	TOPMed	c.5958C>A (p.Asn1986Lys)	missense_variant	Uncertain Significance	35.49 [21.85] ms	1	8.82E-06	rs199473335
3:38550434:C:A	QTc	SCN5A	TOPMed	c.5938G>T (p.Val1980Phe)	missense_variant	Conflicting	21.35 [21.89] ms	1	1.26E-05	rs772258197
3:38550459:AGTGGAGGAG:A	QTc	SCN5A	TOPMed	c.5901_5909del (p.Ser1969_Ser1971del)	inframe_deletion	Uncertain Significance	30.63 [22.31] ms	1	4.11E-06	rs745812849
3:38550512:C:T	QTc	SCN5A	UKBB	c.5857G>A (p.Glu1953Lys)	missense_variant	Uncertain Significance	14.46 [23.08] ms	1	2.44E-05	rs397517956
3:38550522:G:A	QTc	SCN5A	UKBB	c.5847C>T (p.Tyr1949=)	synonymous_variant	Conflicting	42.45 [22.64] ms	1	4.45E-05	rs367778922
3:38550527:C:T	QTc	SCN5A	UKBB	c.5845G>A (p.Ala1949Thr)	missense_variant	Uncertain Significance	28.2 [16.31] ms	2	2.83E-05	rs199473330
3:38550527:C:T	QTc	SCN5A	TOPMed	c.5845G>A (p.Ala1949Thr)	missense_variant	Uncertain Significance	17.43 [21.85] ms	1	2.83E-05	rs199473330
3:38550541:C:T	QTc	SCN5A	UKBB	c.5831G>A (p.Arg1944Gln)	missense_variant	Conflicting	15.85 [23.11] ms	1	1.61E-05	rs767089602
3:38550569:C:T	QTc	SCN5A	TOPMed	c.5803G>A (p.Gly1935Ser)	missense_variant	Uncertain Significance	65.85 [15.72] ms	2	2.81E-05	rs199473637
3:38550602:C:T	QTc	SCN5A	TOPMed	c.5770G>A (p.Ala1924Thr)	missense_variant	Conflicting	14.31 [11.2] ms	4	6.02E-05	rs137854603
3:38550617:G:A	QTc	SCN5A	TOPMed	c.5755C>T (p.Arg1919Cys)	missense_variant	Uncertain Significance	29.43 [22.26] ms	1	1.60E-05	rs199473328
3:38550629:G:A	QTc	SCN5A	TOPMed	c.5740C>T (p.His1914Tyr)	missense_variant	Uncertain Significance	24.88 [21.87] ms	1	2.01E-05	rs762462124
3:38550634:C:T	QTc	SCN5A	TOPMed	c.5738G>A (p.Arg1913His)	missense_variant	Uncertain Significance	17.49 [21.88] ms	1	2.41E-05	rs199473327
3:38550683:G:A	QTc	SCN5A	TOPMed	c.5686C>T (p.Arg1896Trp)	missense_variant	Uncertain Significance	20.45 [9.09] ms	6	7.62E-05	rs45465995
3:38550721:G:A	QTc	SCN5A	UKBB	c.5651C>T (p.Pro1884Leu)	missense_variant	Uncertain Significance	12.11 [23.08] ms	1	6.82E-05	rs755162776
3:38550845:C:G	QTc	SCN5A	UKBB	c.5527G>C (p.Val1843Leu)	missense_variant	Uncertain Significance	29.71 [23.06] ms	1	NA	rs1559720356
3:38550917:C:T	QTc	SCN5A	TOPMed	c.5455G>A (p.Asp1819Asn)	missense_variant	Conflicting	30.64 [12.68] ms	3	2.72E-04	rs137854619
3:38550966:G:C	QTc	SCN5A	TOPMed	c.5406C>G (p.Asp1802Glu)	missense_variant	Uncertain Significance	82.33 [16.51] ms	2	NA	rs1367727373
3:38551005:G:A	QTc	SCN5A	TOPMed	c.5367C>T (p.Asp1789=)	synonymous_variant	Conflicting	11.98 [8.62] ms	7	0.0001316	rs375752426
3:38551036:G:A	QTc	SCN5A	UKBB	c.5333C>T (p.Thr1778Met)	missense_variant	Conflicting	17.94 [13.33] ms	3	3.98E-05	rs199473634
3:38551043:C:T	QTc	SCN5A	UKBB	c.5329G>A (p.Val1777Met)	missense_variant	Uncertain Significance	18.36 [9.42] ms	6	1.59E-05	rs199473314
3:38551280:C:T	QTc	SCN5A	UKBB	c.5092G>A (p.Ala1698Thr)	missense_variant	Uncertain Significance	27.28 [23.07] ms	1	1.19E-05	rs199473295
3:38551344:C:T	QTc	SCN5A	UKBB	c.5028G>A (p.Met1676Ile)	missense_variant	Uncertain Significance	24.02 [23.1] ms	1	1.99E-05	rs764782158
3:38551438:G:A	QTc	SCN5A	UKBB	c.4934C>T (p.Thr1645Met)	missense_variant	Conflicting	18.53 [16.31] ms	2	2.39E-05	rs199473288
3:38551455:C:T	QTc	SCN5A	UKBB	c.4917G>A (p.Gly1639=)	synonymous_variant	Conflicting	28.29 [23.07] ms	1	1.19E-05	rs1419998623
3:38551537:A:T	QTc	SCN5A	UKBB	c.4835T>A (p.Ile1612Asn)	missense_variant	Uncertain Significance	47.74 [16.31] ms	2	NA	rs1553693063
3:38551545:C:T	QTc	SCN5A	UKBB	c.4827G>A (p.Ser1609=)	synonymous_variant	Conflicting	13.74 [23.07] ms	1	8.00E-06	rs886058460
3:38551546:G:A	QTc	SCN5A	UKBB	c.4823C>T (p.Ser1608Leu)	missense_variant	Uncertain Significance	27.68 [23.07] ms	1	1.20E-05	rs199473622
3:38551548:G:A	QTc	SCN5A	UKBB	c.4821C>T (p.Leu1607=)	synonymous_variant	Conflicting	21.14 [13.32] ms	3	0.002553	rs45437099
3:38554344:C:T	QTc	SCN5A	UKBB	c.4745G>A (p.Arg1582His)	missense_variant	Conflicting	16.07 [16.31] ms	2	2.01E-05	rs199473621
3:38554525:C:T	QTc	SCN5A	UKBB	c.4564G>A (p.Asp1522Asn)	missense_variant	Uncertain Significance	35.41 [23.07] ms	1	4.02E-05	rs777254969
3:38555663:C:T	QTc	SCN5A	UKBB	c.4535G>A (p.Arg1512Gln)	missense_variant	Uncertain Significance	21.29 [16.31] ms	2	2.39E-05	rs368219299
3:38555664:G:A	QTc	SCN5A	TOPMed	c.4531C>T (p.Arg1511Trp)	missense_variant	Conflicting	20.97 [21.92] ms	1	5.57E-05	rs137854602
3:38560221:C:T	QTc	SCN5A	UKBB	c.4171G>A (p.Gly1391Arg)	missense_variant	Uncertain Significance	18.3 [23.07] ms	1	3.60E-05	rs780405533
3:38560335:C:T	QTc	SCN5A	UKBB	c.4057G>A (p.Val1353Met)	missense_variant	Conflicting	28.18 [23.08] ms	1	2.78E-05	rs199473233
3:38560335:C:T	QTc	SCN5A	TOPMed	c.4057G>A (p.Val1353Met)	missense_variant	Conflicting	29.66 [21.89] ms	1	2.78E-05	rs199473233
3:38562471:G:T	QTc	SCN5A	UKBB	c.3904C>A (p.Arg1302=)	synonymous_variant	Conflicting	16.3 [23.07] ms	1	2.82E-05	rs200334972
3:38566522:C:T	QTc	SCN5A	TOPMed	c.3724G>A (p.Asp1242Asn)	missense_variant	Conflicting	29.58 [9.83] ms	5	1.43E-04	rs199473599
3:38566531:C:G	QTc	SCN5A	UKBB	c.3718G>C (p.Glu1240Gln)	missense_variant	Uncertain Significance	52.61 [11.56] ms	4	3.98E-05	rs199473211
3:38575443:G:A	QTc	SCN5A	UKBB	c.3520C>T (p.Arg1174Trp)	missense_variant	Uncertain Significance	15.9 [23.07] ms	1	3.08E-05	rs367906630
3:38576713:C:G	QTc	SCN5A	UKBB	c.3459G>C (p.Gln1153His)	missense_variant	Uncertain Significance	22.82 [16.35] ms	2	5.47E-05	rs776705132
3:38576733:T:C	QTc	SCN5A	UKBB	c.3439A>G (p.Thr1147Ala)	missense_variant	Uncertain Significance	36.29 [23.07] ms	1	NA	rs794728930
3:38576780:G:A	QTc	SCN5A	TOPMed	c.3392C>T (p.Thr1131Ile)	missense_variant	Uncertain Significance	22.15 [12.8] ms	3	2.51E-05	rs199473197
3:38579378:G:A	QTc	SCN5A	UKBB	c.3346C>T (p.Arg1116Trp)	missense_variant	Uncertain Significance	29.87 [23.07] ms	1	2.11E-05	rs199473196
3:38579406:G:A	QTc	SCN5A	UKBB	c.3318C>T (p.Ala1106=)	synonymous_variant	Conflicting	12.24 [23.07] ms	1	2.04E-05	rs377603706
3:38579489:A:T	QTc	SCN5A	TOPMed	c.3235T>A (p.Ser1079Thr)	missense_variant	Uncertain Significance	36.12 [22.36] ms	1	2.07E-05	rs376183542
3:38580934:C:A	QTc	SCN5A	UKBB	c.3225G>T (p.Lys1075Asn)	missense_variant	Uncertain Significance	26.04 [13.31] ms	3	NA	rs1553699582
3:38581026:C:T	QTc	SCN5A	TOPMed	c.3133G>A (p.Val1045Met)	missense_variant	Uncertain Significance	16.9 [22.34] ms	1	2.41E-05	rs527480102
3:38581063:C:A	QTc	SCN5A	TOPMed	c.3096G>T (p.Glu1032Asp)	missense_variant	Uncertain Significance	56.64 [22.33] ms	1	4.02E-06	rs376815707
3:38581065:C:T	QTc	SCN5A	UKBB	c.3094G>A (p.Glu1032Lys)	missense_variant	Conflicting	30.19 [23.08] ms	1	4.43E-05	rs369565476
3:38581127:G:A	QTc	SCN5A	UKBB	c.3032C>T (p.Pro1011Leu)	missense_variant	Uncertain Significance	15.02 [16.31] ms	2	3.27E-05	rs369249772
3:38581236:G:A	QTc	SCN5A	UKBB	c.2923C>T (p.Arg975Trp)	missense_variant	Uncertain Significance	42.41 [23.06] ms	1	3.31E-05	rs41311135
3:38581284:G:A	QTc	SCN5A	TOPMed	c.2875C>T (p.Leu959Phe)	missense_variant	Uncertain Significance	45.52 [21.88] ms	1	NA	rs1329499714
3:38581340:C:T	QTc	SCN5A	TOPMed	c.2819G>A (p.Ser940Asn)	missense_variant	Uncertain Significance	47.27 [21.86] ms	1	4.05E-06	rs879123756
3:38585881:G:A	QTc	SCN5A	UKBB	c.2597C>T (p.Ser866Leu)	missense_variant	Uncertain Significance	12.86 [16.33] ms	2	1.19E-05	rs755194086
3:38585936:T:A	QTc	SCN5A	TOPMed	c.2542A>T (p.Ile848Phe)	missense_variant	Uncertain Significance	17.1 [15.46] ms	2	3.98E-06	rs199473166
3:38587422:G:A	QTc	SCN5A	UKBB	c.2414C>T (p.Ser805Leu)	missense_variant	Uncertain Significance	28.04 [16.31] ms	2	8.05E-06	rs767947088
3:38587446:C:T	QTc	SCN5A	UKBB	c.2390G>A (p.Gly797Asp)	missense_variant	Uncertain Significance	23.95 [23.04] ms	1	NA	NA
3:38597734:T:G	QTc	SCN5A	TOPMed	c.2257A>C (p.Asn753His)	missense_variant	Uncertain Significance	26.35 [21.92] ms	1	NA	NA
3:38597944:A:C	QTc	SCN5A	TOPMed	c.2047T>G (p.Cys683Gly)	missense_variant	Uncertain Significance	23.27 [21.86] ms	1	NA	rs199473144
3:38598948:C:T	QTc	SCN5A	UKBB	c.1993G>A (p.Ala665Thr)	missense_variant	Uncertain Significance	46.39 [23.07] ms	1	6.43E-05	rs756474485
3:38598965:C:T	QTc	SCN5A	TOPMed	c.1976G>A (p.Arg659Gln)	missense_variant	Uncertain Significance	35.86 [15.73] ms	2	1.21E-05	rs374908012
3:38598998:G:A	QTc	SCN5A	TOPMed	c.1943C>T (p.Pro648Leu)	missense_variant	Uncertain Significance	20.35 [7.84] ms	8	4.03E-05	rs45609733
3:38599027:G:A	QTc	SCN5A	TOPMed	c.1914C>T (p.Gly638=)	synonymous_variant	Conflicting	32.85 [12.73] ms	3	3.24E-05	rs764488677
3:38603722:G:A	QTc	SCN5A	TOPMed	c.1880C>T (p.Pro627Leu)	missense_variant	Uncertain Significance	61.36 [22.3] ms	1	1.70E-05	rs778522112
3:38603743:C:T	QTc	SCN5A	UKBB	c.1859G>A (p.Arg620His)	missense_variant	Uncertain Significance	15.44 [23.07] ms	1	3.14E-05	rs746504626
3:38603826:G:C	QTc	SCN5A	TOPMed	c.1776C>G (p.Asn592Lys)	missense_variant	Uncertain Significance	29.54 [21.89] ms	1	3.23E-05	rs199473130
3:38603852:C:G	QTc	SCN5A	TOPMed	c.1750G>C (p.Gly584Arg)	missense_variant	Uncertain Significance	33.78 [15.78] ms	2	2.82E-05	rs763240431
3:38603868:G:A	QTc	SCN5A	TOPMed	c.1734C>T (p.Pro578=)	synonymous_variant	Conflicting	12.01 [9.95] ms	5	3.22E-05	rs200868190
3:38603890:C:A	QTc	SCN5A	TOPMed	c.1712G>T (p.Ser571Ile)	missense_variant	Uncertain Significance	21.38 [12.65] ms	3	3.21E-05	rs199473126
3:38603899:C:T	QTc	SCN5A	TOPMed	c.1703G>A (p.Arg568His)	missense_variant	Uncertain Significance	32.03 [12.95] ms	3	2.01E-05	rs199473125
3:38603939:C:T	QTc	SCN5A	UKBB	c.1663G>A (p.Glu555Lys)	missense_variant	Uncertain Significance	38.26 [23.08] ms	1	3.21E-05	rs199473123
3:38603940:G:A	QTc	SCN5A	TOPMed	c.1662C>T (p.Ser554=)	synonymous_variant	Conflicting	14.27 [22.3] ms	1	1.61E-05	rs536201762
3:38604005:G:T	QTc	SCN5A	UKBB	c.1597C>A (p.Arg533Ser)	missense_variant	Uncertain Significance	17.7 [23.11] ms	1	2.02E-05	rs775576991
3:38604064:C:T	QTc	SCN5A	TOPMed	c.1538G>A (p.Arg513His)	missense_variant	Conflicting	12.6 [15.67] ms	2	4.33E-06	rs397517951
3:38604730:A:T	QTc	SCN5A	UKBB	c.1517T>A (p.Met506Lys)	missense_variant	Uncertain Significance	16.15 [16.31] ms	2	4.03E-06	rs760531609
3:38604863:C:T	QTc	SCN5A	UKBB	c.1384G>A (p.Glu462Lys)	missense_variant	Uncertain Significance	12.25 [13.32] ms	3	2.82E-05	rs199473572
3:38606016:C:T	QTc	SCN5A	UKBB	c.1273G>A (p.Ala425Thr)	missense_variant	Conflicting	37.85 [23.06] ms	1	NA	rs761117662
3:38606772:T:C	QTc	SCN5A	UKBB	c.1037A>G (p.Glu346Gly)	missense_variant	Uncertain Significance	11.88 [9.42] ms	6	4.02E-06	rs780735882
3:38606791:G:A	QTc	SCN5A	UKBB	c.1018C>T (p.Arg340Trp)	missense_variant	Uncertain Significance	19.22 [23.06] ms	1	4.02E-06	rs199473094
3:38609776:C:T	QTc	SCN5A	UKBB	c.892G>A (p.Gly298Ser)	missense_variant	Uncertain Significance	14.67 [16.3] ms	2	2.41E-05	rs137854608
3:38609788:C:T	QTc	SCN5A	TOPMed	c.880G>A (p.Val294Met)	missense_variant	Uncertain Significance	57.78 [21.87] ms	1	2.41E-05	rs199473086
3:38613769:G:A	QTc	SCN5A	UKBB	c.677C>T (p.Ala226Val)	missense_variant	Conflicting	14.33 [23.12] ms	1	9.13E-05	rs199473561
3:38613772:C:T	QTc	SCN5A	TOPMed	c.674G>A (p.Arg225Gln)	missense_variant	Conflicting	13.5 [21.84] ms	1	1.66E-05	rs199473071
3:38620843:G:A	QTc	SCN5A	UKBB	c.611C>T (p.Ala204Val)	missense_variant	Uncertain Significance	16.29 [23.08] ms	1	NA	rs199473559
3:38620886:G:A	QTc	SCN5A	TOPMed	c.568C>T (p.Arg190Trp)	missense_variant	Uncertain Significance	14.82 [21.88] ms	1	1.65E-05	rs199473068
3:38620958:C:T	QTc	SCN5A	TOPMed	c.496G>A (p.Ala166Thr)	missense_variant	Uncertain Significance	13.21 [21.85] ms	1	2.13E-04	rs201232332
3:38620959:G:A	QTc	SCN5A	TOPMed	c.495C>T (p.Thr165=)	synonymous_variant	Conflicting	24.82 [15.51] ms	2	3.62E-05	rs62242804
3:38630335:G:A	QTc	SCN5A	TOPMed	c.368C>T (p.Ala123Val)	missense_variant	Uncertain Significance	28.65 [21.88] ms	1	7.62E-05	rs765699394
3:38630423:T:C	QTc	SCN5A	UKBB	c.280A>G (p.Ile94Val)	missense_variant	Uncertain Significance	15.96 [8.72] ms	7	1.20E-05	rs202114798
7:150946918:C:T	QTc	KCNH2	TOPMed	c.3289G>A (p.Val1097Ile)	missense_variant	Uncertain Significance	32.3 [22.11] ms	1	1.67E-05	rs199473030
7:150946956:G:A	QTc	KCNH2	TOPMed	c.3251C>T (p.Pro1084Leu)	missense_variant	Uncertain Significance	19.63 [21.91] ms	1	4.84E-05	rs762510312
7:150946960:T:C	QTc	KCNH2	UKBB	c.3247A>G (p.Thr1083Ala)	missense_variant	Uncertain Significance	30.72 [23.06] ms	1	3.64E-05	rs751559990
7:150946983:G:A	QTc	KCNH2	TOPMed	c.3224C>T (p.Pro1075Leu)	missense_variant	Uncertain Significance	23.73 [11.09] ms	4	2.00E-05	rs199473028
7:150947020:C:G	QTc	KCNH2	TOPMed	c.3187G>C (p.Val1063Leu)	missense_variant	Uncertain Significance	15.95 [12.79] ms	3	2.01E-05	rs139722868
7:150947036:A:G	QTc	KCNH2	UKBB	c.3171T>C (p.Ser1057=)	synonymous_variant	Uncertain Significance	12.02 [23.07] ms	1	NA	NA
7:150947043:C:T	QTc	KCNH2	TOPMed	c.3164G>A (p.Arg1055Gln)	missense_variant	Conflicting	19.04 [15.49] ms	2	9.01E-05	rs41307270
7:150947044:G:A	QTc	KCNH2	TOPMed	c.3163C>T (p.Arg1055Trp)	missense_variant	Uncertain Significance	40.28 [11.16] ms	4	2.87E-05	rs541259035
7:150947340:C:T	QTc	KCNH2	TOPMed	c.3140G>A (p.Arg1047His)	missense_variant	Uncertain Significance	38.04 [22.3] ms	1	2.12E-05	rs36210421
7:150947368:C:T	QTc	KCNH2	UKBB	c.3112G>A (p.Val1038Met)	missense_variant	Conflicting	28.57 [23.12] ms	1	1.24E-04	rs199473544
7:150947372:G:A	QTc	KCNH2	TOPMed	c.3108C>T (p.Gly1036=)	synonymous_variant	Conflicting	26.83 [15.48] ms	2	2.77E-05	rs373414022
7:150947379:G:GGCC	QTc	KCNH2	UKBB	c.2078_2080dup (p.Arg693_Pro694insArg)	inframe_insertion	Uncertain Significance	33.08 [23.1] ms	1	NA	rs1060499872
7:150947386:G:A	QTc	KCNH2	TOPMed	c.3094C>T (p.Arg1032Trp)	missense_variant	Uncertain Significance	14.18 [9.85] ms	5	9.55E-05	rs373394254
7:150947386:G:A	QTc	KCNH2	UKBB	c.3094C>T (p.Arg1032Trp)	missense_variant	Uncertain Significance	33.45 [23.07] ms	1	9.55E-05	rs373394254
7:150947401:G:T	QTc	KCNH2	TOPMed	c.3079C>A (p.Leu1027Ile)	missense_variant	Conflicting	41.6 [22.32] ms	1	6.69E-06	rs794728346
7:150947431:C:A	QTc	KCNH2	TOPMed	c.3049G>T (p.Ala1017Ser)	missense_variant	Uncertain Significance	17.71 [21.9] ms	1	6.40E-06	rs950543448
7:150947668:G:A	QTc	KCNH2	TOPMed	c.2903C>T (p.Pro968Leu)	missense_variant	Uncertain Significance	14.87 [12.96] ms	3	3.44E-05	rs199473017
7:150947684:G:T	QTc	KCNH2	UKBB	c.2887C>A (p.Pro963Thr)	missense_variant	Uncertain Significance	15.54 [13.32] ms	3	NA	rs199473014
7:150947710:C:T	QTc	KCNH2	UKBB	c.2861G>A (p.Arg954His)	missense_variant	Uncertain Significance	13.54 [16.31] ms	2	1.55E-05	rs772977598
7:150947710:C:T	QTc	KCNH2	TOPMed	c.2861G>A (p.Arg954His)	missense_variant	Uncertain Significance	18.49 [21.87] ms	1	1.55E-05	rs772977598
7:150947778:C:T	QTc	KCNH2	UKBB	c.2793G>A (p.Pro931=)	synonymous_variant	Uncertain Significance	21.56 [16.31] ms	2	1.50E-05	rs200976506
7:150947794:G:A	QTc	KCNH2	TOPMed	c.2777C>T (p.Pro926Leu)	missense_variant	Uncertain Significance	17.42 [21.86] ms	1	1.54E-05	rs996063617
7:150947797:C:G	QTc	KCNH2	TOPMed	c.2774G>C (p.Gly925Ala)	missense_variant	Uncertain Significance	29.83 [22.31] ms	1	7.76E-06	rs794728398
7:150947818:C:T	QTc	KCNH2	TOPMed	c.2753G>A (p.Ser918Asn)	missense_variant	Uncertain Significance	16.23 [21.92] ms	1	NA	rs1268921735
7:150947842:G:A	QTc	KCNH2	TOPMed	c.2729C>T (p.Pro910Leu)	missense_variant	Uncertain Significance	12.41 [9.06] ms	6	1.07E-04	rs199473436
7:150948452:G:T	QTc	KCNH2	TOPMed	c.2684C>A (p.Thr895Lys)	missense_variant	Uncertain Significance	65.83 [22.13] ms	1	NA	NA
7:150948471:A:C	QTc	KCNH2	TOPMed	c.2665T>G (p.Leu889Val)	missense_variant	Conflicting	20.65 [11.13] ms	4	8.46E-05	rs765427343
7:150948471:A:C	QTc	KCNH2	UKBB	c.2665T>G (p.Leu889Val)	missense_variant	Conflicting	42.46 [23.09] ms	1	8.46E-05	rs765427343
7:150948483:G:A	QTc	KCNH2	UKBB	c.2653C>T (p.Arg885Cys)	missense_variant	Uncertain Significance	38.38 [23.06] ms	1	2.24E-04	rs143512106
7:150948510:C:T	QTc	KCNH2	UKBB	c.2626G>A (p.Glu876Lys)	missense_variant	Uncertain Significance	12.05 [23.08] ms	1	NA	rs1554424688
7:150948524:G:A	QTc	KCNH2	TOPMed	c.2612C>T (p.Ser871Phe)	missense_variant	Uncertain Significance	28.58 [21.87] ms	1	3.99E-06	rs1177213407
7:150950194:C:T	QTc	KCNH2	UKBB	c.2372G>A (p.Arg791Gln)	missense_variant	Uncertain Significance	12.7 [23.1] ms	1	7.97E-06	rs770393669
7:150950195:G:A	QTc	KCNH2	UKBB	c.2371C>T (p.Arg791Trp)	missense_variant	Conflicting	36.12 [11.56] ms	4	7.57E-05	rs138498207
7:150950195:G:A	QTc	KCNH2	TOPMed	c.2371C>T (p.Arg791Trp)	missense_variant	Conflicting	17.98 [11.15] ms	4	7.57E-05	rs138498207
7:150950216:G:A	QTc	KCNH2	TOPMed	c.2350C>T (p.Arg784Trp)	missense_variant	Conflicting	40.46 [21.87] ms	1	3.98E-06	rs12720441
7:150950335:C:T	QTc	KCNH2	TOPMed	c.2231G>A (p.Arg744Gln)	missense_variant	Uncertain Significance	17.54 [21.85] ms	1	4.00E-06	rs1264176305
7:150950938:C:T	QTc	KCNH2	UKBB	c.2128G>A (p.Gly710Ser)	missense_variant	Uncertain Significance	13.82 [23.07] ms	1	NA	rs1584851956
7:150950974:C:T	QTc	KCNH2	UKBB	c.2092G>A (p.Glu698Lys)	missense_variant	Uncertain Significance	23.12 [11.53] ms	4	7.96E-06	rs753966347
7:150951013:G:A	QTc	KCNH2	TOPMed	c.2053C>T (p.Arg685Cys)	missense_variant	Conflicting	11.96 [12.82] ms	3	7.96E-06	rs778135438
7:150951732:A:G	QTc	KCNH2	UKBB	c.1661T>C (p.Met554Thr)	missense_variant	Uncertain Significance	39.85 [23.06] ms	1	NA	rs1584854609
7:150951758:G:A	QTc	KCNH2	UKBB	c.1635C>T (p.Tyr545=)	synonymous_variant	Conflicting	40.48 [23.11] ms	1	0.0001801	rs200692436
7:150952556:C:T	QTc	KCNH2	UKBB	c.1426G>A (p.Val476Ile)	missense_variant	Uncertain Significance	15.94 [16.32] ms	2	7.95E-06	rs199472908
7:150952792:C:T	QTc	KCNH2	UKBB	c.1190G>A (p.Arg397His)	missense_variant	Uncertain Significance	13.73 [10.32] ms	5	1.59E-05	rs368817970
7:150957366:C:T	QTc	KCNH2	TOPMed	c.1053G>A (p.Ser351=)	synonymous_variant	Uncertain Significance	27.45 [21.88] ms	1	8.07E-06	rs766203252
7:150957485:G:A	QTc	KCNH2	UKBB	c.934C>T (p.Arg312Cys)	missense_variant	Conflicting	17.06 [16.33] ms	2	9.99E-05	rs199472885
7:150957485:G:A	QTc	KCNH2	TOPMed	c.934C>T (p.Arg312Cys)	missense_variant	Conflicting	15.74 [15.52] ms	2	9.99E-05	rs199472885
7:150958103:A:G	QTc	KCNH2	UKBB	c.872T>C (p.Met291Thr)	missense_variant	Uncertain Significance	22.85 [16.31] ms	2	NA	rs199472881
7:150958110:C:T	QTc	KCNH2	UKBB	c.865G>A (p.Glu289Lys)	missense_variant	Uncertain Significance	11.9 [5.96] ms	15	2.55E-04	rs199472880
7:150958122:C:T	QTc	KCNH2	UKBB	c.853G>A (p.Ala285Thr)	missense_variant	Uncertain Significance	35.33 [23.07] ms	1	NA	rs864622366
7:150958251:G:A	QTc	KCNH2	UKBB	c.724C>T (p.Arg242Cys)	missense_variant	Uncertain Significance	16.96 [23.06] ms	1	1.79E-05	rs199472872
7:150958280:C:A	QTc	KCNH2	TOPMed	c.695G>T (p.Arg232Leu)	missense_variant	Uncertain Significance	25.83 [21.87] ms	1	NA	rs886039160
7:150958292:G:A	QTc	KCNH2	TOPMed	c.683C>T (p.Ala228Val)	missense_variant	Uncertain Significance	15.47 [22.31] ms	1	NA	rs1184559298
7:150958293:C:G	QTc	KCNH2	TOPMed	c.682G>C (p.Ala228Pro)	missense_variant	Uncertain Significance	71.1 [22.32] ms	1	NA	rs989191027
7:150958449:G:A	QTc	KCNH2	UKBB	c.526C>T (p.Arg176Trp)	missense_variant	Conflicting	15.42 [5.04] ms	21	3.24E-04	rs36210422
7:150958449:G:A	QTc	KCNH2	TOPMed	c.526C>T (p.Arg176Trp)	missense_variant	Conflicting	23.31 [4.91] ms	20	3.24E-04	rs36210422
7:150958484:C:T	QTc	KCNH2	UKBB	c.491G>A (p.Arg164His)	missense_variant	Uncertain Significance	13.18 [10.32] ms	5	NA	rs199472866
7:150958484:C:T	QTc	KCNH2	TOPMed	c.491G>A (p.Arg164His)	missense_variant	Uncertain Significance	34.03 [21.86] ms	1	NA	rs199472866
7:150959593:G:C	QTc	KCNH2	UKBB	c.451C>G (p.Pro151Ala)	missense_variant	Uncertain Significance	20.7 [23.07] ms	1	NA	rs1060500674
7:150959598:C:G	QTc	KCNH2	UKBB	c.446G>C (p.Gly149Ala)	missense_variant	Uncertain Significance	13.99 [16.3] ms	2	2.79E-05	rs199472865
7:150959601:C:T	QTc	KCNH2	TOPMed	c.443G>A (p.Arg148Gln)	missense_variant	Uncertain Significance	12.99 [11.13] ms	4	2.39E-05	rs374912424
7:150959613:T:A	QTc	KCNH2	TOPMed	c.431A>T (p.Asp144Val)	missense_variant	Conflicting	23.13 [11.13] ms	4	3.19E-05	rs146284716
7:150959702:G:A	QTc	KCNH2	TOPMed	c.342C>T (p.Pro114=)	synonymous_variant	Conflicting	28.94 [22.27] ms	1	0.0001591	rs532959204
7:150974830:G:T	QTc	KCNH2	TOPMed	c.188C>A (p.Pro63His)	missense_variant	Conflicting	61 [22.33] ms	1	4.24E-06	rs766379103
7:44145576:G:A	HbA1c	GCK	UKBB	c.1174C>T (p.Arg392Cys)	missense_variant	Uncertain Significance	0.55 [0.28] (%)	3	NA	rs1167124132
7:44145594:G:C	HbA1c	GCK	FOURIER	c.1156C>G (p.Leu386Val)	missense_variant	Uncertain Significance	0.96 [0.89] (%)	1	NA	rs1583591700
7:44146531:G:C	HbA1c	GCK	UKBB	c.951C>G (p.His317Gln)	missense_variant	Uncertain Significance	0.78 [0.17] (%)	8	NA	rs1379908545
7:44147765:G:A	HbA1c	GCK	UKBB	c.748C>T (p.Arg250Cys)	missense_variant	Conflicting	0.71 [0.28] (%)	3	NA	rs1057524904
7:44151069:C:T	HbA1c	GCK	UKBB	c.370G>A (p.Asp124Asn)	missense_variant	Conflicting	0.6 [0.13] (%)	13	7.96E-06	rs759072800
7:44152421:G:A	HbA1c	GCK	FOURIER	c.213C>T (p.Val71=)	synonymous_variant	Conflicting	0.53 [0.89] (%)	1	0.0002387	rs143128547
7:44153322:G:A	HbA1c	GCK	FOURIER	c.187C>T (p.Arg63Cys)	missense_variant	Uncertain Significance	1.58 [0.63] (%)	2	1.59E-05	rs754479025
7:44153372:C:A	HbA1c	GCK	UKBB	c.137G>T (p.Arg46Met)	missense_variant	Uncertain Significance	0.65 [0.49] (%)	1	NA	rs1064796993
1:55043870:G:A	LDL-C	PCSK9	UKBB	c.235G>A (p.Val79Met)	missense_variant	Not In ClinVar	22.94 [30.43] mg/dL	1	1.20E-05	rs749049179
1:55043898:T:G	LDL-C	PCSK9	FOURIER	c.263T>G (p.Leu88Arg)	missense_variant	Not In ClinVar	28.61 [27.5] mg/dL	1	NA	NA
1:55046547:T:C	LDL-C	PCSK9	UKBB	c.424T>C (p.Tyr142His)	missense_variant	Not In ClinVar	39.03 [30.46] mg/dL	1	NA	NA
1:55052319:A:G	LDL-C	PCSK9	UKBB	c.565A>G (p.Ile189Val)	missense_variant	Not In ClinVar	27.58 [30.46] mg/dL	1	NA	NA
1:55052343:G:A	LDL-C	PCSK9	UKBB	c.589G>A (p.Glu197Lys)	missense_variant	Not In ClinVar	50.89 [13.61] mg/dL	5	7.96E-06	rs772114791
1:55052353:T:C	LDL-C	PCSK9	UKBB	c.599T>C (p.Val200Ala)	missense_variant	Not In ClinVar	37.22 [21.54] mg/dL	2	NA	NA
1:55052380:C:T	LDL-C	PCSK9	UKBB	c.626C>T (p.Pro209Leu)	missense_variant	Not In ClinVar	30.49 [30.47] mg/dL	1	NA	rs1570301185
1:55052658:G:C	LDL-C	PCSK9	UKBB	c.666G>C (p.Lys222Asn)	missense_variant	Not In ClinVar	36.64 [30.47] mg/dL	1	NA	NA
1:55056012:A:C	LDL-C	PCSK9	UKBB	c.819A>C (p.Lys273Asn)	missense_variant	Not In ClinVar	21.22 [30.46] mg/dL	1	NA	rs1453038620
1:55056122:T:C	LDL-C	PCSK9	UKBB	c.929T>C (p.Val310Ala)	missense_variant	Not In ClinVar	17.32 [30.46] mg/dL	1	NA	NA
1:55056153:C:A	LDL-C	PCSK9	UKBB	c.960C>A (p.Asp320Glu)	missense_variant	Not In ClinVar	45.62 [30.46] mg/dL	1	NA	rs910368517
1:55057480:G:C	LDL-C	PCSK9	UKBB	c.1146G>C (p.Gln382His)	missense_variant	Not In ClinVar	17.54 [30.46] mg/dL	1	NA	NA
1:55058083:G:A	LDL-C	PCSK9	FOURIER	c.1228G>A (p.Glu410Lys)	missense_variant	Not In ClinVar	26.14 [27.29] mg/dL	1	2.39E-05	rs746085210
1:55058570:C:A	LDL-C	PCSK9	UKBB	c.1426C>A (p.Arg476Ser)	missense_variant	Not In ClinVar	20.93 [30.46] mg/dL	1	NA	NA
1:55059501:C:G	LDL-C	PCSK9	UKBB	c.1519C>G (p.Leu507Val)	missense_variant	Not In ClinVar	44.24 [21.54] mg/dL	2	NA	NA
1:55059520:A:G	LDL-C	PCSK9	UKBB	c.1538A>G (p.Asn513Ser)	missense_variant	Not In ClinVar	73.12 [30.46] mg/dL	1	5.70E-06	rs1243707941
1:55059528:G:C	LDL-C	PCSK9	UKBB	c.1546G>C (p.Gly516Arg)	missense_variant	Not In ClinVar	28.53 [30.46] mg/dL	1	NA	NA
1:55059538:G:A	LDL-C	PCSK9	UKBB	c.1556G>A (p.Gly519Asp)	missense_variant	Not In ClinVar	28.1 [21.54] mg/dL	2	NA	rs756504747
1:55059586:G:A	LDL-C	PCSK9	FOURIER	c.1604G>A (p.Ser535Asn)	missense_variant	Not In ClinVar	93.64 [27.22] mg/dL	1	NA	NA
1:55059642:C:A	LDL-C	PCSK9	UKBB	c.1660C>A (p.Gln554Lys)	missense_variant	Not In ClinVar	50.69 [21.54] mg/dL	2	6.38E-06	rs149311926
1:55061434:C:T	LDL-C	PCSK9	UKBB	c.1741C>T (p.Pro581Ser)	missense_variant	Not In ClinVar	27.32 [30.46] mg/dL	1	NA	NA
1:55061443:C:G	LDL-C	PCSK9	UKBB	c.1750C>G (p.Gln584Glu)	missense_variant	Not In ClinVar	22.83 [30.47] mg/dL	1	NA	NA
1:55061498:A:G	LDL-C	PCSK9	UKBB	c.1805A>G (p.His602Arg)	missense_variant	Not In ClinVar	49.97 [21.53] mg/dL	2	4.30E-06	rs1012875803
1:55061528:A:G	LDL-C	PCSK9	UKBB	c.1835A>G (p.Glu612Gly)	missense_variant	Not In ClinVar	27.85 [30.46] mg/dL	1	8.76E-06	rs753062243
11:2445441:G:A	QTc	KCNQ1	TOPMed	c.343G>A (p.Glu115Lys)	missense_variant	Not In ClinVar	52.64 [22.32] ms	1	NA	rs794728553
11:2527935:A:C	QTc	KCNQ1	TOPMed	c.394A>C (p.Ile132Leu)	missense_variant	Not In ClinVar	23.53 [21.88] ms	1	7.96E-06	rs199472684
11:2527977:G:A	QTc	KCNQ1	UKBB	c.436G>A (p.Glu146Lys)	missense_variant	Not In ClinVar	12.8 [13.32] ms	3	7.96E-06	rs199472688
11:2570682:G:T	QTc	KCNQ1	UKBB	c.532G>T (p.Ala178Ser)	missense_variant	Not In ClinVar	31.67 [23.05] ms	1	NA	NA
11:2570707:G:T	QTc	KCNQ1	UKBB	c.557G>T (p.Gly186Val)	missense_variant	Not In ClinVar	59.73 [23.06] ms	1	NA	rs794728568
11:2571325:A:G	QTc	KCNQ1	TOPMed	c.605A>G (p.Asp202Gly)	missense_variant	Not In ClinVar	19.85 [21.85] ms	1	NA	rs794728569
11:2572027:T:C	QTc	KCNQ1	TOPMed	c.698T>C (p.Leu233Pro)	missense_variant	Not In ClinVar	56.26 [22.34] ms	1	4.02E-06	rs780236727
11:2572973:T:TG	QTc	KCNQ1	TOPMed	c.909dup (p.Trp304ValfsTer159)	frameshift_variant	Not In ClinVar	17.41 [22.28] ms	1	NA	rs1280436861
11:2585276:G:A	QTc	KCNQ1	UKBB	c.1097G>A (p.Arg366Gln)	missense_variant	Not In ClinVar	29.78 [23.06] ms	1	3.98E-06	rs199473410
11:2587583:G:A	QTc	KCNQ1	UKBB	c.1142G>A (p.Cys381Tyr)	missense_variant	Not In ClinVar	22.99 [23.07] ms	1	1.19E-05	rs368507376
11:2661969:A:G	QTc	KCNQ1	UKBB	c.1402A>G (p.Ser468Gly)	missense_variant	Not In ClinVar	16.43 [23.09] ms	1	7.95E-06	rs763931151
11:2662002:T:C	QTc	KCNQ1	UKBB	c.1435T>C (p.Phe479Leu)	missense_variant	Not In ClinVar	18.52 [23.07] ms	1	NA	NA
11:2662006:T:C	QTc	KCNQ1	UKBB	c.1439T>C (p.Met480Thr)	missense_variant	Not In ClinVar	31.75 [23.07] ms	1	3.98E-06	rs967396850
11:2768848:C:T	QTc	KCNQ1	TOPMed	c.1519C>T (p.Arg507Trp)	missense_variant	Not In ClinVar	16.3 [22.32] ms	1	NA	rs767882075
11:2768867:C:T	QTc	KCNQ1	UKBB	c.1538C>T (p.Thr513Ile)	missense_variant	Not In ClinVar	12.25 [23.07] ms	1	NA	NA
12:120988996:A:G	HbA1c	HNF1A	UKBB	c.490A>G (p.Thr164Ala)	missense_variant	Not In ClinVar	0.34 [0.17] (%)	8	1.59E-05	rs772597940
12:120989008:C:T	HbA1c	HNF1A	UKBB	c.502C>T (p.Arg168Cys)	missense_variant	Not In ClinVar	0.37 [0.28] (%)	3	7.96E-06	rs764434453
12:120993591:C:T	HbA1c	HNF1A	UKBB	c.598C>T (p.Arg200Trp)	missense_variant	Not In ClinVar	1.79 [0.49] (%)	1	NA	rs193922598
12:120993675:G:A	HbA1c	HNF1A	UKBB	c.682G>A (p.Glu228Lys)	missense_variant	Not In ClinVar	0.67 [0.49] (%)	1	3.98E-06	rs747416693
12:120993696:G:A	HbA1c	HNF1A	UKBB	c.703G>A (p.Glu235Lys)	missense_variant	Not In ClinVar	0.72 [0.49] (%)	1	NA	NA
12:120994174:A:G	HbA1c	HNF1A	UKBB	c.724A>G (p.Ile242Val)	missense_variant	Not In ClinVar	0.39 [0.28] (%)	3	NA	NA
12:120994231:G:A	HbA1c	HNF1A	UKBB	c.781G>A (p.Glu261Lys)	missense_variant	Not In ClinVar	0.72 [0.49] (%)	1	NA	NA
12:120994355:A:T	HbA1c	HNF1A	UKBB	c.905A>T (p.His302Leu)	missense_variant	Not In ClinVar	0.85 [0.24] (%)	4	NA	NA
12:120994363:C:A	HbA1c	HNF1A	FOURIER	c.913C>A (p.Pro305Thr)	missense_variant	Not In ClinVar	2.1 [0.89] (%)	1	NA	rs1250206737
12:120996553:G:A	HbA1c	HNF1A	UKBB	c.1120G>A (p.Gly374Arg)	missense_variant	Not In ClinVar	0.74 [0.49] (%)	1	NA	rs1288957417
12:120996601:G:A	HbA1c	HNF1A	UKBB	c.1168G>A (p.Glu390Lys)	missense_variant	Not In ClinVar	0.5 [0.49] (%)	1	NA	NA
12:120996644:T:C	HbA1c	HNF1A	UKBB	c.1211T>C (p.Ile404Thr)	missense_variant	Not In ClinVar	0.33 [0.28] (%)	3	3.98E-06	rs1204512745
12:120996647:T:C	HbA1c	HNF1A	UKBB	c.1214T>C (p.Met405Thr)	missense_variant	Not In ClinVar	0.39 [0.49] (%)	1	NA	NA
12:120996662:G:C	HbA1c	HNF1A	UKBB	c.1229G>C (p.Gly410Ala)	missense_variant	Not In ClinVar	0.46 [0.49] (%)	1	NA	rs1471388846
12:120996725:C:A	HbA1c	HNF1A	UKBB	c.1292C>A (p.Ala431Asp)	missense_variant	Not In ClinVar	0.32 [0.49] (%)	1	NA	NA
12:120997521:G:GGCA	HbA1c	HNF1A	UKBB	c.1363_1365dup (p.Ser455dup)	inframe_insertion	Not In ClinVar	0.47 [0.34] (%)	2	8.00E-06	rs762045412
12:120997548:G:A	HbA1c	HNF1A	FOURIER	c.1384G>A (p.Val462Ile)	missense_variant	Not In ClinVar	2.34 [0.89] (%)	1	2.00E-05	rs762446965
12:120997564:C:T	HbA1c	HNF1A	FOURIER	c.1400C>T (p.Pro467Leu)	missense_variant	Not In ClinVar	0.61 [0.89] (%)	1	1.60E-05	rs764483607
12:120999277:G:A	HbA1c	HNF1A	FOURIER	c.1511G>A (p.Ser504Asn)	missense_variant	Not In ClinVar	0.48 [0.89] (%)	1	NA	NA
12:120999297:C:G	HbA1c	HNF1A	UKBB	c.1531C>G (p.Gln511Glu)	missense_variant	Not In ClinVar	0.71 [0.49] (%)	1	1.99E-05	rs551484245
12:120999318:C:G	HbA1c	HNF1A	UKBB	c.1552C>G (p.Leu518Val)	missense_variant	Not In ClinVar	0.37 [0.49] (%)	1	NA	NA
12:120999582:A:C	HbA1c	HNF1A	UKBB	c.1723A>C (p.Ile575Leu)	missense_variant	Not In ClinVar	0.48 [0.34] (%)	2	NA	NA
12:120999583:T:A	HbA1c	HNF1A	UKBB	c.1724T>A (p.Ile575Asn)	missense_variant	Not In ClinVar	0.95 [0.34] (%)	2	2.06E-05	rs577273696
17:37699098:G:A	HbA1c	HNF1B	UKBB	c.1631C>T (p.Thr544Ile)	missense_variant	Not In ClinVar	0.38 [0.49] (%)	1	3.98E-06	rs185404250
17:37699123:CTG:C	HbA1c	HNF1B	UKBB	c.1604_1605del (p.Thr535ArgfsTer15)	frameshift_variant	Not In ClinVar	0.43 [0.49] (%)	1	NA	NA
17:37699173:G:T	HbA1c	HNF1B	UKBB	c.1556C>A (p.Pro519His)	missense_variant	Not In ClinVar	3.07 [0.49] (%)	1	7.95E-06	rs745416273
17:37700995:G:C	HbA1c	HNF1B	FOURIER	c.1522C>G (p.Gln508Glu)	missense_variant	Not In ClinVar	0.43 [0.89] (%)	1	NA	rs1463022786
17:37701075:G:A	HbA1c	HNF1B	UKBB	c.1442C>T (p.Pro481Leu)	missense_variant	Not In ClinVar	0.88 [0.49] (%)	1	NA	rs1471879582
17:37701078:C:T	HbA1c	HNF1B	UKBB	c.1439G>A (p.Ser480Asn)	missense_variant	Not In ClinVar	3.68 [0.49] (%)	1	NA	rs1327364359
17:37701142:T:C	HbA1c	HNF1B	UKBB	c.1375A>G (p.Ile459Val)	missense_variant	Not In ClinVar	0.49 [0.48] (%)	1	6.31E-06	rs950617131
17:37701175:G:A	HbA1c	HNF1B	UKBB	c.1342C>T (p.Leu448Phe)	missense_variant	Not In ClinVar	0.59 [0.49] (%)	1	NA	rs1407464454
17:37705021:G:C	HbA1c	HNF1B	UKBB	c.1235C>G (p.Pro412Arg)	missense_variant	Not In ClinVar	0.56 [0.49] (%)	1	NA	NA
17:37710510:C:G	HbA1c	HNF1B	FOURIER	c.1199G>C (p.Gly400Ala)	missense_variant	Not In ClinVar	0.5 [0.89] (%)	1	3.98E-06	rs1252021904
17:37710555:G:A	HbA1c	HNF1B	UKBB	c.1154C>T (p.Ser385Phe)	missense_variant	Not In ClinVar	0.44 [0.49] (%)	1	NA	NA
17:37710556:A:T	HbA1c	HNF1B	UKBB	c.1153T>A (p.Ser385Thr)	missense_variant	Not In ClinVar	0.31 [0.49] (%)	1	NA	NA
17:37710582:G:A	HbA1c	HNF1B	UKBB	c.1127C>T (p.Thr376Ile)	missense_variant	Not In ClinVar	0.73 [0.49] (%)	1	5.26E-05	rs749391290
17:37731663:A:G	HbA1c	HNF1B	FOURIER	c.977T>C (p.Leu326Pro)	missense_variant	Not In ClinVar	0.59 [0.89] (%)	1	NA	NA
17:37731674:C:G	HbA1c	HNF1B	FOURIER	c.966G>C (p.Gln322His)	missense_variant	Not In ClinVar	1.84 [0.89] (%)	1	NA	NA
17:37731675:T:G	HbA1c	HNF1B	UKBB	c.965A>C (p.Gln322Pro)	missense_variant	Not In ClinVar	0.41 [0.49] (%)	1	NA	NA
17:37731733:G:A	HbA1c	HNF1B	UKBB	c.907C>T (p.Arg303Cys)	missense_variant	Not In ClinVar	0.52 [0.49] (%)	1	NA	NA
17:37731742:A:G	HbA1c	HNF1B	UKBB	c.898T>C (p.Phe300Leu)	missense_variant	Not In ClinVar	0.69 [0.49] (%)	1	NA	NA
17:37731770:C:A	HbA1c	HNF1B	UKBB	c.870G>T (p.Leu290Phe)	missense_variant	Not In ClinVar	1.34 [0.49] (%)	1	NA	NA
17:37733580:C:A	HbA1c	HNF1B	UKBB	c.786G>T (p.Glu262Asp)	missense_variant	Not In ClinVar	0.5 [0.49] (%)	1	NA	NA
17:37733644:G:A	HbA1c	HNF1B	UKBB	c.722C>T (p.Ala241Val)	missense_variant	Not In ClinVar	0.43 [0.34] (%)	2	7.95E-06	rs773961869
17:37739491:G:A	HbA1c	HNF1B	UKBB	c.493C>T (p.Arg165Cys)	missense_variant	Not In ClinVar	0.32 [0.49] (%)	1	NA	NA
17:37739563:C:T	HbA1c	HNF1B	UKBB	c.421G>A (p.Asp141Asn)	missense_variant	Not In ClinVar	1.6 [0.49] (%)	1	NA	rs866277746
19:11100261:G:C	LDL-C	LDLR	UKBB	c.106G>C (p.Asp36His)	missense_variant	Not In ClinVar	54.01 [30.46] mg/dL	1	NA	NA
19:11100272:CA:C	LDL-C	LDLR	UKBB	c.118del (p.Ile40SerfsTer166)	frameshift_variant	Not In ClinVar	26.22 [30.46] mg/dL	1	NA	rs879254413
19:11100328:A:T	LDL-C	LDLR	UKBB	c.173A>T (p.Glu58Val)	missense_variant	Not In ClinVar	43.91 [30.46] mg/dL	1	NA	NA
19:11102747:C:G	LDL-C	LDLR	UKBB	c.274C>G (p.Gln92Glu)	missense_variant	Not In ClinVar	93.87 [30.46] mg/dL	1	3.98E-06	rs774467219
19:11102757:G:A	LDL-C	LDLR	FOURIER	c.284G>A (p.Cys95Tyr)	missense_variant	Not In ClinVar	43.42 [27.39] mg/dL	1	NA	rs879254457
19:11102758:C:A	LDL-C	LDLR	FOURIER	c.285C>A (p.Cys95Ter)	stop_gained	Not In ClinVar	66.03 [27.44] mg/dL	1	NA	rs139400379
19:11105268:G:T	LDL-C	LDLR	UKBB	c.362G>T (p.Cys121Phe)	missense_variant	Not In ClinVar	43.05 [21.54] mg/dL	2	NA	rs193922571
19:11105299:C:G	LDL-C	LDLR	UKBB	c.393C>G (p.Asp131Glu)	missense_variant	Not In ClinVar	58.29 [30.42] mg/dL	1	NA	NA
19:11105300:C:T	LDL-C	LDLR	UKBB	c.394C>T (p.Arg132Trp)	missense_variant	Not In ClinVar	46.27 [21.54] mg/dL	2	3.98E-06	rs368978979
19:11105309:T:G	LDL-C	LDLR	UKBB	c.403T>G (p.Leu135Val)	missense_variant	Not In ClinVar	57.71 [30.46] mg/dL	1	NA	NA
19:11105318:TCAGA:T	LDL-C	LDLR	FOURIER	c.414_417del (p.Asp139ArgfsTer66)	frameshift_variant	Not In ClinVar	140.27 [27.3] mg/dL	1	NA	NA
19:11105325:A:G	LDL-C	LDLR	FOURIER	c.419A>G (p.Glu140Gly)	missense_variant	Not In ClinVar	88.6 [27.26] mg/dL	1	NA	rs879254519
19:11105334:G:GC	LDL-C	LDLR	FOURIER	c.431dup (p.Val145GlyfsTer35)	frameshift_variant	Not In ClinVar	52.17 [27.49] mg/dL	1	NA	NA
19:11105337:C:T	LDL-C	LDLR	UKBB	c.431C>T (p.Pro144Leu)	missense_variant	Not In ClinVar	71.68 [30.46] mg/dL	1	NA	rs912448894
19:11105339:GTGCTCACCTGTGGTCCCGCCAGC:G	LDL-C	LDLR	UKBB	c.435_457del (p.Leu146ProfsTer26)	frameshift_variant	Not In ClinVar	24.79 [30.46] mg/dL	1	NA	NA
19:11105363:T:C	LDL-C	LDLR	UKBB	c.457T>C (p.Phe153Leu)	missense_variant	Not In ClinVar	50.58 [30.46] mg/dL	1	NA	NA
19:11105415:A:G	LDL-C	LDLR	UKBB	c.509A>G (p.Asp170Gly)	missense_variant	Not In ClinVar	94.59 [30.46] mg/dL	1	3.98E-06	rs533896621
19:11105431:T:TGGCTCGGA	LDL-C	LDLR	FOURIER	c.526_533dup (p.Asp178GlufsTer31)	frameshift_variant	Not In ClinVar	48.77 [27.49] mg/dL	1	NA	rs879254562
19:11105448:C:T	LDL-C	LDLR	UKBB	c.542C>T (p.Pro181Leu)	missense_variant	Not In ClinVar	32.57 [21.28] mg/dL	2	7.96E-06	rs557344672
19:11105448:C:T	LDL-C	LDLR	FOURIER	c.542C>T (p.Pro181Leu)	missense_variant	Not In ClinVar	74.12 [27.32] mg/dL	1	7.96E-06	rs557344672
19:11105485:C:G	LDL-C	LDLR	UKBB	c.579C>G (p.Asp193Glu)	missense_variant	Not In ClinVar	28.3 [30.46] mg/dL	1	NA	NA
19:11106593:C:A	LDL-C	LDLR	UKBB	c.723C>A (p.Phe241Leu)	missense_variant	Not In ClinVar	55.86 [21.54] mg/dL	2	NA	NA
19:11106610:A:G	LDL-C	LDLR	UKBB	c.740A>G (p.Asn247Ser)	missense_variant	Not In ClinVar	20.56 [15.22] mg/dL	4	NA	NA
19:11106612:T:G	LDL-C	LDLR	FOURIER	c.742T>G (p.Cys248Gly)	missense_variant	Not In ClinVar	52.67 [27.33] mg/dL	1	NA	rs879254662
19:11106680:C:A	LDL-C	LDLR	FOURIER	c.810C>A (p.Cys270Ter)	stop_gained	Not In ClinVar	35.81 [27.23] mg/dL	1	NA	rs773328511
19:11107395:C:A	LDL-C	LDLR	UKBB	c.821C>A (p.Thr274Lys)	missense_variant	Not In ClinVar	31.08 [17.59] mg/dL	3	1.59E-05	rs781306850
19:11107455:A:G	LDL-C	LDLR	UKBB	c.881A>G (p.Lys294Arg)	missense_variant	Not In ClinVar	20.25 [30.46] mg/dL	1	3.98E-06	rs775843217
19:11107457:G:A	LDL-C	LDLR	UKBB	c.883G>A (p.Val295Ile)	missense_variant	Not In ClinVar	20.14 [30.46] mg/dL	1	NA	NA
19:11107466:A:G	LDL-C	LDLR	UKBB	c.892A>G (p.Met298Val)	missense_variant	Not In ClinVar	23.38 [30.46] mg/dL	1	1.19E-05	rs730882092
19:11107477:C:A	LDL-C	LDLR	UKBB	c.903C>A (p.Asp301Glu)	missense_variant	Not In ClinVar	35.32 [30.46] mg/dL	1	NA	NA
19:11107493:G:C	LDL-C	LDLR	UKBB	c.919G>C (p.Asp307His)	missense_variant	Not In ClinVar	62.69 [30.47] mg/dL	1	NA	rs879254719
19:11107499:C:G	LDL-C	LDLR	UKBB	c.925C>G (p.Pro309Ala)	missense_variant	Not In ClinVar	57.57 [30.46] mg/dL	1	NA	NA
19:11107506:A:C	LDL-C	LDLR	UKBB	c.932A>C (p.Lys311Thr)	missense_variant	Not In ClinVar	42.38 [6.64] mg/dL	21	NA	rs761765254
19:11111586:A:G	LDL-C	LDLR	UKBB	c.1133A>G (p.Gln378Arg)	missense_variant	Not In ClinVar	35.72 [30.46] mg/dL	1	NA	NA
19:11113295:TTC:T	LDL-C	LDLR	UKBB	c.1206_1207del (p.Phe403HisfsTer37)	frameshift_variant	Not In ClinVar	99.76 [30.46] mg/dL	1	NA	rs879254829
19:11113315:G:C	LDL-C	LDLR	UKBB	c.1224G>C (p.Glu408Asp)	missense_variant	Not In ClinVar	23.16 [30.46] mg/dL	1	NA	rs142319510
19:11113316:G:A	LDL-C	LDLR	FOURIER	c.1225G>A (p.Val409Ile)	missense_variant	Not In ClinVar	60.4 [27.34] mg/dL	1	3.98E-06	rs1324865629
19:11113355:C:G	LDL-C	LDLR	UKBB	c.1264C>G (p.Leu422Val)	missense_variant	Not In ClinVar	47.57 [30.41] mg/dL	1	NA	NA
19:11113362:C:T	LDL-C	LDLR	UKBB	c.1271C>T (p.Pro424Leu)	missense_variant	Not In ClinVar	25.52 [17.58] mg/dL	3	NA	rs868801795
19:11113374:A:C	LDL-C	LDLR	UKBB	c.1283A>C (p.Asn428Thr)	missense_variant	Not In ClinVar	40.95 [22.68] mg/dL	2	NA	NA
19:11113409:A:G	LDL-C	LDLR	UKBB	c.1318A>G (p.Arg440Gly)	missense_variant	Not In ClinVar	62.52 [15.22] mg/dL	4	NA	rs879254861
19:11113426:C:A	LDL-C	LDLR	UKBB	c.1335C>A (p.Asp445Glu)	missense_variant	Not In ClinVar	145.35 [30.46] mg/dL	1	1.59E-05	rs749780672
19:11113557:G:T	LDL-C	LDLR	UKBB	c.1381G>T (p.Gly461Cys)	missense_variant	Not In ClinVar	85.37 [30.48] mg/dL	1	7.97E-06	rs193922568
19:11113576:C:T	LDL-C	LDLR	UKBB	c.1400C>T (p.Thr467Ile)	missense_variant	Not In ClinVar	17.47 [17.58] mg/dL	3	3.98E-06	rs754411636
19:11113625:G:T	LDL-C	LDLR	UKBB	c.1449G>T (p.Trp483Cys)	missense_variant	Not In ClinVar	30.28 [30.43] mg/dL	1	NA	rs879254907
19:11113753:C:T	LDL-C	LDLR	FOURIER	c.1577C>T (p.Pro526Leu)	missense_variant	Not In ClinVar	23.77 [27.08] mg/dL	1	NA	rs879254944
19:11113762:G:T	LDL-C	LDLR	UKBB	c.1586G>T (p.Gly529Val)	missense_variant	Not In ClinVar	196.58 [30.45] mg/dL	1	NA	NA
19:11116099:T:A	LDL-C	LDLR	FOURIER	c.1592T>A (p.Met531Lys)	missense_variant	Not In ClinVar	26.43 [19.3] mg/dL	2	1.19E-05	rs779913921
19:11116100:G:A	LDL-C	LDLR	UKBB	c.1593G>A (p.Met531Ile)	missense_variant	Not In ClinVar	79.56 [30.46] mg/dL	1	NA	NA
19:11116114:G:A	LDL-C	LDLR	UKBB	c.1607G>A (p.Trp536Ter)	stop_gained	Not In ClinVar	111.96 [30.46] mg/dL	1	NA	rs879254957
19:11116132:T:A	LDL-C	LDLR	UKBB	c.1625T>A (p.Ile542Asn)	missense_variant	Not In ClinVar	95.67 [30.46] mg/dL	1	NA	NA
19:11116139:AG:A	LDL-C	LDLR	UKBB	c.1637del (p.Gly546AlafsTer2)	frameshift_variant	Not In ClinVar	65.64 [30.38] mg/dL	1	NA	NA
19:11116193:G:T	LDL-C	LDLR	UKBB	c.1686G>T (p.Trp562Cys)	missense_variant	Not In ClinVar	177.62 [30.46] mg/dL	1	NA	NA
19:11116861:C:A	LDL-C	LDLR	UKBB	c.1708C>A (p.Leu570Ile)	missense_variant	Not In ClinVar	34.67 [13.62] mg/dL	5	NA	NA
19:11116885:G:A	LDL-C	LDLR	UKBB	c.1732G>A (p.Val578Ile)	missense_variant	Not In ClinVar	52.08 [21.54] mg/dL	2	NA	rs1301458707
19:11116891:T:A	LDL-C	LDLR	UKBB	c.1738T>A (p.Ser580Thr)	missense_variant	Not In ClinVar	39.56 [30.46] mg/dL	1	NA	NA
19:11116904:C:T	LDL-C	LDLR	UKBB	c.1751C>T (p.Ser584Phe)	missense_variant	Not In ClinVar	100.36 [30.46] mg/dL	1	3.98E-06	rs752589590
19:11116940:A:G	LDL-C	LDLR	UKBB	c.1787A>G (p.Lys596Arg)	missense_variant	Not In ClinVar	56.7 [30.46] mg/dL	1	3.98E-06	rs752496012
19:11116970:C:A	LDL-C	LDLR	UKBB	c.1817C>A (p.Ala606Asp)	missense_variant	Not In ClinVar	22.41 [6.74] mg/dL	21	1.19E-05	rs1410295777
19:11120110:GAT:G	LDL-C	LDLR	UKBB	c.1867_1868del (p.Ile623HisfsTer21)	frameshift_variant	Not In ClinVar	38.44 [30.46] mg/dL	1	NA	rs879255061
19:11120135:G:C	LDL-C	LDLR	UKBB	c.1889G>C (p.Ser630Thr)	missense_variant	Not In ClinVar	50.52 [30.46] mg/dL	1	NA	NA
19:11120143:C:A	LDL-C	LDLR	UKBB	c.1897C>A (p.Arg633Ser)	missense_variant	Not In ClinVar	86.8 [30.46] mg/dL	1	NA	NA
19:11120221:AC:A	LDL-C	LDLR	FOURIER	c.1978del (p.Gln660SerfsTer5)	frameshift_variant	Not In ClinVar	50.93 [27.11] mg/dL	1	NA	NA
19:11120408:G:C	LDL-C	LDLR	UKBB	c.2026G>C (p.Gly676Arg)	missense_variant	Not In ClinVar	49.65 [30.47] mg/dL	1	3.99E-06	rs745753810
19:11120501:G:C	LDL-C	LDLR	FOURIER	c.2119G>C (p.Asp707His)	missense_variant	Not In ClinVar	54.08 [27.3] mg/dL	1	NA	NA
19:11120505:T:G	LDL-C	LDLR	UKBB	c.2123T>G (p.Met708Arg)	missense_variant	Not In ClinVar	31.98 [30.46] mg/dL	1	3.99E-06	rs373839317
19:11120520:C:T	LDL-C	LDLR	UKBB	c.2138C>T (p.Thr713Ile)	missense_variant	Not In ClinVar	39.05 [30.46] mg/dL	1	NA	rs1218776502
19:11123200:G:A	LDL-C	LDLR	UKBB	c.2167G>A (p.Glu723Lys)	missense_variant	Not In ClinVar	40.76 [30.46] mg/dL	1	NA	NA
19:11123201:A:G	LDL-C	LDLR	UKBB	c.2168A>G (p.Glu723Gly)	missense_variant	Not In ClinVar	23.51 [30.46] mg/dL	1	3.98E-06	rs1313468251
19:11123266:C:T	LDL-C	LDLR	UKBB	c.2233C>T (p.Pro745Ser)	missense_variant	Not In ClinVar	90.07 [30.46] mg/dL	1	NA	rs1013991512
19:11123322:G:GAT	LDL-C	LDLR	FOURIER	c.2291_2292dup (p.Val765Ter)	frameshift_variant	Not In ClinVar	108.93 [27.47] mg/dL	1	NA	NA
19:11128027:C:CA	LDL-C	LDLR	UKBB	c.2332dup (p.Arg778LysfsTer4)	frameshift_variant	Not In ClinVar	30.43 [30.46] mg/dL	1	NA	NA
19:11128051:T:G	LDL-C	LDLR	UKBB	c.2355T>G (p.Ser785Arg)	missense_variant	Not In ClinVar	45.68 [20.88] mg/dL	2	NA	rs756895842
19:11128062:C:A	LDL-C	LDLR	UKBB	c.2366C>A (p.Ala789Asp)	missense_variant	Not In ClinVar	34.93 [30.46] mg/dL	1	NA	rs1286799492
19:11129582:G:A	LDL-C	LDLR	UKBB	c.2459G>A (p.Ser820Asn)	missense_variant	Not In ClinVar	27.08 [30.46] mg/dL	1	NA	NA
19:11129627:A:C	LDL-C	LDLR	UKBB	c.2504A>C (p.Glu835Ala)	missense_variant	Not In ClinVar	29.16 [30.47] mg/dL	1	3.98E-06	rs760910475
19:11129660:G:A	LDL-C	LDLR	UKBB	c.2537G>A (p.Ser846Asn)	missense_variant	Not In ClinVar	53.63 [30.46] mg/dL	1	NA	rs1275820356
2:21004294:T:C	LDL-C	APOB	UKBB	c.12062A>G (p.Lys4021Arg)	missense_variant	Not In ClinVar	46.5 [30.46] mg/dL	1	NA	NA
2:21004345:G:A	LDL-C	APOB	UKBB	c.12011C>T (p.Pro4004Leu)	missense_variant	Not In ClinVar	20.18 [21.54] mg/dL	2	NA	NA
2:21004411:G:T	LDL-C	APOB	UKBB	c.11945C>A (p.Ala3982Glu)	missense_variant	Not In ClinVar	46.6 [30.46] mg/dL	1	NA	NA
2:21004451:C:T	LDL-C	APOB	FOURIER	c.11905G>A (p.Glu3969Lys)	missense_variant	Not In ClinVar	41.76 [27.4] mg/dL	1	3.98E-06	rs1466304592
2:21004561:T:G	LDL-C	APOB	UKBB	c.11903A>C (p.Gln3968Pro)	missense_variant	Not In ClinVar	27.31 [30.46] mg/dL	1	NA	NA
2:21005104:G:C	LDL-C	APOB	UKBB	c.11764C>G (p.Gln3922Glu)	missense_variant	Not In ClinVar	62.15 [30.46] mg/dL	1	3.98E-06	rs778476070
2:21005154:T:C	LDL-C	APOB	UKBB	c.11714A>G (p.Lys3905Arg)	missense_variant	Not In ClinVar	54.34 [30.46] mg/dL	1	NA	NA
2:21005530:C:A	LDL-C	APOB	UKBB	c.11338G>T (p.Ala3780Ser)	missense_variant	Not In ClinVar	33.07 [30.46] mg/dL	1	1.20E-05	rs781430883
2:21005532:AATG:A	LDL-C	APOB	UKBB	c.11333_11335del (p.Ser3778del)	inframe_deletion	Not In ClinVar	20.27 [21.54] mg/dL	2	NA	NA
2:21005536:A:G	LDL-C	APOB	UKBB	c.11332T>C (p.Ser3778Pro)	missense_variant	Not In ClinVar	22.22 [12.4] mg/dL	6	1.20E-05	rs1487998575
2:21005541:G:A	LDL-C	APOB	FOURIER	c.11327C>T (p.Thr3776Ile)	missense_variant	Not In ClinVar	22.81 [27.44] mg/dL	1	NA	NA
2:21005596:C:T	LDL-C	APOB	UKBB	c.11272G>A (p.Val3758Ile)	missense_variant	Not In ClinVar	31.6 [30.47] mg/dL	1	7.97E-06	rs781117588
2:21005596:C:T	LDL-C	APOB	FOURIER	c.11272G>A (p.Val3758Ile)	missense_variant	Not In ClinVar	23.31 [27.46] mg/dL	1	7.97E-06	rs781117588
2:21005790:G:T	LDL-C	APOB	FOURIER	c.11078C>A (p.Thr3693Asn)	missense_variant	Not In ClinVar	40.53 [27.35] mg/dL	1	1.20E-05	rs776068398
2:21005819:G:T	LDL-C	APOB	UKBB	c.11049C>A (p.Ser3683Arg)	missense_variant	Not In ClinVar	32.07 [30.46] mg/dL	1	NA	NA
2:21005820:C:A	LDL-C	APOB	UKBB	c.11048G>T (p.Ser3683Ile)	missense_variant	Not In ClinVar	27.52 [23.63] mg/dL	2	NA	rs944488308
2:21005901:T:A	LDL-C	APOB	FOURIER	c.10967A>T (p.Lys3656Met)	missense_variant	Not In ClinVar	51 [27.45] mg/dL	1	NA	NA
2:21005956:G:A	LDL-C	APOB	UKBB	c.10912C>T (p.Arg3638Trp)	missense_variant	Not In ClinVar	24.62 [30.46] mg/dL	1	5.19E-05	rs61744151
2:21005978:C:G	LDL-C	APOB	UKBB	c.10890G>C (p.Lys3630Asn)	missense_variant	Not In ClinVar	43.07 [30.46] mg/dL	1	3.99E-06	rs768105768
2:21005991:G:A	LDL-C	APOB	UKBB	c.10877C>T (p.Thr3626Ile)	missense_variant	Not In ClinVar	31.21 [21.57] mg/dL	2	NA	NA
2:21006007:C:A	LDL-C	APOB	FOURIER	c.10861G>T (p.Ala3621Ser)	missense_variant	Not In ClinVar	20.68 [27.12] mg/dL	1	3.98E-06	rs373995960
2:21006018:C:T	LDL-C	APOB	UKBB	c.10850G>A (p.Gly3617Asp)	missense_variant	Not In ClinVar	16.82 [30.44] mg/dL	1	3.98E-06	rs139329252
2:21006070:C:A	LDL-C	APOB	UKBB	c.10798G>T (p.Val3600Phe)	missense_variant	Not In ClinVar	55.18 [21.54] mg/dL	2	7.97E-06	rs766749418
2:21006093:G:A	LDL-C	APOB	UKBB	c.10775C>T (p.Ser3592Phe)	missense_variant	Not In ClinVar	21.73 [17.58] mg/dL	3	NA	NA
2:21006165:T:C	LDL-C	APOB	UKBB	c.10703A>G (p.Lys3568Arg)	missense_variant	Not In ClinVar	69.26 [30.46] mg/dL	1	NA	NA
2:21006198:T:TGGA	LDL-C	APOB	UKBB	c.10667_10669dup (p.Leu3556dup)	inframe_insertion	Not In ClinVar	17.68 [30.46] mg/dL	1	NA	NA
2:21006208:C:T	LDL-C	APOB	UKBB	c.10660G>A (p.Ala3554Thr)	missense_variant	Not In ClinVar	33.27 [17.58] mg/dL	3	NA	NA
2:21006391:C:T	LDL-C	APOB	UKBB	c.10477G>A (p.Glu3493Lys)	missense_variant	Not In ClinVar	52.03 [9.18] mg/dL	11	3.99E-06	rs1251501652
2:21006438:A:G	LDL-C	APOB	UKBB	c.10430T>C (p.Val3477Ala)	missense_variant	Not In ClinVar	17.12 [30.48] mg/dL	1	NA	rs190114930
2:21006471:G:T	LDL-C	APOB	UKBB	c.10397C>A (p.Ser3466Tyr)	missense_variant	Not In ClinVar	38.63 [21.51] mg/dL	2	NA	NA
2:21006513:G:C	LDL-C	APOB	UKBB	c.10355C>G (p.Pro3452Arg)	missense_variant	Not In ClinVar	45.08 [30.46] mg/dL	1	3.99E-06	rs140647761
2:21006585:G:A	LDL-C	APOB	UKBB	c.10283C>T (p.Thr3428Ile)	missense_variant	Not In ClinVar	17.93 [15.23] mg/dL	4	3.98E-06	rs764056784
2:21006603:T:C	LDL-C	APOB	UKBB	c.10265A>G (p.Glu3422Gly)	missense_variant	Not In ClinVar	16.76 [30.47] mg/dL	1	3.98E-06	rs747264737
2:21006607:T:C	LDL-C	APOB	UKBB	c.10261A>G (p.Met3421Val)	missense_variant	Not In ClinVar	39.79 [30.46] mg/dL	1	3.98E-06	rs1371028457
2:21006622:A:T	LDL-C	APOB	UKBB	c.10246T>A (p.Leu3416Ile)	missense_variant	Not In ClinVar	29.28 [30.46] mg/dL	1	NA	NA
2:21006642:C:T	LDL-C	APOB	UKBB	c.10226G>A (p.Ser3409Asn)	missense_variant	Not In ClinVar	33.31 [21.54] mg/dL	2	5.57E-05	rs759254655
2:21006654:A:G	LDL-C	APOB	UKBB	c.10214T>C (p.Phe3405Ser)	missense_variant	Not In ClinVar	25.86 [30.46] mg/dL	1	1.19E-05	rs1426386080
2:21006655:A:C	LDL-C	APOB	UKBB	c.10213T>G (p.Phe3405Val)	missense_variant	Not In ClinVar	28.3 [30.39] mg/dL	1	NA	NA
2:21006675:G:A	LDL-C	APOB	UKBB	c.10193C>T (p.Ala3398Val)	missense_variant	Not In ClinVar	58.31 [21.54] mg/dL	2	NA	rs1367798781
2:21006688:T:C	LDL-C	APOB	FOURIER	c.10180A>G (p.Lys3394Glu)	missense_variant	Not In ClinVar	40.8 [27.23] mg/dL	1	NA	NA
2:21006696:C:G	LDL-C	APOB	UKBB	c.10172G>C (p.Arg3391Thr)	missense_variant	Not In ClinVar	19.24 [21.53] mg/dL	2	NA	NA
2:21006714:G:T	LDL-C	APOB	UKBB	c.10154C>A (p.Thr3385Lys)	missense_variant	Not In ClinVar	18.61 [6.99] mg/dL	19	3.99E-06	rs1259653196
2:21006754:A:C	LDL-C	APOB	UKBB	c.10114T>G (p.Ser3372Ala)	missense_variant	Not In ClinVar	17.93 [21.54] mg/dL	2	1.99E-05	rs138850232
2:21006778:C:T	LDL-C	APOB	UKBB	c.10090G>A (p.Ala3364Thr)	missense_variant	Not In ClinVar	24.34 [21.54] mg/dL	2	NA	NA
2:21006792:T:A	LDL-C	APOB	FOURIER	c.10076A>T (p.Gln3359Leu)	missense_variant	Not In ClinVar	40.79 [27.66] mg/dL	1	NA	rs1028646792
2:21006815:A:T	LDL-C	APOB	FOURIER	c.10053T>A (p.Asn3351Lys)	missense_variant	Not In ClinVar	50.02 [27.44] mg/dL	1	NA	NA
2:21007038:G:A	LDL-C	APOB	UKBB	c.9830C>T (p.Ala3277Val)	missense_variant	Not In ClinVar	19.07 [30.46] mg/dL	1	NA	rs907962079
2:21007105:C:T	LDL-C	APOB	UKBB	c.9763G>A (p.Val3255Ile)	missense_variant	Not In ClinVar	20.11 [15.16] mg/dL	4	NA	NA
2:21007119:C:T	LDL-C	APOB	UKBB	c.9749G>A (p.Gly3250Glu)	missense_variant	Not In ClinVar	20.51 [30.46] mg/dL	1	NA	NA
2:21007152:T:G	LDL-C	APOB	UKBB	c.9716A>C (p.His3239Pro)	missense_variant	Not In ClinVar	120.7 [30.46] mg/dL	1	NA	NA
2:21007175:A:C	LDL-C	APOB	UKBB	c.9693T>G (p.Asp3231Glu)	missense_variant	Not In ClinVar	126.06 [30.46] mg/dL	1	NA	NA
2:21007200:T:C	LDL-C	APOB	UKBB	c.9668A>G (p.Tyr3223Cys)	missense_variant	Not In ClinVar	27.49 [30.52] mg/dL	1	NA	NA
2:21007290:A:C	LDL-C	APOB	UKBB	c.9578T>G (p.Leu3193Arg)	missense_variant	Not In ClinVar	26.03 [30.46] mg/dL	1	NA	NA
2:21007308:G:T	LDL-C	APOB	UKBB	c.9560C>A (p.Thr3187Lys)	missense_variant	Not In ClinVar	88 [30.46] mg/dL	1	NA	NA
2:21007323:T:C	LDL-C	APOB	FOURIER	c.9545A>G (p.His3182Arg)	missense_variant	Not In ClinVar	18.4 [27.09] mg/dL	1	NA	rs1201059427
2:21007345:C:G	LDL-C	APOB	UKBB	c.9523G>C (p.Ala3175Pro)	missense_variant	Not In ClinVar	46.04 [30.46] mg/dL	1	1.59E-05	rs200584734
2:21007368:T:G	LDL-C	APOB	UKBB	c.9500A>C (p.Gln3167Pro)	missense_variant	Not In ClinVar	19.31 [30.46] mg/dL	1	3.98E-06	rs765018719
2:21007374:G:C	LDL-C	APOB	UKBB	c.9494C>G (p.Thr3165Arg)	missense_variant	Not In ClinVar	45.33 [30.46] mg/dL	1	NA	NA
2:21007380:T:G	LDL-C	APOB	UKBB	c.9488A>C (p.Lys3163Thr)	missense_variant	Not In ClinVar	21.88 [21.54] mg/dL	2	1.99E-05	rs777931926
2:21007416:G:C	LDL-C	APOB	UKBB	c.9452C>G (p.Ser3151Cys)	missense_variant	Not In ClinVar	31.71 [30.46] mg/dL	1	7.97E-06	rs560928668
2:21007423:C:G	LDL-C	APOB	UKBB	c.9445G>C (p.Asp3149His)	missense_variant	Not In ClinVar	31.73 [21.54] mg/dL	2	NA	NA
2:21007438:T:A	LDL-C	APOB	UKBB	c.9430A>T (p.Thr3144Ser)	missense_variant	Not In ClinVar	27.2 [22.69] mg/dL	2	NA	NA
2:21007488:T:A	LDL-C	APOB	UKBB	c.9380A>T (p.Asn3127Ile)	missense_variant	Not In ClinVar	18.76 [17.57] mg/dL	3	NA	NA
2:21007521:C:T	LDL-C	APOB	UKBB	c.9347G>A (p.Gly3116Glu)	missense_variant	Not In ClinVar	44.89 [30.46] mg/dL	1	NA	rs866364156
2:21007575:T:C	LDL-C	APOB	UKBB	c.9293A>G (p.Tyr3098Cys)	missense_variant	Not In ClinVar	33.08 [21.54] mg/dL	2	3.98E-06	rs375936466
2:21007581:T:C	LDL-C	APOB	UKBB	c.9287A>G (p.Tyr3096Cys)	missense_variant	Not In ClinVar	29.34 [10.77] mg/dL	8	7.97E-06	rs1267070362
2:21007656:A:T	LDL-C	APOB	UKBB	c.9212T>A (p.Leu3071Gln)	missense_variant	Not In ClinVar	22.6 [30.46] mg/dL	1	NA	NA
2:21007696:C:T	LDL-C	APOB	UKBB	c.9172G>A (p.Val3058Ile)	missense_variant	Not In ClinVar	26.8 [30.46] mg/dL	1	NA	NA
2:21007762:A:G	LDL-C	APOB	UKBB	c.9106T>C (p.Ser3036Pro)	missense_variant	Not In ClinVar	63.96 [30.46] mg/dL	1	NA	NA
2:21007808:C:A	LDL-C	APOB	FOURIER	c.9060G>T (p.Arg3020Ser)	missense_variant	Not In ClinVar	26.29 [27.29] mg/dL	1	NA	NA
2:21007846:C:T	LDL-C	APOB	UKBB	c.9022G>A (p.Ala3008Thr)	missense_variant	Not In ClinVar	32.67 [21.54] mg/dL	2	3.98E-06	rs760938593
2:21007847:C:T	LDL-C	APOB	FOURIER	c.9021G>A (p.Met3007Ile)	missense_variant	Not In ClinVar	26.85 [27.3] mg/dL	1	3.98E-06	rs1245621355
2:21007864:G:C	LDL-C	APOB	UKBB	c.9004C>G (p.Leu3002Val)	missense_variant	Not In ClinVar	46.59 [30.46] mg/dL	1	NA	NA
2:21007915:T:C	LDL-C	APOB	UKBB	c.8953A>G (p.Lys2985Glu)	missense_variant	Not In ClinVar	47.54 [21.54] mg/dL	2	3.98E-06	rs1179639939
2:21007972:T:C	LDL-C	APOB	UKBB	c.8896A>G (p.Lys2966Glu)	missense_variant	Not In ClinVar	20.05 [30.46] mg/dL	1	NA	NA
2:21007986:T:A	LDL-C	APOB	UKBB	c.8882A>T (p.Asn2961Ile)	missense_variant	Not In ClinVar	26.59 [13.9] mg/dL	5	4.38E-05	rs142756262
2:21008091:T:C	LDL-C	APOB	UKBB	c.8777A>G (p.Lys2926Arg)	missense_variant	Not In ClinVar	25.25 [21.55] mg/dL	2	NA	NA
2:21008110:C:T	LDL-C	APOB	UKBB	c.8758G>A (p.Ala2920Thr)	missense_variant	Not In ClinVar	41.51 [30.46] mg/dL	1	NA	NA
2:21008202:T:C	LDL-C	APOB	FOURIER	c.8666A>G (p.Tyr2889Cys)	missense_variant	Not In ClinVar	41.82 [27.32] mg/dL	1	NA	NA
2:21008309:T:A	LDL-C	APOB	UKBB	c.8559A>T (p.Lys2853Asn)	missense_variant	Not In ClinVar	19.62 [30.46] mg/dL	1	NA	NA
2:21008329:C:T	LDL-C	APOB	UKBB	c.8539G>A (p.Gly2847Arg)	missense_variant	Not In ClinVar	29.29 [30.46] mg/dL	1	NA	NA
2:21008341:T:G	LDL-C	APOB	UKBB	c.8527A>C (p.Met2843Leu)	missense_variant	Not In ClinVar	34.41 [30.47] mg/dL	1	3.98E-06	rs1294025132
2:21008354:C:G	LDL-C	APOB	UKBB	c.8514G>C (p.Glu2838Asp)	missense_variant	Not In ClinVar	21.2 [21.53] mg/dL	2	NA	NA
2:21008407:G:A	LDL-C	APOB	UKBB	c.8461C>T (p.Pro2821Ser)	missense_variant	Not In ClinVar	34.75 [30.46] mg/dL	1	NA	NA
2:21008418:G:A	LDL-C	APOB	UKBB	c.8450C>T (p.Pro2817Leu)	missense_variant	Not In ClinVar	17.86 [30.46] mg/dL	1	3.98E-06	rs780434933
2:21008463:T:A	LDL-C	APOB	UKBB	c.8405A>T (p.Glu2802Val)	missense_variant	Not In ClinVar	70.96 [30.46] mg/dL	1	NA	NA
2:21008524:T:G	LDL-C	APOB	UKBB	c.8344A>C (p.Thr2782Pro)	missense_variant	Not In ClinVar	31.01 [30.46] mg/dL	1	NA	NA
2:21008602:C:A	LDL-C	APOB	UKBB	c.8266G>T (p.Gly2756Cys)	missense_variant	Not In ClinVar	34.22 [29.79] mg/dL	1	NA	NA
2:21008619:A:G	LDL-C	APOB	UKBB	c.8249T>C (p.Ile2750Thr)	missense_variant	Not In ClinVar	37.64 [30.46] mg/dL	1	NA	NA
2:21008622:G:T	LDL-C	APOB	UKBB	c.8246C>A (p.Thr2749Lys)	missense_variant	Not In ClinVar	18.8 [30.46] mg/dL	1	NA	NA
2:21008623:T:C	LDL-C	APOB	UKBB	c.8245A>G (p.Thr2749Ala)	missense_variant	Not In ClinVar	17.97 [11.78] mg/dL	7	3.99E-06	rs1429563329
2:21008626:G:T	LDL-C	APOB	UKBB	c.8242C>A (p.His2748Asn)	missense_variant	Not In ClinVar	124.35 [30.47] mg/dL	1	NA	NA
2:21008641:G:C	LDL-C	APOB	UKBB	c.8227C>G (p.Leu2743Val)	missense_variant	Not In ClinVar	36.01 [13.62] mg/dL	5	7.97E-06	rs777302365
2:21008725:C:T	LDL-C	APOB	UKBB	c.8143G>A (p.Glu2715Lys)	missense_variant	Not In ClinVar	29.52 [17.58] mg/dL	3	3.98E-06	rs779154032
2:21008823:C:G	LDL-C	APOB	UKBB	c.8045G>C (p.Ser2682Thr)	missense_variant	Not In ClinVar	21.7 [17.58] mg/dL	3	3.98E-06	rs375053331
2:21009004:T:C	LDL-C	APOB	UKBB	c.7864A>G (p.Thr2622Ala)	missense_variant	Not In ClinVar	25.12 [30.28] mg/dL	1	NA	NA
2:21009009:G:C	LDL-C	APOB	UKBB	c.7859C>G (p.Pro2620Arg)	missense_variant	Not In ClinVar	51.31 [30.46] mg/dL	1	NA	NA
2:21009013:C:T	LDL-C	APOB	UKBB	c.7855G>A (p.Val2619Ile)	missense_variant	Not In ClinVar	17.49 [21.54] mg/dL	2	NA	NA
2:21009042:T:G	LDL-C	APOB	UKBB	c.7826A>C (p.Lys2609Thr)	missense_variant	Not In ClinVar	22.2 [21.54] mg/dL	2	3.98E-06	rs1421393250
2:21009082:T:C	LDL-C	APOB	UKBB	c.7786A>G (p.Thr2596Ala)	missense_variant	Not In ClinVar	18.7 [30.46] mg/dL	1	NA	NA
2:21009089:G:C	LDL-C	APOB	UKBB	c.7779C>G (p.Ile2593Met)	missense_variant	Not In ClinVar	17.6 [30.46] mg/dL	1	3.99E-06	rs1381971004
2:21009103:C:T	LDL-C	APOB	UKBB	c.7765G>A (p.Glu2589Lys)	missense_variant	Not In ClinVar	28.31 [30.46] mg/dL	1	NA	NA
2:21009112:T:C	LDL-C	APOB	UKBB	c.7756A>G (p.Thr2586Ala)	missense_variant	Not In ClinVar	26.06 [30.46] mg/dL	1	NA	NA
2:21009117:C:A	LDL-C	APOB	UKBB	c.7751G>T (p.Gly2584Val)	missense_variant	Not In ClinVar	25.19 [30.46] mg/dL	1	7.98E-06	rs370426974
2:21009118:C:T	LDL-C	APOB	UKBB	c.7750G>A (p.Gly2584Arg)	missense_variant	Not In ClinVar	66.83 [30.46] mg/dL	1	NA	rs1558563314
2:21009129:A:G	LDL-C	APOB	UKBB	c.7739T>C (p.Leu2580Ser)	missense_variant	Not In ClinVar	28.54 [30.46] mg/dL	1	1.60E-05	rs763409720
2:21009141:C:A	LDL-C	APOB	UKBB	c.7727G>T (p.Arg2576Leu)	missense_variant	Not In ClinVar	65.56 [30.46] mg/dL	1	NA	NA
2:21009176:A:C	LDL-C	APOB	UKBB	c.7692T>G (p.Phe2564Leu)	missense_variant	Not In ClinVar	34.29 [30.46] mg/dL	1	NA	NA
2:21009198:G:A	LDL-C	APOB	UKBB	c.7670C>T (p.Ala2557Val)	missense_variant	Not In ClinVar	17.34 [30.46] mg/dL	1	NA	rs749632317
2:21009303:C:A	LDL-C	APOB	UKBB	c.7565G>T (p.Arg2522Leu)	missense_variant	Not In ClinVar	24.06 [30.46] mg/dL	1	NA	NA
2:21009357:G:A	LDL-C	APOB	UKBB	c.7511C>T (p.Ser2504Phe)	missense_variant	Not In ClinVar	27.04 [30.46] mg/dL	1	NA	NA
2:21009366:C:T	LDL-C	APOB	UKBB	c.7502G>A (p.Ser2501Asn)	missense_variant	Not In ClinVar	17.46 [30.46] mg/dL	1	1.19E-05	rs893804958
2:21009375:T:C	LDL-C	APOB	UKBB	c.7493A>G (p.Glu2498Gly)	missense_variant	Not In ClinVar	41.86 [30.46] mg/dL	1	NA	NA
2:21009395:T:G	LDL-C	APOB	UKBB	c.7473A>C (p.Leu2491Phe)	missense_variant	Not In ClinVar	28.37 [30.46] mg/dL	1	NA	NA
2:21009486:T:C	LDL-C	APOB	UKBB	c.7382A>G (p.Gln2461Arg)	missense_variant	Not In ClinVar	67.34 [30.46] mg/dL	1	NA	rs762626761
2:21009490:G:A	LDL-C	APOB	UKBB	c.7378C>T (p.Pro2460Ser)	missense_variant	Not In ClinVar	25.75 [17.59] mg/dL	3	NA	NA
2:21009496:C:G	LDL-C	APOB	FOURIER	c.7372G>C (p.Glu2458Gln)	missense_variant	Not In ClinVar	28.43 [27.16] mg/dL	1	1.99E-05	rs200783423
2:21009522:C:T	LDL-C	APOB	UKBB	c.7346G>A (p.Arg2449Lys)	missense_variant	Not In ClinVar	49.74 [21.52] mg/dL	2	NA	rs576639442
2:21009549:T:C	LDL-C	APOB	UKBB	c.7319A>G (p.Asn2440Ser)	missense_variant	Not In ClinVar	21.61 [13.61] mg/dL	5	3.99E-06	rs1458149815
2:21009636:G:A	LDL-C	APOB	UKBB	c.7232C>T (p.Thr2411Ile)	missense_variant	Not In ClinVar	19.99 [10.74] mg/dL	8	4.00E-06	rs752133513
2:21009678:A:G	LDL-C	APOB	UKBB	c.7190T>C (p.Ile2397Thr)	missense_variant	Not In ClinVar	66.24 [21.54] mg/dL	2	4.01E-06	rs766659611
2:21009682:A:T	LDL-C	APOB	UKBB	c.7186T>A (p.Phe2396Ile)	missense_variant	Not In ClinVar	41.42 [30.46] mg/dL	1	NA	NA
2:21009723:T:G	LDL-C	APOB	UKBB	c.7145A>C (p.Gln2382Pro)	missense_variant	Not In ClinVar	44.48 [30.46] mg/dL	1	NA	NA
2:21009738:A:G	LDL-C	APOB	UKBB	c.7130T>C (p.Leu2377Pro)	missense_variant	Not In ClinVar	27.35 [30.46] mg/dL	1	NA	NA
2:21009750:G:C	LDL-C	APOB	UKBB	c.7118C>G (p.Thr2373Ser)	missense_variant	Not In ClinVar	31.01 [30.46] mg/dL	1	NA	NA
2:21009767:T:G	LDL-C	APOB	UKBB	c.7101A>C (p.Gln2367His)	missense_variant	Not In ClinVar	18.15 [21.54] mg/dL	2	NA	NA
2:21009933:T:C	LDL-C	APOB	UKBB	c.6935A>G (p.Asp2312Gly)	missense_variant	Not In ClinVar	24.69 [21.54] mg/dL	2	4.78E-05	rs1421302435
2:21009954:A:G	LDL-C	APOB	UKBB	c.6914T>C (p.Ile2305Thr)	missense_variant	Not In ClinVar	32.47 [30.46] mg/dL	1	NA	NA
2:21009982:C:G	LDL-C	APOB	UKBB	c.6886G>C (p.Val2296Leu)	missense_variant	Not In ClinVar	18.93 [30.46] mg/dL	1	7.96E-06	rs150721027
2:21010005:T:G	LDL-C	APOB	UKBB	c.6863A>C (p.His2288Pro)	missense_variant	Not In ClinVar	54.89 [30.46] mg/dL	1	NA	NA
2:21010030:G:T	LDL-C	APOB	UKBB	c.6838C>A (p.His2280Asn)	missense_variant	Not In ClinVar	18.62 [30.46] mg/dL	1	NA	NA
2:21010041:A:G	LDL-C	APOB	UKBB	c.6827T>C (p.Ile2276Thr)	missense_variant	Not In ClinVar	41.96 [30.46] mg/dL	1	NA	rs1553383646
2:21010046:C:A	LDL-C	APOB	UKBB	c.6822G>T (p.Gln2274His)	missense_variant	Not In ClinVar	22.3 [30.46] mg/dL	1	NA	NA
2:21010144:C:G	LDL-C	APOB	UKBB	c.6724G>C (p.Gly2242Arg)	missense_variant	Not In ClinVar	20.41 [30.46] mg/dL	1	NA	NA
2:21010324:C:A	LDL-C	APOB	UKBB	c.6544G>T (p.Asp2182Tyr)	missense_variant	Not In ClinVar	37.45 [30.47] mg/dL	1	4.75E-06	rs1558564156
2:21010351:G:C	LDL-C	APOB	UKBB	c.6517C>G (p.Gln2173Glu)	missense_variant	Not In ClinVar	37.9 [29.25] mg/dL	1	8.71E-06	rs200370790
2:21010392:G:C	LDL-C	APOB	UKBB	c.6476C>G (p.Ala2159Gly)	missense_variant	Not In ClinVar	42.75 [21.54] mg/dL	2	NA	NA
2:21010585:C:A	LDL-C	APOB	UKBB	c.6283G>T (p.Val2095Leu)	missense_variant	Not In ClinVar	23.63 [30.46] mg/dL	1	NA	NA
2:21010632:T:C	LDL-C	APOB	UKBB	c.6236A>G (p.Glu2079Gly)	missense_variant	Not In ClinVar	64.91 [30.46] mg/dL	1	NA	NA
2:21010638:A:G	LDL-C	APOB	UKBB	c.6230T>C (p.Leu2077Ser)	missense_variant	Not In ClinVar	30.79 [21.54] mg/dL	2	NA	NA
2:21010641:G:A	LDL-C	APOB	UKBB	c.6227C>T (p.Thr2076Ile)	missense_variant	Not In ClinVar	43.27 [21.54] mg/dL	2	1.19E-05	rs371068679
2:21010689:T:C	LDL-C	APOB	UKBB	c.6179A>G (p.Tyr2060Cys)	missense_variant	Not In ClinVar	31.74 [30.46] mg/dL	1	3.98E-06	rs753938407
2:21010707:A:G	LDL-C	APOB	UKBB	c.6161T>C (p.Ile2054Thr)	missense_variant	Not In ClinVar	36.73 [21.54] mg/dL	2	NA	rs538245770
2:21010725:T:C	LDL-C	APOB	UKBB	c.6143A>G (p.Lys2048Arg)	missense_variant	Not In ClinVar	34.67 [30.46] mg/dL	1	NA	NA
2:21010737:T:C	LDL-C	APOB	FOURIER	c.6131A>G (p.Asp2044Gly)	missense_variant	Not In ClinVar	62.21 [27.65] mg/dL	1	NA	rs1558564449
2:21010758:A:G	LDL-C	APOB	FOURIER	c.6110T>C (p.Ile2037Thr)	missense_variant	Not In ClinVar	16.84 [13.66] mg/dL	4	1.99E-05	rs150068105
2:21010764:T:C	LDL-C	APOB	UKBB	c.6104A>G (p.Asn2035Ser)	missense_variant	Not In ClinVar	17.78 [30.46] mg/dL	1	NA	rs749057660
2:21010863:T:C	LDL-C	APOB	FOURIER	c.6005A>G (p.Lys2002Arg)	missense_variant	Not In ClinVar	48.38 [27.37] mg/dL	1	NA	NA
2:21010900:T:G	LDL-C	APOB	UKBB	c.5968A>C (p.Asn1990His)	missense_variant	Not In ClinVar	24.79 [21.54] mg/dL	2	NA	rs372283478
2:21010945:C:A	LDL-C	APOB	UKBB	c.5923G>T (p.Ala1975Ser)	missense_variant	Not In ClinVar	32.17 [30.46] mg/dL	1	3.98E-06	rs962782390
2:21010962:C:T	LDL-C	APOB	UKBB	c.5906G>A (p.Ser1969Asn)	missense_variant	Not In ClinVar	35.33 [21.54] mg/dL	2	NA	NA
2:21010992:C:T	LDL-C	APOB	UKBB	c.5876G>A (p.Ser1959Asn)	missense_variant	Not In ClinVar	60.36 [30.46] mg/dL	1	NA	NA
2:21010998:C:T	LDL-C	APOB	UKBB	c.5870G>A (p.Arg1957Lys)	missense_variant	Not In ClinVar	45.89 [30.46] mg/dL	1	NA	rs868467341
2:21011011:G:T	LDL-C	APOB	UKBB	c.5857C>A (p.His1953Asn)	missense_variant	Not In ClinVar	20.42 [30.46] mg/dL	1	NA	NA
2:21011037:T:A	LDL-C	APOB	UKBB	c.5831A>T (p.His1944Leu)	missense_variant	Not In ClinVar	64.91 [30.42] mg/dL	1	NA	NA
2:21011146:C:A	LDL-C	APOB	UKBB	c.5722G>T (p.Asp1908Tyr)	missense_variant	Not In ClinVar	27.84 [30.46] mg/dL	1	NA	NA
2:21011154:A:G	LDL-C	APOB	UKBB	c.5714T>C (p.Met1905Thr)	missense_variant	Not In ClinVar	53.66 [30.46] mg/dL	1	3.98E-06	rs757292609
2:21011191:T:A	LDL-C	APOB	UKBB	c.5677A>T (p.Ser1893Cys)	missense_variant	Not In ClinVar	64.92 [30.46] mg/dL	1	NA	NA
2:21011254:T:C	LDL-C	APOB	UKBB	c.5614A>G (p.Ile1872Val)	missense_variant	Not In ClinVar	51.52 [30.46] mg/dL	1	7.96E-06	rs758708880
2:21011269:G:C	LDL-C	APOB	UKBB	c.5599C>G (p.Arg1867Gly)	missense_variant	Not In ClinVar	42.23 [30.46] mg/dL	1	NA	NA
2:21011293:C:A	LDL-C	APOB	UKBB	c.5575G>T (p.Val1859Phe)	missense_variant	Not In ClinVar	34.63 [30.46] mg/dL	1	3.98E-06	rs770773955
2:21011404:G:C	LDL-C	APOB	UKBB	c.5464C>G (p.His1822Asp)	missense_variant	Not In ClinVar	27.67 [30.46] mg/dL	1	NA	NA
2:21011473:T:C	LDL-C	APOB	UKBB	c.5395A>G (p.Ser1799Gly)	missense_variant	Not In ClinVar	31.02 [30.46] mg/dL	1	NA	rs1172073539
2:21011481:G:A	LDL-C	APOB	UKBB	c.5387C>T (p.Thr1796Ile)	missense_variant	Not In ClinVar	20.19 [11.51] mg/dL	7	3.98E-06	rs529168934
2:21011614:C:T	LDL-C	APOB	FOURIER	c.5254G>A (p.Asp1752Asn)	missense_variant	Not In ClinVar	22.68 [27.56] mg/dL	1	NA	NA
2:21011640:A:G	LDL-C	APOB	UKBB	c.5228T>C (p.Met1743Thr)	missense_variant	Not In ClinVar	65.34 [30.43] mg/dL	1	NA	NA
2:21011649:T:G	LDL-C	APOB	UKBB	c.5219A>C (p.Asn1740Thr)	missense_variant	Not In ClinVar	50.76 [30.46] mg/dL	1	NA	NA
2:21011652:G:A	LDL-C	APOB	UKBB	c.5216C>T (p.Ser1739Leu)	missense_variant	Not In ClinVar	43.31 [30.46] mg/dL	1	NA	NA
2:21011694:T:C	LDL-C	APOB	UKBB	c.5174A>G (p.Asn1725Ser)	missense_variant	Not In ClinVar	22.2 [30.37] mg/dL	1	NA	NA
2:21011770:C:T	LDL-C	APOB	FOURIER	c.5098G>A (p.Asp1700Asn)	missense_variant	Not In ClinVar	81.25 [27.52] mg/dL	1	3.98E-06	rs140783923
2:21011917:C:T	LDL-C	APOB	UKBB	c.4951G>A (p.Gly1651Arg)	missense_variant	Not In ClinVar	27.63 [30.46] mg/dL	1	7.99E-06	rs748424949
2:21011925:C:T	LDL-C	APOB	UKBB	c.4943G>A (p.Gly1648Asp)	missense_variant	Not In ClinVar	45.72 [30.46] mg/dL	1	4.00E-06	rs747178150
2:21011931:C:T	LDL-C	APOB	UKBB	c.4937G>A (p.Arg1646Lys)	missense_variant	Not In ClinVar	21.54 [30.46] mg/dL	1	NA	rs1048145717
2:21011949:G:C	LDL-C	APOB	UKBB	c.4919C>G (p.Ala1640Gly)	missense_variant	Not In ClinVar	18.08 [13.62] mg/dL	5	4.01E-06	rs769028062
2:21011950:C:T	LDL-C	APOB	UKBB	c.4918G>A (p.Ala1640Thr)	missense_variant	Not In ClinVar	23.14 [15.22] mg/dL	4	4.01E-06	rs1445836748
2:21012103:T:C	LDL-C	APOB	UKBB	c.4765A>G (p.Met1589Val)	missense_variant	Not In ClinVar	27.43 [21.53] mg/dL	2	NA	rs1572785258
2:21012221:A:T	LDL-C	APOB	UKBB	c.4647T>A (p.Asp1549Glu)	missense_variant	Not In ClinVar	33.43 [30.46] mg/dL	1	NA	NA
2:21012289:G:A	LDL-C	APOB	UKBB	c.4579C>T (p.Leu1527Phe)	missense_variant	Not In ClinVar	82.66 [30.46] mg/dL	1	NA	rs1258983472
2:21012348:C:T	LDL-C	APOB	UKBB	c.4520G>A (p.Arg1507Lys)	missense_variant	Not In ClinVar	17.02 [13.62] mg/dL	5	NA	rs748251675
2:21012411:A:G	LDL-C	APOB	UKBB	c.4457T>C (p.Ile1486Thr)	missense_variant	Not In ClinVar	45.61 [30.46] mg/dL	1	NA	NA
2:21012513:A:G	LDL-C	APOB	UKBB	c.4355T>C (p.Leu1452Ser)	missense_variant	Not In ClinVar	18.06 [30.46] mg/dL	1	NA	NA
2:21012516:C:T	LDL-C	APOB	UKBB	c.4352G>A (p.Gly1451Asp)	missense_variant	Not In ClinVar	25.55 [15.23] mg/dL	4	3.98E-06	rs777471630
2:21012526:C:T	LDL-C	APOB	UKBB	c.4342G>A (p.Val1448Ile)	missense_variant	Not In ClinVar	74.54 [30.46] mg/dL	1	NA	NA
2:21012582:T:G	LDL-C	APOB	UKBB	c.4286A>C (p.Lys1429Thr)	missense_variant	Not In ClinVar	28.17 [30.46] mg/dL	1	NA	NA
2:21012636:G:A	LDL-C	APOB	UKBB	c.4232C>T (p.Thr1411Ile)	missense_variant	Not In ClinVar	21.95 [21.28] mg/dL	2	NA	NA
2:21013357:A:G	LDL-C	APOB	UKBB	c.4019T>C (p.Phe1340Ser)	missense_variant	Not In ClinVar	19.94 [30.46] mg/dL	1	3.98E-06	rs755257567
2:21013471:A:C	LDL-C	APOB	FOURIER	c.3905T>G (p.Phe1302Cys)	missense_variant	Not In ClinVar	25.98 [27.25] mg/dL	1	NA	rs979720051
2:21013475:G:A	LDL-C	APOB	FOURIER	c.3901C>T (p.Pro1301Ser)	missense_variant	Not In ClinVar	47.57 [27.28] mg/dL	1	NA	NA
2:21014513:C:G	LDL-C	APOB	UKBB	c.3777G>C (p.Lys1259Asn)	missense_variant	Not In ClinVar	30.28 [17.58] mg/dL	3	NA	NA
2:21014557:G:A	LDL-C	APOB	UKBB	c.3733C>T (p.Leu1245Phe)	missense_variant	Not In ClinVar	25.5 [30.46] mg/dL	1	NA	NA
2:21015492:A:G	LDL-C	APOB	UKBB	c.3386T>C (p.Leu1129Ser)	missense_variant	Not In ClinVar	23.14 [21.54] mg/dL	2	NA	NA
2:21015511:C:T	LDL-C	APOB	UKBB	c.3367G>A (p.Val1123Ile)	missense_variant	Not In ClinVar	26.72 [30.46] mg/dL	1	NA	NA
2:21016455:G:A	LDL-C	APOB	UKBB	c.3316C>T (p.Leu1106Phe)	missense_variant	Not In ClinVar	45.6 [30.46] mg/dL	1	7.96E-06	rs750542641
2:21016532:T:C	LDL-C	APOB	UKBB	c.3239A>G (p.Asn1080Ser)	missense_variant	Not In ClinVar	18.2 [6.36] mg/dL	23	1.59E-05	rs201825493
2:21016575:T:A	LDL-C	APOB	UKBB	c.3196A>T (p.Ile1066Phe)	missense_variant	Not In ClinVar	72.15 [30.46] mg/dL	1	NA	NA
2:21016620:A:G	LDL-C	APOB	UKBB	c.3151T>C (p.Phe1051Leu)	missense_variant	Not In ClinVar	31.36 [30.46] mg/dL	1	NA	NA
2:21019040:C:T	LDL-C	APOB	UKBB	c.3073G>A (p.Glu1025Lys)	missense_variant	Not In ClinVar	33.4 [30.46] mg/dL	1	NA	NA
2:21019045:T:A	LDL-C	APOB	UKBB	c.3068A>T (p.Gln1023Leu)	missense_variant	Not In ClinVar	42.72 [30.46] mg/dL	1	NA	NA
2:21019077:C:G	LDL-C	APOB	UKBB	c.3036G>C (p.Glu1012Asp)	missense_variant	Not In ClinVar	29.54 [30.46] mg/dL	1	NA	NA
2:21019083:C:G	LDL-C	APOB	UKBB	c.3030G>C (p.Glu1010Asp)	missense_variant	Not In ClinVar	50.32 [30.46] mg/dL	1	3.98E-06	rs764325150
2:21019106:G:C	LDL-C	APOB	UKBB	c.3007C>G (p.Leu1003Val)	missense_variant	Not In ClinVar	38.15 [30.46] mg/dL	1	NA	NA
2:21019750:G:A	LDL-C	APOB	UKBB	c.2972C>T (p.Ser991Phe)	missense_variant	Not In ClinVar	51.32 [30.46] mg/dL	1	3.98E-06	rs1188407566
2:21019753:G:A	LDL-C	APOB	UKBB	c.2969C>T (p.Ala990Val)	missense_variant	Not In ClinVar	65.4 [30.46] mg/dL	1	NA	NA
2:21019766:A:G	LDL-C	APOB	UKBB	c.2956T>C (p.Ser986Pro)	missense_variant	Not In ClinVar	32 [30.46] mg/dL	1	NA	NA
2:21019774:T:C	LDL-C	APOB	UKBB	c.2948A>G (p.Asn983Ser)	missense_variant	Not In ClinVar	88.16 [29.78] mg/dL	1	3.98E-06	rs1407756735
2:21019835:A:G	LDL-C	APOB	UKBB	c.2887T>C (p.Trp963Arg)	missense_variant	Not In ClinVar	48.26 [30.46] mg/dL	1	NA	rs1435043458
2:21022919:C:T	LDL-C	APOB	UKBB	c.2728G>A (p.Gly910Ser)	missense_variant	Not In ClinVar	30.06 [21.54] mg/dL	2	7.96E-06	rs747610107
2:21023026:A:G	LDL-C	APOB	UKBB	c.2621T>C (p.Val874Ala)	missense_variant	Not In ClinVar	20.92 [30.46] mg/dL	1	NA	NA
2:21023031:T:A	LDL-C	APOB	FOURIER	c.2616A>T (p.Glu872Asp)	missense_variant	Not In ClinVar	41.29 [27.42] mg/dL	1	3.98E-06	rs767525908
2:21023538:A:G	LDL-C	APOB	UKBB	c.2591T>C (p.Leu864Pro)	missense_variant	Not In ClinVar	49.6 [30.46] mg/dL	1	NA	NA
2:21023563:G:A	LDL-C	APOB	UKBB	c.2566C>T (p.Pro856Ser)	missense_variant	Not In ClinVar	31.96 [30.46] mg/dL	1	NA	NA
2:21023565:G:A	LDL-C	APOB	UKBB	c.2564C>T (p.Ala855Val)	missense_variant	Not In ClinVar	32.4 [30.46] mg/dL	1	NA	NA
2:21023595:T:C	LDL-C	APOB	UKBB	c.2534A>G (p.Gln845Arg)	missense_variant	Not In ClinVar	34.12 [30.46] mg/dL	1	NA	NA
2:21023622:A:G	LDL-C	APOB	UKBB	c.2507T>C (p.Phe836Ser)	missense_variant	Not In ClinVar	66.77 [30.46] mg/dL	1	NA	NA
2:21023634:A:G	LDL-C	APOB	UKBB	c.2495T>C (p.Met832Thr)	missense_variant	Not In ClinVar	34.25 [30.46] mg/dL	1	NA	NA
2:21024934:A:G	LDL-C	APOB	UKBB	c.2435T>C (p.Met812Thr)	missense_variant	Not In ClinVar	18.42 [30.46] mg/dL	1	NA	rs943834069
2:21024973:A:G	LDL-C	APOB	UKBB	c.2396T>C (p.Leu799Pro)	missense_variant	Not In ClinVar	49.27 [30.46] mg/dL	1	NA	NA
2:21024983:C:T	LDL-C	APOB	UKBB	c.2386G>A (p.Gly796Arg)	missense_variant	Not In ClinVar	36.48 [30.46] mg/dL	1	NA	NA
2:21024995:G:A	LDL-C	APOB	FOURIER	c.2374C>T (p.Leu792Phe)	missense_variant	Not In ClinVar	19.08 [27.14] mg/dL	1	NA	NA
2:21025023:C:G	LDL-C	APOB	UKBB	c.2346G>C (p.Glu782Asp)	missense_variant	Not In ClinVar	17.45 [15.24] mg/dL	4	2.78E-05	rs770250347
2:21025036:C:A	LDL-C	APOB	UKBB	c.2333G>T (p.Arg778Leu)	missense_variant	Not In ClinVar	27.84 [30.51] mg/dL	1	NA	NA
2:21025052:C:T	LDL-C	APOB	UKBB	c.2317G>A (p.Ala773Thr)	missense_variant	Not In ClinVar	79.72 [21.54] mg/dL	2	NA	NA
2:21025055:C:G	LDL-C	APOB	UKBB	c.2314G>C (p.Glu772Gln)	missense_variant	Not In ClinVar	43.23 [30.31] mg/dL	1	NA	NA
2:21025085:T:G	LDL-C	APOB	UKBB	c.2284A>C (p.Ile762Leu)	missense_variant	Not In ClinVar	78.99 [30.47] mg/dL	1	NA	NA
2:21025105:A:G	LDL-C	APOB	UKBB	c.2264T>C (p.Met755Thr)	missense_variant	Not In ClinVar	28.35 [30.46] mg/dL	1	NA	NA
2:21025121:T:C	LDL-C	APOB	UKBB	c.2248A>G (p.Met750Val)	missense_variant	Not In ClinVar	82.91 [30.47] mg/dL	1	4.00E-06	rs1335266600
2:21026901:A:G	LDL-C	APOB	UKBB	c.2131T>C (p.Phe711Leu)	missense_variant	Not In ClinVar	23.66 [21.37] mg/dL	2	3.98E-06	rs746180039
2:21026918:A:C	LDL-C	APOB	FOURIER	c.2114T>G (p.Phe705Cys)	missense_variant	Not In ClinVar	80.18 [27.23] mg/dL	1	3.98E-06	rs898106597
2:21026924:G:A	LDL-C	APOB	UKBB	c.2108C>T (p.Ala703Val)	missense_variant	Not In ClinVar	33.62 [30.46] mg/dL	1	NA	NA
2:21027979:A:C	LDL-C	APOB	UKBB	c.1916T>G (p.Leu639Arg)	missense_variant	Not In ClinVar	64.83 [30.46] mg/dL	1	NA	NA
2:21027992:G:A	LDL-C	APOB	UKBB	c.1903C>T (p.Arg635Trp)	missense_variant	Not In ClinVar	17.07 [30.46] mg/dL	1	2.39E-05	rs548108916
2:21028000:T:C	LDL-C	APOB	UKBB	c.1895A>G (p.Lys632Arg)	missense_variant	Not In ClinVar	19.93 [30.46] mg/dL	1	NA	NA
2:21028025:G:A	LDL-C	APOB	UKBB	c.1870C>T (p.Leu624Phe)	missense_variant	Not In ClinVar	21 [30.46] mg/dL	1	NA	rs1572795958
2:21028370:G:A	LDL-C	APOB	UKBB	c.1786C>T (p.His596Tyr)	missense_variant	Not In ClinVar	18.1 [30.46] mg/dL	1	NA	rs1461214675
2:21028453:C:T	LDL-C	APOB	UKBB	c.1703G>A (p.Ser568Asn)	missense_variant	Not In ClinVar	19.03 [30.46] mg/dL	1	NA	NA
2:21028455:C:G	LDL-C	APOB	UKBB	c.1701G>C (p.Arg567Ser)	missense_variant	Not In ClinVar	34.3 [21.5] mg/dL	2	NA	rs981207307
2:21028466:T:G	LDL-C	APOB	FOURIER	c.1690A>C (p.Met564Leu)	missense_variant	Not In ClinVar	24.05 [27.42] mg/dL	1	NA	NA
2:21028499:A:G	LDL-C	APOB	UKBB	c.1657T>C (p.Ser553Pro)	missense_variant	Not In ClinVar	18.6 [30.27] mg/dL	1	NA	NA
2:21029748:G:A	LDL-C	APOB	UKBB	c.1508C>T (p.Thr503Ile)	missense_variant	Not In ClinVar	30.09 [30.46] mg/dL	1	NA	NA
2:21032529:G:A	LDL-C	APOB	UKBB	c.1177C>T (p.His393Tyr)	missense_variant	Not In ClinVar	19.42 [30.46] mg/dL	1	NA	NA
2:21032540:T:C	LDL-C	APOB	UKBB	c.1166A>G (p.Gln389Arg)	missense_variant	Not In ClinVar	82.59 [30.46] mg/dL	1	NA	rs1135402763
2:21033416:G:A	LDL-C	APOB	UKBB	c.1007C>T (p.Thr336Ile)	missense_variant	Not In ClinVar	41.63 [30.47] mg/dL	1	NA	NA
2:21033422:T:G	LDL-C	APOB	UKBB	c.1001A>C (p.Lys334Thr)	missense_variant	Not In ClinVar	42.1 [30.47] mg/dL	1	3.98E-06	rs1373621190
2:21033458:G:T	LDL-C	APOB	UKBB	c.965C>A (p.Ala322Asp)	missense_variant	Not In ClinVar	24.56 [21.54] mg/dL	2	3.98E-06	rs750454285
2:21033518:C:G	LDL-C	APOB	UKBB	c.905G>C (p.Gly302Ala)	missense_variant	Not In ClinVar	27.16 [21.54] mg/dL	2	NA	NA
2:21035592:G:C	LDL-C	APOB	UKBB	c.810C>G (p.Phe270Leu)	missense_variant	Not In ClinVar	64.72 [23.56] mg/dL	2	NA	NA
2:21035643:C:A	LDL-C	APOB	UKBB	c.759G>T (p.Arg253Ser)	missense_variant	Not In ClinVar	36.38 [21.54] mg/dL	2	NA	NA
2:21035686:A:C	LDL-C	APOB	UKBB	c.716T>G (p.Ile239Ser)	missense_variant	Not In ClinVar	62.84 [30.46] mg/dL	1	NA	NA
2:21037101:A:G	LDL-C	APOB	UKBB	c.692T>C (p.Met231Thr)	missense_variant	Not In ClinVar	20.2 [29.93] mg/dL	1	NA	NA
2:21040991:T:G	LDL-C	APOB	UKBB	c.330A>C (p.Lys110Asn)	missense_variant	Not In ClinVar	50.45 [15.58] mg/dL	4	NA	NA
2:21041026:G:T	LDL-C	APOB	UKBB	c.295C>A (p.Leu99Met)	missense_variant	Not In ClinVar	60 [30.46] mg/dL	1	NA	NA
2:21041055:C:T	LDL-C	APOB	UKBB	c.266G>A (p.Ser89Asn)	missense_variant	Not In ClinVar	17.31 [12.43] mg/dL	6	3.99E-06	rs1226992086
2:21042393:C:A	LDL-C	APOB	UKBB	c.205G>T (p.Asp69Tyr)	missense_variant	Not In ClinVar	18.83 [30.47] mg/dL	1	NA	NA
2:21042402:C:G	LDL-C	APOB	UKBB	c.196G>C (p.Gly66Arg)	missense_variant	Not In ClinVar	57.69 [30.46] mg/dL	1	NA	NA
2:21042473:T:C	LDL-C	APOB	UKBB	c.125A>G (p.Asp42Gly)	missense_variant	Not In ClinVar	30.69 [30.47] mg/dL	1	NA	NA
2:21043539:A:C	LDL-C	APOB	UKBB	c.95T>G (p.Leu32Arg)	missense_variant	Not In ClinVar	43.28 [30.46] mg/dL	1	NA	rs1350695060
20:44406138:C:T	HbA1c	HNF4A	UKBB	c.196C>T (p.Arg66Trp)	missense_variant	Not In ClinVar	0.53 [0.49] (%)	1	NA	NA
20:44407388:C:G	HbA1c	HNF4A	UKBB	c.298C>G (p.Arg100Gly)	missense_variant	Not In ClinVar	1.62 [0.49] (%)	1	NA	NA
20:44407414:G:C	HbA1c	HNF4A	UKBB	c.324G>C (p.Lys108Asn)	missense_variant	Not In ClinVar	0.52 [0.49] (%)	1	NA	NA
20:44413711:G:A	HbA1c	HNF4A	UKBB	c.403G>A (p.Asp135Asn)	missense_variant	Not In ClinVar	0.31 [0.49] (%)	1	NA	NA
20:44413727:G:A	HbA1c	HNF4A	FOURIER	c.419G>A (p.Arg140Gln)	missense_variant	Not In ClinVar	0.62 [0.89] (%)	1	4.78E-05	rs764196059
20:44413739:A:G	HbA1c	HNF4A	UKBB	c.431A>G (p.Tyr144Cys)	missense_variant	Not In ClinVar	0.9 [0.49] (%)	1	NA	NA
20:44413769:C:T	HbA1c	HNF4A	UKBB	c.461C>T (p.Ala154Val)	missense_variant	Not In ClinVar	0.31 [0.34] (%)	2	1.20E-05	rs147342965
20:44414534:G:A	HbA1c	HNF4A	UKBB	c.520G>A (p.Gly174Ser)	missense_variant	Not In ClinVar	0.66 [0.16] (%)	10	7.95E-06	rs760038979
20:44414581:G:C	HbA1c	HNF4A	UKBB	c.567G>C (p.Glu189Asp)	missense_variant	Not In ClinVar	0.74 [0.49] (%)	1	NA	NA
20:44414617:G:A	HbA1c	HNF4A	UKBB	c.603G>A (p.Trp201Ter)	stop_gained	Not In ClinVar	0.53 [0.49] (%)	1	NA	NA
20:44414649:C:T	HbA1c	HNF4A	FOURIER	c.635C>T (p.Pro212Leu)	missense_variant	Not In ClinVar	0.48 [0.45] (%)	4	1.65E-04	rs201749293
20:44414660:C:A	HbA1c	HNF4A	UKBB	c.646C>A (p.Gln216Lys)	missense_variant	Not In ClinVar	0.37 [0.49] (%)	1	NA	NA
20:44419732:A:G	HbA1c	HNF4A	UKBB	c.748A>G (p.Ile250Val)	missense_variant	Not In ClinVar	0.7 [0.49] (%)	1	1.19E-05	rs773402510
20:44419741:C:T	HbA1c	HNF4A	UKBB	c.757C>T (p.Arg253Trp)	missense_variant	Not In ClinVar	0.75 [0.34] (%)	2	3.98E-06	rs376013528
20:44419764:G:C	HbA1c	HNF4A	UKBB	c.780G>C (p.Glu260Asp)	missense_variant	Not In ClinVar	0.34 [0.34] (%)	2	NA	rs1259110384
20:44419766:T:C	HbA1c	HNF4A	UKBB	c.782T>C (p.Met261Thr)	missense_variant	Not In ClinVar	0.34 [0.48] (%)	1	NA	NA
20:44424117:G:T	HbA1c	HNF4A	UKBB	c.992G>T (p.Arg331Leu)	missense_variant	Not In ClinVar	1.23 [0.29] (%)	3	NA	NA
20:44424222:T:C	HbA1c	HNF4A	UKBB	c.1097T>C (p.Ile366Thr)	missense_variant	Not In ClinVar	0.69 [0.34] (%)	2	3.99E-06	rs777332317
20:44424224:G:T	HbA1c	HNF4A	UKBB	c.1099G>T (p.Asp367Tyr)	missense_variant	Not In ClinVar	0.49 [0.49] (%)	1	NA	NA
20:44428401:G:A	HbA1c	HNF4A	UKBB	c.1196G>A (p.Gly399Glu)	missense_variant	Not In ClinVar	0.37 [0.49] (%)	1	3.98E-06	rs769972803
20:44428427:A:G	HbA1c	HNF4A	UKBB	c.1222A>G (p.Met408Val)	missense_variant	Not In ClinVar	1.13 [0.49] (%)	1	4.38E-05	rs530264224
20:44428431:C:A	HbA1c	HNF4A	UKBB	c.1226C>A (p.Pro409His)	missense_variant	Not In ClinVar	0.39 [0.28] (%)	3	3.98E-06	rs148745312
20:44428436:C:A	HbA1c	HNF4A	UKBB	c.1231C>A (p.His411Asn)	missense_variant	Not In ClinVar	0.43 [0.34] (%)	2	7.96E-06	rs762669064
20:44428440:T:C	HbA1c	HNF4A	UKBB	c.1235T>C (p.Leu412Pro)	missense_variant	Not In ClinVar	0.36 [0.49] (%)	1	NA	NA
20:44428457:T:C	HbA1c	HNF4A	UKBB	c.1252T>C (p.Cys418Arg)	missense_variant	Not In ClinVar	0.49 [0.49] (%)	1	NA	NA
20:44428479:G:A	HbA1c	HNF4A	UKBB	c.1274G>A (p.Gly425Glu)	missense_variant	Not In ClinVar	0.47 [0.28] (%)	3	2.40E-05	rs755961897
3:38550406:T:C	QTc	SCN5A	TOPMed	c.5963A>G (p.Gln1988Arg)	missense_variant	Not In ClinVar	24.15 [21.77] ms	1	NA	rs1052861074
3:38550622:A:G	QTc	SCN5A	TOPMed	c.5747T>C (p.Leu1916Pro)	missense_variant	Not In ClinVar	43.37 [22.2] ms	1	NA	rs765713843
3:38550671:C:T	QTc	SCN5A	UKBB	c.5698G>A (p.Glu1900Lys)	missense_variant	Not In ClinVar	24.84 [13.32] ms	3	2.01E-05	rs199473325
3:38550993:C:G	QTc	SCN5A	TOPMed	c.5376G>C (p.Met1792Ile)	missense_variant	Not In ClinVar	32.09 [21.86] ms	1	NA	NA
3:38551454:C:T	QTc	SCN5A	UKBB	c.4915G>A (p.Ala1639Thr)	missense_variant	Not In ClinVar	18.2 [23.07] ms	1	NA	rs1016091566
3:38554279:C:A	QTc	SCN5A	TOPMed	c.4810G>T (p.Gly1604Cys)	missense_variant	Not In ClinVar	29.59 [22.35] ms	1	8.13E-06	rs794728938
3:38554302:A:G	QTc	SCN5A	TOPMed	c.4787T>C (p.Val1596Ala)	missense_variant	Not In ClinVar	46.03 [22.25] ms	1	NA	rs775062862
3:38554303:C:A	QTc	SCN5A	TOPMed	c.4786G>T (p.Val1596Leu)	missense_variant	Not In ClinVar	18.01 [21.86] ms	1	NA	rs199473279
3:38554476:C:A	QTc	SCN5A	UKBB	c.4613G>T (p.Cys1538Phe)	missense_variant	Not In ClinVar	47.74 [23.08] ms	1	4.01E-06	rs770780069
3:38554491:A:G	QTc	SCN5A	UKBB	c.4598T>C (p.Ile1533Thr)	missense_variant	Not In ClinVar	26.86 [23.07] ms	1	NA	NA
3:38556540:C:A	QTc	SCN5A	UKBB	c.4335G>T (p.Met1445Ile)	missense_variant	Not In ClinVar	31.87 [16.31] ms	2	NA	NA
3:38560200:C:T	QTc	SCN5A	UKBB	c.4189G>A (p.Val1397Met)	missense_variant	Not In ClinVar	49.18 [23.06] ms	1	8.02E-06	rs1434495282
3:38560202:T:C	QTc	SCN5A	UKBB	c.4187A>G (p.Lys1396Arg)	missense_variant	Not In ClinVar	17.27 [23.06] ms	1	NA	NA
3:38560362:A:G	QTc	SCN5A	TOPMed	c.4027T>C (p.Phe1343Leu)	missense_variant	Not In ClinVar	50.73 [22.19] ms	1	NA	rs199473228
3:38560389:T:C	QTc	SCN5A	TOPMed	c.4000A>G (p.Met1334Val)	missense_variant	Not In ClinVar	14.91 [22.35] ms	1	NA	rs374268607
3:38562477:A:C	QTc	SCN5A	UKBB	c.3898T>G (p.Ser1300Ala)	missense_variant	Not In ClinVar	21.2 [23.07] ms	1	NA	NA
3:38566567:A:G	QTc	SCN5A	UKBB	c.3679T>C (p.Tyr1227His)	missense_variant	Not In ClinVar	21.25 [23.07] ms	1	4.01E-06	rs199473205
3:38575437:A:T	QTc	SCN5A	UKBB	c.3523T>A (p.Cys1175Ser)	missense_variant	Not In ClinVar	21.87 [23.07] ms	1	NA	rs1390530399
3:38575442:C:T	QTc	SCN5A	UKBB	c.3518G>A (p.Arg1173Gln)	missense_variant	Not In ClinVar	25.36 [16.31] ms	2	NA	rs772266572
3:38576711:A:T	QTc	SCN5A	UKBB	c.3458T>A (p.Ile1153Asn)	missense_variant	Not In ClinVar	44.84 [16.31] ms	2	8.39E-06	rs536585114
3:38579437:C:A	QTc	SCN5A	TOPMed	c.3284G>T (p.Ser1095Ile)	missense_variant	Not In ClinVar	14.32 [21.81] ms	1	NA	rs1254283773
3:38579455:G:T	QTc	SCN5A	UKBB	c.3266C>A (p.Pro1089Gln)	missense_variant	Not In ClinVar	23.78 [23.07] ms	1	4.07E-06	rs1805125
3:38580944:T:G	QTc	SCN5A	TOPMed	c.3215A>C (p.Glu1072Ala)	missense_variant	Not In ClinVar	14.29 [12.13] ms	4	NA	rs879180388
3:38580945:C:A	QTc	SCN5A	TOPMed	c.3214G>T (p.Glu1072Ter)	stop_gained	Not In ClinVar	14.29 [12.13] ms	4	NA	rs879114460
3:38581049:C:A	QTc	SCN5A	TOPMed	c.3110G>T (p.Gly1037Val)	missense_variant	Not In ClinVar	21.48 [21.91] ms	1	NA	rs201831535
3:38581209:G:C	QTc	SCN5A	TOPMed	c.2950C>G (p.Leu984Val)	missense_variant	Not In ClinVar	13.83 [15.78] ms	2	NA	rs1388344088
3:38581222:A:T	QTc	SCN5A	TOPMed	c.2937T>A (p.Asp979Glu)	missense_variant	Not In ClinVar	16.28 [22.16] ms	1	NA	rs1370048998
3:38581263:T:C	QTc	SCN5A	UKBB	c.2896A>G (p.Ile966Val)	missense_variant	Not In ClinVar	13.35 [23.08] ms	1	NA	NA
3:38581278:G:C	QTc	SCN5A	TOPMed	c.2881C>G (p.Leu961Val)	missense_variant	Not In ClinVar	13.88 [21.85] ms	1	NA	NA
3:38585882:A:G	QTc	SCN5A	TOPMed	c.2596T>C (p.Ser866Pro)	missense_variant	Not In ClinVar	34.79 [21.87] ms	1	3.98E-06	rs781480956
3:38585887:T:C	QTc	SCN5A	UKBB	c.2591A>G (p.Asn864Ser)	missense_variant	Not In ClinVar	12.19 [23.07] ms	1	NA	NA
3:38587491:T:C	QTc	SCN5A	UKBB	c.2345A>G (p.Asn782Ser)	missense_variant	Not In ClinVar	13.46 [16.31] ms	2	NA	NA
3:38587525:G:A	QTc	SCN5A	UKBB	c.2311C>T (p.Leu771Phe)	missense_variant	Not In ClinVar	31.84 [23.1] ms	1	NA	NA
3:38597847:A:G	QTc	SCN5A	UKBB	c.2144T>C (p.Met715Thr)	missense_variant	Not In ClinVar	28.72 [16.31] ms	2	4.01E-06	rs1246637863
3:38597883:C:T	QTc	SCN5A	UKBB	c.2108G>A (p.Trp703Ter)	stop_gained	Not In ClinVar	72.41 [23.06] ms	1	NA	NA
3:38597896:A:G	QTc	SCN5A	UKBB	c.2095T>C (p.Cys699Arg)	missense_variant	Not In ClinVar	21.95 [23.06] ms	1	NA	NA
3:38599046:G:A	QTc	SCN5A	UKBB	c.1895C>T (p.Thr632Met)	missense_variant	Not In ClinVar	18.94 [23.06] ms	1	1.23E-05	rs199473134
3:38604004:C:G	QTc	SCN5A	TOPMed	c.1598G>C (p.Arg533Pro)	missense_variant	Not In ClinVar	12.2 [21.86] ms	1	NA	rs146848219
3:38604745:T:A	QTc	SCN5A	TOPMed	c.1502A>T (p.Asp501Val)	missense_variant	Not In ClinVar	12.89 [21.86] ms	1	NA	rs199473117
3:38606139:A:T	QTc	SCN5A	UKBB	c.1150T>A (p.Ser384Thr)	missense_variant	Not In ClinVar	28.06 [23.07] ms	1	4.02E-06	rs747551321
3:38609742:C:T	QTc	SCN5A	UKBB	c.926G>A (p.Ser309Asn)	missense_variant	Not In ClinVar	16.48 [23.06] ms	1	4.03E-06	rs780325353
3:38609764:C:T	QTc	SCN5A	TOPMed	c.904G>A (p.Glu302Lys)	missense_variant	Not In ClinVar	18.53 [21.85] ms	1	NA	rs1060501136
3:38609814:G:A	QTc	SCN5A	UKBB	c.854C>T (p.Thr285Ile)	missense_variant	Not In ClinVar	14.65 [23.07] ms	1	NA	NA
3:38609835:T:C	QTc	SCN5A	TOPMed	c.833A>G (p.His278Arg)	missense_variant	Not In ClinVar	20.12 [21.91] ms	1	NA	NA
3:38609917:C:T	QTc	SCN5A	TOPMed	c.751G>A (p.Ala251Thr)	missense_variant	Not In ClinVar	17.49 [21.88] ms	1	NA	rs1274755542
3:38613775:A:G	QTc	SCN5A	UKBB	c.671T>C (p.Leu224Pro)	missense_variant	Not In ClinVar	17.56 [23.09] ms	1	NA	NA
3:38620937:G:C	QTc	SCN5A	UKBB	c.517C>G (p.Leu173Val)	missense_variant	Not In ClinVar	35.55 [23.07] ms	1	NA	rs1257767162
3:38622408:C:A	QTc	SCN5A	UKBB	c.474G>T (p.Lys158Asn)	missense_variant	Not In ClinVar	38.47 [23.07] ms	1	NA	NA
3:38622419:G:T	QTc	SCN5A	UKBB	c.463C>A (p.Pro155Thr)	missense_variant	Not In ClinVar	17.63 [23.07] ms	1	NA	NA
3:38622428:C:T	QTc	SCN5A	UKBB	c.454G>A (p.Asp152Asn)	missense_variant	Not In ClinVar	49.09 [22.97] ms	1	1.22E-05	rs778337208
3:38622471:G:C	QTc	SCN5A	TOPMed	c.411C>G (p.Ile137Met)	missense_variant	Not In ClinVar	20.93 [21.88] ms	1	NA	rs1477081891
7:150946932:G:A	QTc	KCNH2	TOPMed	c.3275C>T (p.Ser1092Phe)	missense_variant	Not In ClinVar	29.73 [22.32] ms	1	4.10E-06	rs147510453
7:150947032:C:A	QTc	KCNH2	UKBB	c.3175G>T (p.Asp1059Tyr)	missense_variant	Not In ClinVar	21.88 [23.06] ms	1	NA	NA
7:150947048:C:A	QTc	KCNH2	UKBB	c.3159G>T (p.Glu1053Asp)	missense_variant	Not In ClinVar	27.55 [23.06] ms	1	NA	NA
7:150947053:G:T	QTc	KCNH2	UKBB	c.3154C>A (p.Leu1052Met)	missense_variant	Not In ClinVar	16.99 [23.07] ms	1	NA	NA
7:150947352:T:A	QTc	KCNH2	UKBB	c.3128A>T (p.Asp1043Val)	missense_variant	Not In ClinVar	13.63 [23.07] ms	1	NA	rs962739782
7:150947392:G:T	QTc	KCNH2	UKBB	c.3088C>A (p.Pro1030Thr)	missense_variant	Not In ClinVar	25.52 [23.08] ms	1	NA	NA
7:150947716:G:C	QTc	KCNH2	UKBB	c.2855C>G (p.Pro952Arg)	missense_variant	Not In ClinVar	20.11 [23.09] ms	1	NA	rs765920319
7:150947747:C:T	QTc	KCNH2	UKBB	c.2824G>A (p.Glu942Lys)	missense_variant	Not In ClinVar	15.05 [23.09] ms	1	NA	NA
7:150947827:G:A	QTc	KCNH2	TOPMed	c.2744C>T (p.Ala915Val)	missense_variant	Not In ClinVar	38.48 [22.22] ms	1	NA	rs199473437
7:150947831:C:G	QTc	KCNH2	TOPMed	c.2740G>C (p.Gly914Arg)	missense_variant	Not In ClinVar	26.15 [22.09] ms	1	NA	NA
7:150948488:C:T	QTc	KCNH2	UKBB	c.2648G>A (p.Arg883Gln)	missense_variant	Not In ClinVar	19.68 [16.31] ms	2	2.40E-05	rs748821862
7:150948525:A:C	QTc	KCNH2	TOPMed	c.2611T>G (p.Ser871Ala)	missense_variant	Not In ClinVar	23.79 [22.34] ms	1	NA	rs986136917
7:150948866:T:A	QTc	KCNH2	UKBB	c.2582A>T (p.Asn861Ile)	missense_variant	Not In ClinVar	46.36 [16.31] ms	2	NA	rs121912513
7:150948966:A:T	QTc	KCNH2	UKBB	c.2482T>A (p.Cys828Ser)	missense_variant	Not In ClinVar	47.5 [23.06] ms	1	NA	NA
7:150948991:G:T	QTc	KCNH2	TOPMed	c.2457C>A (p.Asn819Lys)	missense_variant	Not In ClinVar	36.85 [21.87] ms	1	3.98E-06	rs768725008
7:150950255:G:A	QTc	KCNH2	UKBB	c.2311C>T (p.His771Tyr)	missense_variant	Not In ClinVar	21.17 [23.07] ms	1	NA	NA
7:150950282:G:A	QTc	KCNH2	UKBB	c.2284C>T (p.His762Tyr)	missense_variant	Not In ClinVar	27.08 [16.31] ms	2	NA	NA
7:150950956:C:T	QTc	KCNH2	UKBB	c.2110G>A (p.Ala704Thr)	missense_variant	Not In ClinVar	28.26 [23.06] ms	1	3.98E-06	rs773524985
7:150951007:G:A	QTc	KCNH2	TOPMed	c.2059C>T (p.His687Tyr)	missense_variant	Not In ClinVar	15.6 [21.85] ms	1	NA	rs199472982
7:150951660:T:G	QTc	KCNH2	TOPMed	c.1733A>C (p.His578Pro)	missense_variant	Not In ClinVar	12.84 [21.87] ms	1	NA	rs794728376
7:150952477:A:G	QTc	KCNH2	TOPMed	c.1505T>C (p.Met502Thr)	missense_variant	Not In ClinVar	17.23 [21.87] ms	1	NA	rs867220128
7:150952519:C:T	QTc	KCNH2	TOPMed	c.1463G>A (p.Arg488His)	missense_variant	Not In ClinVar	31.27 [13.18] ms	3	1.19E-05	rs546266276
7:150952607:C:T	QTc	KCNH2	UKBB	c.1375G>A (p.Val459Met)	missense_variant	Not In ClinVar	16.57 [23.07] ms	1	NA	NA
7:150952669:T:C	QTc	KCNH2	TOPMed	c.1313A>G (p.Glu438Gly)	missense_variant	Not In ClinVar	16.08 [21.79] ms	1	NA	rs1031735029
7:150952793:G:T	QTc	KCNH2	UKBB	c.1189C>A (p.Arg397Ser)	missense_variant	Not In ClinVar	28.81 [23.06] ms	1	NA	NA
7:150957500:C:T	QTc	KCNH2	UKBB	c.919G>A (p.Ala307Thr)	missense_variant	Not In ClinVar	17.89 [23.08] ms	1	NA	NA
7:150958100:C:T	QTc	KCNH2	TOPMed	c.875G>A (p.Arg292His)	missense_variant	Not In ClinVar	27.96 [22.35] ms	1	NA	rs1355952300
7:150958169:C:T	QTc	KCNH2	UKBB	c.806G>A (p.Arg269Gln)	missense_variant	Not In ClinVar	14.98 [23.07] ms	1	NA	NA
7:150958221:G:A	QTc	KCNH2	TOPMed	c.754C>T (p.Arg252Trp)	missense_variant	Not In ClinVar	51.3 [13.23] ms	3	NA	rs199472874
7:150958229:G:A	QTc	KCNH2	TOPMed	c.746C>T (p.Pro249Leu)	missense_variant	Not In ClinVar	42.53 [22.26] ms	1	NA	NA
7:150958238:C:T	QTc	KCNH2	UKBB	c.737G>A (p.Gly246Asp)	missense_variant	Not In ClinVar	14.37 [23.06] ms	1	NA	NA
7:150958312:G:T	QTc	KCNH2	TOPMed	c.663C>A (p.His221Gln)	missense_variant	Not In ClinVar	16.96 [22.3] ms	1	NA	rs752896394
7:150958315:G:C	QTc	KCNH2	UKBB	c.660C>G (p.Asn220Lys)	missense_variant	Not In ClinVar	40.49 [23.11] ms	1	NA	NA
7:150958383:C:G	QTc	KCNH2	TOPMed	c.592G>C (p.Val198Leu)	missense_variant	Not In ClinVar	12.27 [21.88] ms	1	1.22E-05	rs768347062
7:150958399:C:CCCCGGGGCG	QTc	KCNH2	TOPMed	c.567_575dup (p.Pro191_Ala193dup)	inframe_insertion	Not In ClinVar	13.58 [15.46] ms	2	NA	rs1370496092
7:150958486:G:C	QTc	KCNH2	UKBB	c.489C>G (p.Phe163Leu)	missense_variant	Not In ClinVar	16.15 [23.07] ms	1	NA	rs1307704357
7:150959674:T:G	QTc	KCNH2	UKBB	c.370A>C (p.Met124Leu)	missense_variant	Not In ClinVar	21 [23.07] ms	1	NA	NA
7:150974783:C:T	QTc	KCNH2	TOPMed	c.235G>A (p.Ala79Thr)	missense_variant	Not In ClinVar	27.63 [21.87] ms	1	4.37E-06	rs794728494
7:150974783:C:T	QTc	KCNH2	UKBB	c.235G>A (p.Ala79Thr)	missense_variant	Not In ClinVar	16.73 [23.07] ms	1	4.37E-06	rs794728494
7:150974924:C:G	QTc	KCNH2	UKBB	c.94G>C (p.Ala32Pro)	missense_variant	Not In ClinVar	21.18 [23.07] ms	1	NA	NA
7:150974930:T:G	QTc	KCNH2	UKBB	c.88A>C (p.Ile30Leu)	missense_variant	Not In ClinVar	18.19 [23.08] ms	1	NA	NA
7:44145502:G:T	HbA1c	GCK	UKBB	c.1248C>A (p.His416Gln)	missense_variant	Not In ClinVar	0.59 [0.34] (%)	2	NA	NA
7:44145522:C:G	HbA1c	GCK	UKBB	c.1228G>C (p.Gly410Arg)	missense_variant	Not In ClinVar	1.18 [0.49] (%)	1	NA	NA
7:44145542:C:G	HbA1c	GCK	UKBB	c.1208G>C (p.Arg403Pro)	missense_variant	Not In ClinVar	0.33 [0.24] (%)	4	NA	NA
7:44145560:C:T	HbA1c	GCK	UKBB	c.1190G>A (p.Arg397His)	missense_variant	Not In ClinVar	1.38 [0.49] (%)	1	NA	NA
7:44145569:C:T	HbA1c	GCK	FOURIER	c.1181G>A (p.Arg394His)	missense_variant	Not In ClinVar	0.99 [0.89] (%)	1	NA	rs1235227560
7:44145606:A:C	HbA1c	GCK	FOURIER	c.1144T>G (p.Cys382Gly)	missense_variant	Not In ClinVar	0.87 [0.89] (%)	1	NA	NA
7:44145725:G:C	HbA1c	GCK	FOURIER	c.1025C>G (p.Thr342Arg)	missense_variant	Not In ClinVar	0.59 [0.89] (%)	1	2.88E-05	rs749208290
7:44146557:G:T	HbA1c	GCK	UKBB	c.925C>A (p.Leu309Ile)	missense_variant	Not In ClinVar	1.21 [0.37] (%)	2	NA	NA
7:44146558:C:A	HbA1c	GCK	UKBB	c.924G>T (p.Arg308Ser)	missense_variant	Not In ClinVar	0.62 [0.49] (%)	1	NA	NA
7:44146563:G:A	HbA1c	GCK	UKBB	c.919C>T (p.Leu307Phe)	missense_variant	Not In ClinVar	0.79 [0.49] (%)	1	NA	NA
7:44146572:G:A	HbA1c	GCK	UKBB	c.910C>T (p.Leu304Phe)	missense_variant	Not In ClinVar	3.76 [0.49] (%)	1	NA	NA
7:44146604:A:C	HbA1c	GCK	UKBB	c.878T>G (p.Ile293Arg)	missense_variant	Not In ClinVar	0.97 [0.49] (%)	1	NA	NA
7:44147679:G:T	HbA1c	GCK	FOURIER	c.834C>A (p.Asp278Glu)	missense_variant	Not In ClinVar	0.67 [0.89] (%)	1	NA	NA
7:44147798:G:C	HbA1c	GCK	FOURIER	c.715C>G (p.Gln239Glu)	missense_variant	Not In ClinVar	1.04 [0.89] (%)	1	NA	NA
7:44147800:A:G	HbA1c	GCK	UKBB	c.713T>C (p.Met238Thr)	missense_variant	Not In ClinVar	0.55 [0.49] (%)	1	NA	NA
7:44147809:A:G	HbA1c	GCK	FOURIER	c.704T>C (p.Met235Thr)	missense_variant	Not In ClinVar	1.26 [0.89] (%)	1	NA	rs193922323
7:44147810:T:A	HbA1c	GCK	UKBB	c.703A>T (p.Met235Leu)	missense_variant	Not In ClinVar	0.98 [0.49] (%)	1	NA	NA
7:44147816:A:G	HbA1c	GCK	UKBB	c.697T>C (p.Cys233Arg)	missense_variant	Not In ClinVar	1.37 [0.49] (%)	1	NA	NA
7:44149781:A:T	HbA1c	GCK	UKBB	c.658T>A (p.Cys220Ser)	missense_variant	Not In ClinVar	0.89 [0.49] (%)	1	NA	NA
7:44149785:A:T	HbA1c	GCK	UKBB	c.654T>A (p.His218Gln)	missense_variant	Not In ClinVar	0.82 [0.34] (%)	2	NA	NA
7:44149797:G:GT	HbA1c	GCK	UKBB	c.641dup (p.Tyr214Ter)	"stop_gained,frameshift_variant"	Not In ClinVar	1.66 [0.49] (%)	1	NA	NA
7:44149817:C:A	HbA1c	GCK	UKBB	c.622G>T (p.Ala208Ser)	missense_variant	Not In ClinVar	1.51 [0.49] (%)	1	NA	NA
7:44149832:C:T	HbA1c	GCK	UKBB	c.607G>A (p.Val203Met)	missense_variant	Not In ClinVar	1.32 [0.49] (%)	1	NA	NA
7:44149981:G:C	HbA1c	GCK	UKBB	c.567C>G (p.Ile189Met)	missense_variant	Not In ClinVar	1.33 [0.49] (%)	1	NA	NA
7:44150961:C:A	HbA1c	GCK	UKBB	c.478G>T (p.Asp160Tyr)	missense_variant	Not In ClinVar	0.82 [0.49] (%)	1	NA	NA
7:44150978:A:G	HbA1c	GCK	UKBB	c.461T>C (p.Val154Ala)	missense_variant	Not In ClinVar	0.99 [0.34] (%)	2	NA	NA
7:44151010:C:A	HbA1c	GCK	UKBB	c.429G>T (p.Lys143Asn)	missense_variant	Not In ClinVar	0.47 [0.49] (%)	1	NA	NA
7:44151033:T:C	HbA1c	GCK	UKBB	c.406A>G (p.Lys136Glu)	missense_variant	Not In ClinVar	0.71 [0.49] (%)	1	NA	rs1330663908
7:44151048:A:G	HbA1c	GCK	UKBB	c.391T>C (p.Ser131Pro)	missense_variant	Not In ClinVar	1.17 [0.49] (%)	1	NA	rs104894010
7:44152275:TCAGCAGTG:T	HbA1c	GCK	UKBB	c.351_358del (p.Thr118AspfsTer8)	frameshift_variant	Not In ClinVar	0.99 [0.49] (%)	1	NA	NA
7:44152285:C:G	HbA1c	GCK	UKBB	c.349G>C (p.Gly117Arg)	missense_variant	Not In ClinVar	1.04 [0.49] (%)	1	NA	NA
7:44152318:G:A	HbA1c	GCK	UKBB	c.316C>T (p.Gln106Ter)	stop_gained	Not In ClinVar	1.07 [0.34] (%)	2	NA	NA
7:44153306:C:T	HbA1c	GCK	UKBB	c.203G>A (p.Gly68Asp)	missense_variant	Not In ClinVar	0.32 [0.1] (%)	25	1.99E-05	rs373418736
7:44153339:A:T	HbA1c	GCK	UKBB	c.170T>A (p.Met57Lys)	missense_variant	Not In ClinVar	1.36 [0.49] (%)	1	NA	NA
7:44153367:C:T	HbA1c	GCK	FOURIER	c.142G>A (p.Glu48Lys)	missense_variant	Not In ClinVar	1.35 [0.63] (%)	2	2.78E-05	rs759514960
7:44153408:A:G	HbA1c	GCK	UKBB	c.101T>C (p.Met34Thr)	missense_variant	Not In ClinVar	0.42 [0.49] (%)	1	NA	NA
7:44153438:T:G	HbA1c	GCK	UKBB	c.71A>C (p.Gln24Pro)	missense_variant	Not In ClinVar	0.38 [0.49] (%)	1	NA	NA