Lean body mass GWAS

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Publications

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Zillikens MC, et al.
Nat Commun. 2017 Jul 19;8(1):80. doi: 10.1038/s41467-017-00031-7.
PMID:28724990

Phenotypes

  • total body lean mass
  • appendicular lean mass

Subjects

Subjects Cohort Ancestry
2,418 Age, Gene/Environment Susceptibility Reykjavik Study (AGES‚ÄźReykjavik) European
842 Amish Family Osteoporosis Study (Amish) European
3,190 Cardiovascular Health Study (CHS) Mixed
5,362 Cohorte Lausannoise (CoLaus) European
2,991 University Hospital Bone Mineral Study and Study on genetics of bone mass (deCODE) European
1,691 The European Prospective Investigation of Cancer Obesity Study (EPIC Obesity Study) European
2,097 Erasmus Rucphen Family Study (ERF) European
1,278 The Fenland Study (Fenland) European
2,956 The Framingham Heart Study (FRAM) European
940 Gothenburg Osteoporosis and Obesity Determinants Study (GOOD) European
1,654 Health Aging and Body Composition Study (HABC) European
1,467 Indiana Sisters Osteoporosis Study (Indiana) European
1,555 Cooperative Health Research in the Region of Augsburg (KORA F3) European
1,794 Cooperative Health Research in the Region of Augsburg (KORA F4) European
817 The London Life Sciences Prospective Population Study (Lolipop I) European
625 The London Life Sciences Prospective Population Study (Lolipop II) European
2,435 The Rotterdam Study I (RS I) European
816 The Rotterdam Study II (RS II) European
1,685 Twins UK (TUK I) European
1,697 Twins UK (TUK II) European

Project

Genetic Factors for Osteoporosis (GEFOS) Consortium Learn more >

 

Experiment summary

This study analyzed genetic associations for total body lean mass and appendicular (arms and legs) lean body mass, as measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis.

contributing community
msk, mskkp, bone
Dataset ID
GWAS_GEFOS-LeanBodyMass_eu